DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Erbin

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_017446668.2 Gene:Erbin / 365661 RGDID:1562952 Length:1451 Species:Rattus norvegicus


Alignment Length:1186 Identity:225/1186 - (18%)
Similarity:365/1186 - (30%) Gaps:406/1186 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LKQDQQQQQQQQQESHNNSFNGHHHPPTDTALAPMLSVDRAMSPAQSEDSGLAPERGTTYATITL 85
            |||.:.||...:.:....|.:.......|.....|.||.:...|....::|.:|        :|.
  Rat   518 LKQHEDQQVVNKDKGVKPSESITTKSKLDEREKYMNSVPKTSEPEAETNAGNSP--------VTT 574

  Fly    86 PR----NALHLA---ITFAERNDLS----------YPPVV-GSLNPVGHAADFLAPGDRLHQIDG 132
            .|    |..||.   ..|.|..:||          .||:: .|:|.....|......|.....|.
  Rat   575 NRKSSGNMKHLVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDAKDTDS 639

  Fly   133 ISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTL 197
            :|.....|....|..|:.     |:.:....||...:....:||..:|  ||             
  Rat   640 LSDEVTHNSNQNNSNCSS-----PSRMSDSVSLNTDSSQDTALCSPAK--QI------------- 684

  Fly   198 RGGADYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTI 262
                             |:....:|:..|     :|.:                           
  Rat   685 -----------------PIDSNSKIRQED-----ENFN--------------------------- 700

  Fly   263 EYDVSVVQS-VEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFI 326
                |::|: |..:..|   |.:..:|||....|..|..                .|||.. |.|
  Rat   701 ----SLLQNGVNLNNSP---EEKFKINDKKDFKLPEYDL----------------NIEEQL-VLI 741

  Fly   327 ASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARR 391
            ..             .|..:..|.|...::|...:.::::|       ....|.:||..   ::.
  Rat   742 EK-------------DVDSKATSEDSHQLDHINMNLNKLVT-------NNIFQPEIMER---SKM 783

  Fly   392 GHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHGSSSLG 456
            ....||:   .|.::.|:..:.......:|....|:   |...|....|..|.|......:|...
  Rat   784 QDIVLGT---GFLSIHSKSEAEHIENGNKFLNSESI---NKVNGLSEDTAQSPGRIEPQNTSPAD 842

  Fly   457 MGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGC-IQAGDRIVAI 520
            :|:.....:..|   ..|..||.::......:..:|.:.|..|:.|......|. ::....:...
  Rat   843 VGISKSTEDLSP---QRSGPAGSVVKSHSITNMETGGLKIYDILSDDGPQPPGATVKVASTMDGK 904

  Fly   521 NKMYSLDAAAM----RQLLEGGSSRNGASNGTPANWLELEIEFDM------PD----AVVPASGV 571
            |.:.|..|..:    .|:....||.:...:||.|     ..:||.      ||    ::||  |.
  Rat   905 NIVRSKSATLLYDQPLQVFTASSSSSELLSGTKA-----VFKFDSNHNPEDPDIIRASIVP--GP 962

  Fly   572 FSVKLLRAGKCGLGLSVSGSSHGGLVISDVKMGSPAHR---SGSLRSGDILLAVDQHPVQHFNVD 633
            .|:..|                         .|.|.:.   |||....|.|    .||.|:..:|
  Rat   963 QSIPQL-------------------------YGPPQYNVQYSGSAAMKDTL----WHPKQNPQID 998

  Fly   634 AL------LKEEGRSQNPSH--------------------------------------SSSDFTT 654
            .:      |.....::|.|:                                      |.:|...
  Rat   999 PVSFPPQRLPRSESAENHSYTKHSANMNFSNHNNVRANTAYHLHQRLAPTRHGEMWAVSPNDRLV 1063

  Fly   655 LTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTP 719
            ..:.|..:.....:||       .:.:||| ..|.:..|:.|..|        |.:..|: .|||
  Rat  1064 PAVSRTTVQRQSSVSS-------TASVNLG-DPGPTRRTEGDYLS--------YRELHSM-GRTP 1111

  Fly   720 ------QPDYFRVPSMDD----------ASLQSVQLRSGSGSNGGNQAANSWSTGVNSR-----S 763
                  :|...|..|:|.          .|:..:..|:.|.|: .|.:..|.|...|:|     |
  Rat  1112 VTSGSQRPLSARAFSIDGPSTSRPQSARPSISEIPERTMSVSD-FNYSRTSPSKRPNARVGSEHS 1175

  Fly   764 YVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGS---AASSSSKSSG 825
            .:.||.    .:::|.:..||...:          ::...|...|.::.:.|   |.|||...|.
  Rat  1176 LLDPPG----KSKVPHDWREQVLRH----------IEAKKLEKSMLSRSFSSNLTAVSSSHYGSS 1226

  Fly   826 SSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKN------GQIHVGDQLLAI 884
            ..||         ...|.|.:.:|           .|...||.:.::      |.....|:.::.
  Rat  1227 RDLH---------GSQGSLALNVA-----------DGRGSGGHSFRHPQTSSPGDCCQDDRFMSG 1271

  Fly   885 DEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGS---------------HLPQTQAIYAKV 934
            :::...| .|||.        ||.|  .|....|:||.               |.||     |.|
  Rat  1272 EQNHPLG-ALSHR--------DLRD--SLMKMPLSNGQMGQPLRPQANYSQTHHPPQ-----ASV 1320

  Fly   935 QRRP---------------RSPSANTEASKESGSGNANGGGAVNGNSGSGKPRVFHVTLYKDKVY 984
            .|.|               :.|..:...|...|...|.              :...|.:.||   
  Rat  1321 ARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAK--------------QEIRVRVEKD--- 1368

  Fly   985 DDYGFSVSDGLYER---------GVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTV 1040
            .:.|||:|.|:..|         |:|:.|::..|||..  ||:|.|:|:|.|.....:.:....|
  Rat  1369 PELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKIIQANGYSFINIEHGQAV 1431

  Fly  1041 PLIAAAGDKIEMIMQR 1056
            .|:....:.:|:|:.|
  Rat  1432 SLLKTFHNAVELIIVR 1447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 19/82 (23%)
PDZ_signaling 183..254 CDD:238492 6/70 (9%)
PDZ_signaling 278..375 CDD:238492 17/96 (18%)
PDZ 496..>521 CDD:294084 4/25 (16%)
PDZ_signaling 571..658 CDD:238492 18/133 (14%)
PDZ_signaling 832..913 CDD:238492 15/86 (17%)
PDZ_signaling 973..1055 CDD:238492 26/90 (29%)
ErbinXP_017446668.2 leucine-rich repeat 24..47 CDD:275380
leucine-rich repeat 48..70 CDD:275380
LRR 70..402 CDD:227223
leucine-rich repeat 71..93 CDD:275380
leucine-rich repeat 94..116 CDD:275380
leucine-rich repeat 117..139 CDD:275380
leucine-rich repeat 140..162 CDD:275380
leucine-rich repeat 163..185 CDD:275380
leucine-rich repeat 186..208 CDD:275380
leucine-rich repeat 209..231 CDD:275380
leucine-rich repeat 278..300 CDD:275380
leucine-rich repeat 301..323 CDD:275380
leucine-rich repeat 347..369 CDD:275380
leucine-rich repeat 370..390 CDD:275380
PDZ_signaling 1360..1446 CDD:238492 26/90 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23119
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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