DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip and Ptpn3

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_001059757.1	Gene:	Ptpn3 / 362524	RGDID:	1311363	Length:	1018	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	94/468 - (20%)
Similarity:	152/468 - (32%)	Gaps:	151/468 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KKPIGGCV--PGKSAALKQDQQQQQQQQQESH-----------NNSFNGHHHPPTDTALAPMLSV 58
            ||.|||.|  |....:|..::.:.:.....|.           .:......|...|.....|..:
  Rat   447 KKVIGGMVWNPVMRRSLSVERLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYI 511

  Fly    59 DR----------AMSPAQSE---DSGLAPERGTTYATITLPRNALHLAITFAERNDLSYPP---V 107
            ..          ::||..|:   ....:|.||:     ....|.....:|  :::..|..|   .
  Rat   512 TETEDVFYTYKGSLSPKDSDSEVSQNHSPHRGS-----LSENNPAQSCLT--QKSSSSVSPCSNA 569

  Fly   108 VGSLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQ 172
            .||.:|.|....||   :..|::    |.|.|.::.....|....|....:|
  Rat   570 PGSFSPDGVDQQFL---EDYHKV----TKGGSIEEASQYYCDKNDDGDGYLV------------- 614

  Fly   173 NSLCVTSKLAQITVERESGCLGLTLRGGAD--YPLIVTHVRPHGPVYK-TGRIKPGDRLLRVDNV 234
                    |.:||.::| |..|..|:||.|  .||:|:.:.|..|... ..::..||:::.::..
  Rat   615 --------LIRITPDKE-GRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGR 670

  Fly   235 SLIGKTLAEAQQIIKCG--GH------------VSGYTNLTIEYDVSVV-------------QSV 272
            .:...|..:....||..  .|            |.....:..|.::|.:             .|:
  Rat   671 DISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACPEGGDSL 735

  Fly   273 EFSM---------GPLLIEIERPMNDKLGL------------------VLCNYTAAVPASGSGSS 310
            |.||         |.:||:.|:....|.||                  ||...|..|...|:...
  Rat   736 EGSMELLKKGLESGTVLIQFEQLYRKKPGLAVTFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDY 800

  Fly   311 TPSSGEKIEESAGVFIASILPASIADRCGALS---------VGDQVLSIDDTMIEHTAFSPDEVM 366
            ..:|...:|..|    |:::...||.: |.|.         |.||.||:               :
  Rat   801 INASYVNMEIPA----ANLVNKYIATQ-GPLPHTCAQFWQVVWDQKLSL---------------V 845

  Fly   367 TILDTSTGRGYTQ 379
            .:|.|.|.||.|:
  Rat   846 VMLTTLTERGRTK 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	14/67 (21%)
		PDZ_signaling	183..254	CDD:238492	20/87 (23%)
		PDZ_signaling	278..375	CDD:238492	27/123 (22%)
		PDZ	496..>521	CDD:294084
		PDZ_signaling	571..658	CDD:238492
		PDZ_signaling	832..913	CDD:238492
		PDZ_signaling	973..1055	CDD:238492
Ptpn3	XP_001059757.1	B41	135..327	CDD:214604
		FERM_N	138..201	CDD:286467
		FERM_M	220..327	CDD:278785
		FERM_C_PTPN4_PTPN3_like	321..414	CDD:270010
		PDZ_signaling	613..700	CDD:238492	22/108 (20%)
		PTPc	754..1005	CDD:214550	28/125 (22%)
		PTPc	777..1004	CDD:238006	24/102 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900