DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and Scrib

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_001178808.1	Gene:	Scrib / 362938	RGDID:	1565055	Length:	1663	Species:	Rattus norvegicus

Alignment Length:	863	Identity:	203/863 - (23%)
Similarity:	301/863 - (34%)	Gaps:	293/863 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 STIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLR 198
            |..|:|..:..|:|..      ||.:|.|    |.|              :|:.|::|.||:::.
  Rat   687 SVKGVSFDQANNLLIE------PARIEEE----ELT--------------LTIVRQTGGLGISIA 727

  Fly   199 GGA--------DYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVS 255
            ||.        |..:.::.|...||....| ::.||:||.|:.|:|......||.:.::..|
  Rat   728 GGKGSTPYKGDDEGIFISRVSEEGPAAHAG-VRVGDKLLEVNGVALQDAEHHEAVEALRGAG--- 788

  Fly   256 GYTNLTIEYDVSVVQSVE----FSMGPLLIEIERPMND---------KLGLVLCNYTAAVP---- 303
                ..::..|...:.||    .::.||     ||.:|         .|.|.|......||
  Rat   789 ----AAVQMRVWRERMVEPENAVTITPL-----RPEDDYSPREWRGGGLRLPLLQPETPVPLRQR 844

  Fly   304 ----------------ASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSI-- 350
                            |.|.||:...:|:     ||:||:.|.....|.|.|.|.|||:||||
  Rat   845 HAACLVRSEKGLGFSIAGGKGSTPYRAGD-----AGIFISRIAEGGAAHRAGTLQVGDRVLSING 904

  Fly   351 -DDTMIEH-------TAFSPDEVMTILDTSTGRGYTQMQIMPAHALARRGHTTLGS--------- 398
             |.|...|       ||.| ..:..:|:..||..|....  |.|:.:....|...:
  Rat   905 VDMTEARHDHAVSLLTAAS-TTISLLLERETGGAYPPSP--PPHSSSTPTATVAATMTTAIPGEP 966

  Fly   399 --PKYSFSTLESRKSSTAGRQRQRFARKSSLPLEN---PACGTPGSTGGSMGTGGIHGSSSLGMG 458
              |:.|.|.|.:             |.:...|:|.   |..|  |..|.|:..|..|.|...|
  Rat   967 LLPRLSPSLLAT-------------ALEGPYPVEEICLPRAG--GPLGLSIVGGSDHSSHPFG-- 1014

  Fly   459 LGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKM 523
                                      |...|    |.|::::|..:|.|.| ::.||||:|:|..
  Rat  1015 --------------------------VQDPG----VFISKVLPRGLAARCG-LRVGDRILAVNGQ 1048

  Fly   524 YSLDA-------AAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGK 581
            ...:|       |.:|..||                |.|.:..|     .|..|:..:.:.:|..
  Rat  1049 DVREATHQEAVSALLRPCLE----------------LCLLVRRD-----PPPPGMRELCIQKAPG 1092

  Fly   582 CGLGLSVSGSSHG-----------GLVISDVKMGSPAHRSGSLRSGDILLAVDQHP---VQHFNV 632
            ..||:|:.|.:.|           |:.||.|.....|.|.|.||.|..||.|:|..   :.|...
  Rat  1093 EKLGISIRGGAKGHAGNPCDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHAEA 1157

  Fly   633 DALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDF-------LPMSSPIYSNCPASGINLGMGMGVS 690
            ..||:..|            .|||:  :|...|       |.:|..:.:|..|:|:.....:...
  Rat  1158 VQLLRSVG------------DTLTV--LVCDGFDTSTTTALEVSPGVIANPFAAGLGHRNSLESI 1208

  Fly   691 TSTDHDLYSSAYVTAGKYADCVS-----------LKSRTPQP---DY---FRVPSMDDASLQSVQ 738
            :|.|.:|....   .||..:..|           ...|..:|   ||   ..|||.  .|||...
  Rat  1209 SSIDRELSPEG---PGKEKELASQTLPWEPESAETTGRNQEPLKLDYRVLAAVPSA--GSLQRGP 1268

  Fly   739 LRSGSG------SNGGNQ---------AANSWSTGVNSRSYVAP-----PNTQSLTTELPEEEDE 783
            ..:..|      |:.|:|         .|.:|     .|...||     |.:.....|||.   .
  Rat  1269 CATTGGKMTEAPSSPGSQQTKPGVIQPLAQAW-----PRDSPAPRGRDGPCSPPSPDELPA---N 1325

  Fly   784 QEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRL----------E 838
            .:|.|     ..:|:|. |..||  ||    ||....:....:|..|:.|..|.          :
  Rat  1326 VKQAY-----RAFAAVP-TVHPP--EN----SATQPPTPGPAASPEQLSFRERQKYFELEVRVPQ 1378

  Fly   839 PKGGLLGITLAGSEDITK 856
            .:|....::|.|::|:.|
  Rat  1379 AEGPPKRVSLVGADDLRK 1396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	4/12 (33%)
		PDZ_signaling	183..254	CDD:238492	22/78 (28%)
		PDZ_signaling	278..375	CDD:238492	39/135 (29%)
		PDZ	496..>521	CDD:294084	10/24 (42%)
		PDZ_signaling	571..658	CDD:238492	27/100 (27%)
		PDZ_signaling	832..913	CDD:238492	7/35 (20%)
		PDZ_signaling	973..1055	CDD:238492
Scrib	NP_001178808.1	LRR_RI	12..232	CDD:238064
		leucine-rich repeat	14..37	CDD:275380
		leucine-rich repeat	38..60	CDD:275380
		LRR	39..405	CDD:227223
		leucine-rich repeat	61..83	CDD:275380
		leucine-rich repeat	84..106	CDD:275380
		leucine-rich repeat	107..129	CDD:275380
		leucine-rich repeat	130..152	CDD:275380
		leucine-rich repeat	153..175	CDD:275380
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..221	CDD:275380
		leucine-rich repeat	268..290	CDD:275380
		LRR_4	289..329	CDD:289563
		leucine-rich repeat	291..313	CDD:275380
		leucine-rich repeat	314..336	CDD:275380
		leucine-rich repeat	360..381	CDD:275380
		PDZ	709..797	CDD:214570	26/113 (23%)
		PDZ_signaling	852..931	CDD:238492	27/84 (32%)
		PDZ_signaling	986..1074	CDD:238492	31/138 (22%)
		PDZ_signaling	1083..1173	CDD:238492	27/103 (26%)
		AbLIM_anchor	1563..>1657	CDD:292800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910