DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and Ptpmeg

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster

Alignment Length:	1011	Identity:	196/1011 - (19%)
Similarity:	325/1011 - (32%)	Gaps:	345/1011 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 PGDRLHQIDGISTIGLSNQKVMNMLCAGGS---DACPAI-------------VEIEYS------- 164
            |||.:..:|.        ||.....|:..|   ||.|.:             ::.|::
  Fly    83 PGDVVRWVDA--------QKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQ 139

  Fly   165 ------LPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGADYPLIVTHVRPHGPVY------ 217
                  |.:...|.|:.|:   ||..||:.|.|          |:     :...|.|.|
  Fly   140 IKRNILLGKLPCSSNTQCL---LASYTVQSELG----------DF-----NALEHQPGYLSGMQL 186

  Fly   218 ----------KTGRIK-------PGDR----LLRVDNVSLIGKTLAEAQ----QIIKCGGHVSGY 257
                      |.|.:.       |.|.    |.....:.|.|..|..|.    :.::.|  ||..
  Fly   187 LCDQTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLG--VSAV 249

  Fly   258 TNLTIEYDVSV-------VQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSG 315
            ..|..::.:.|       :..|.|......|::.|..::       ||...:   |.|.|:....
  Fly   250 GLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSE-------NYDTLL---GFGMSSHKHA 304

  Fly   316 EKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQM 380
            :.:.:|.                                :||.:|                   .
  Fly   305 KALWKSC--------------------------------VEHHSF-------------------F 318

  Fly   381 QIMPAHALARRGHTTLGSPKYSFSTLE---SRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGG 442
            ::...|.|:|..:.:|||..|.....|   .::|...||..:.|.|       :|:....|:.||
  Fly   319 RLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVR-------SPSKRLLGAAGG 376

  Fly   443 SMGTGGIHGSSSLGMGLGLCRAESF----PVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDS 503
             :||.|..|.:.:....|...|.|.    |.      |||.||:.|.:.......|...:  .||
  Fly   377 -VGTSGSSGGTPMQQHSGSESANSHNNGKPA------GAGTILTITKTSRPHDNKVTSKE--ADS 432

  Fly   504 VADRSGCIQAGDRIVAINKMYSLDAAAMRQLLEGGSSRNGA------SNGTPANWLELEIEFDMP 562
            :..::...|:.:..:      .||...:.|......|.:.:      |:|..:..|   :...:.
  Fly   433 MPRKAWEQQSDEYDI------QLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPIL---LPTTIA 488

  Fly   563 DAV---VPASG--VFSVKLLRAGKCGLGLSVSGSSHGGL--VISDVKMGSPAHR-SGSLRSGDIL 619
            |||   .|.||  :.:::|....:...|.:|.|.....|  .:|.|...:||.| :..:..||.:
  Fly   489 DAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEV 553

  Fly   620 LAV---DQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPAS-- 679
            |.:   |.|.::|..|.|::::      ..|.:|....||::.......|....|:|...|.|
  Fly   554 LMINGRDVHGLRHEQVVAMIRD------CRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDE 612

  Fly   680 -GINLGMGMGVSTSTDHDLYSSAYVTAG-----------KYADCVSLKSRTP---QPDYFRVPSM 729
             |.:..:..|.:..|...|..|..:.:|           |..|....::|.|   ..:.:|..|.
  Fly   613 IGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISP 677

  Fly   730 DDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRS--YVAPPNTQSLTTELPEEEDEQEQMYPGYE 792
            .|.:..|:                     |||.:  |:   |...:..|:           ||..
  Fly   678 YDCTRVSL---------------------VNSLTGDYI---NANYVNMEI-----------PGGA 707

  Fly   793 LNRYASVDCTALPPPMENKVYGSAASSSS------KSSGSSLHQIIFTV---------------- 835
            :|||.:..             |..||:::      :...|.|..::.||
  Fly   708 VNRYIATQ-------------GPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTG 759

  Fly   836 -RLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGD-QLLAIDEHSVQGMP----- 893
             .|:...|.....|:...|.|.|......|   :..|:.|.|:.. |.||..:|.|...|
  Fly   760 EELQLAEGFSVRCLSEKPDETGSFVFREFV---LKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLE 821

  Fly   894 ------LSHATSLLQNLGDLVDLKILRSHDL-----ANGSHLPQTQAIYAKVQRRPRSPSANTEA 947
                  .:...:|||.:.:  .||.:|..|.     .||..:            |.|..:|:..|
  Fly   822 FTERVRAARNRTLLQEIEE--SLKQVRLMDADADADENGGLM------------RERKCAASNGA 872

  Fly   948 SKESGS----------GNANGGGAVNGNSGSGKPRV 973
            :.|..:          ..||....|:.::|.|:..|
  Fly   873 TPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGV 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	6/23 (26%)
		PDZ_signaling	183..254	CDD:238492	18/101 (18%)
		PDZ_signaling	278..375	CDD:238492	11/96 (11%)
		PDZ	496..>521	CDD:294084	3/24 (13%)
		PDZ_signaling	571..658	CDD:238492	22/92 (24%)
		PDZ_signaling	832..913	CDD:238492	23/109 (21%)
		PDZ_signaling	973..1055	CDD:238492	1/1 (100%)
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	33/174 (19%)
		FERM_N	38..102	CDD:286467	7/26 (27%)
		FERM_M	125..232	CDD:278785	22/124 (18%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	22/156 (14%)
		FA	333..369	CDD:285894	11/42 (26%)
		PDZ_signaling	502..589	CDD:238492	22/92 (24%)
		Y_phosphatase	666..955	CDD:278528	58/308 (19%)
		PTPc	668..955	CDD:238006	58/306 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900