DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and GRID2IP

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_001138590.1 Gene:GRID2IP / 392862 HGNCID:18464 Length:1211 Species:Homo sapiens


Alignment Length:798 Identity:154/798 - (19%)
Similarity:246/798 - (30%) Gaps:301/798 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 HAADFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCV--- 177
            ||.. |.|||::.:::|::..|||.::::.:     :..||.:             ..||.|   
Human    39 HAGG-LRPGDQILEVEGLAVGGLSRERLVRL-----ARRCPRV-------------PPSLGVLPA 84

  Fly   178 --------TSKLAQITVERESGC-LGLTLRGGADYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDN 233
                    :...|..||.|...| .||.|  |.:...:....||.. |::..|.|..:...:||.
Human    85 PDGGPGPGSGPAAPTTVLRAPRCGRGLAL--GRELLRLAGRKRPDA-VHRERRRKAQEFSRKVDE 146

  Fly   234 VSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNY 298
            :  :|......:|:.                 .::.|          ...|:.::|    ::...
Human   147 I--LGDQPTAKEQVF-----------------AALKQ----------FAAEQRVDD----LVWTL 178

  Fly   299 TAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPD 363
            |.|:|                               .:.||.|        :|:..|    |.|.
Human   179 TLALP-------------------------------REACGPL--------LDNLRI----FIPK 200

  Fly   364 EVMTILDTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLP 428
            :.....|....:|     ::.....|||..   |:.:...|..|.|.      :|...:.::|.|
Human   201 KHRARFDEVVSQG-----LLGKLCRARRAQ---GAQRLRRSRSEERP------ERLLVSTRASAP 251

  Fly   429 LENPACGTPGS----TGGSMGTGGIH-------GSSSLGMGLGLCRAESFPVLLDCSHGAGIILS 482
            ...|....|..    .||..|.||..       |:.|.|..|                       
Human   252 PRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTL----------------------- 293

  Fly   483 ETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAIN----------KMYSL--DAAAMRQL- 534
                  .|.|.|.|..::|.|.|| :..:::||||:.:|          |:.|:  .:.||..| 
Human   294 ------RGHGPVWIESVLPGSPAD-NAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLV 351

  Fly   535 LEGG-----------SSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSV 588
            :|.|           .|.|.:|..|...|: .||   :|.::......||.:|            
Human   352 VEEGLVPFASDSDSLDSPNPSSALTSLQWV-AEI---LPSSIRVQGRTFSQQL------------ 400

  Fly   589 SGSSHGGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALL----------------- 636
               .|         :.:|..|.|..|:.:...       ||.|:|.|:                 
Human   401 ---EH---------LLTPPERYGVCRALESFF-------QHRNIDTLIVDVYPVLDTPAKQVLWQ 446

  Fly   637 --------KEEGRSQNPSHSSSDFTTLT--------IKRIVLPDFLPMSS-PIYSNCPAS----G 680
                    :|:...|........:|.:|        ::....|:..|.|| ...|.|..|    |
Human   447 FIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPELDLESEPTPEPQPRSSLRASSMCRRSLRSQG 511

  Fly   681 INLGMGMGVSTSTDHDLYSSAYVTAGKYA-DCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSG 744
            :..|:..|.|...:..|   ..:...:.| |..|| ..||.      |.|..|....::.|..|.
Human   512 LEAGLSCGPSECPEMPL---PLIPGERQAGDGTSL-PETPN------PKMMSAVYAELESRLNSS 566

  Fly   745 SNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEED----EQEQMYP---------------- 789
            ..|        ..|..|:|..:||......|..|....    ..|::.|                
Human   567 FKG--------KMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPS 623

  Fly   790 GYELNRYASVDCTALPPP 807
            ..|.:.|||:|.:..|.|
Human   624 SSESHPYASLDSSRAPSP 641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 10/30 (33%)
PDZ_signaling 183..254 CDD:238492 17/71 (24%)
PDZ_signaling 278..375 CDD:238492 13/96 (14%)
PDZ 496..>521 CDD:294084 9/24 (38%)
PDZ_signaling 571..658 CDD:238492 17/119 (14%)
PDZ_signaling 832..913 CDD:238492
PDZ_signaling 973..1055 CDD:238492
GRID2IPNP_001138590.1 PDZ_signaling 14..74 CDD:238492 11/40 (28%)
HN_L-delphilin-R1_like 133..212 CDD:259820 20/154 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..269 9/48 (19%)
PDZ_signaling 278..353 CDD:238492 22/104 (21%)
HN_L-delphilin-R2_like 389..468 CDD:259821 15/109 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..502 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..549 7/33 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..600 8/39 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..672 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..783
FH2 820..1188 CDD:280362
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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