DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and Lnx2

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_001101799.1	Gene:	Lnx2 / 360761	RGDID:	1308222	Length:	686	Species:	Rattus norvegicus

Alignment Length:	709	Identity:	151/709 - (21%)
Similarity:	239/709 - (33%)	Gaps:	228/709 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QQQQQQQQQESH-NNSFNGHHHPPTDTALAPMLSVDRAMSPAQSEDSGLAPERGTTYATI--TLP 86
            |...|:...|:| .|...|..|...|..       .|..|.|.::..|   |.|:|....  ..|
  Rat   122 QDVMQRCDLEAHLKNRCLGASHRRVDLE-------RRKTSQAHTQIEG---ETGSTVIDPPGPSP 176

  Fly    87 RNALHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGG 151
            .....|.....|||....|..|.:.:|                       ||.|.       |..
  Rat   177 PETDCLGTVPGERNSTPAPLPVWTEDP-----------------------GLDNP-------AFE 211

  Fly   152 SDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGADYPLI---VTHVRPH 213
            ..|....|:...||||..::...:..|:...|         ||:::.||.:.|||   :..|...
  Rat   212 ESAAADSVQQPLSLPEGEITTIEIHRTNPYIQ---------LGISIVGGNETPLINIVIQEVYRD 267

  Fly   214 GPVYKTGRIKPGDRLLRVDN--VSLIGKTLAEAQQIIKCGGHVSGYTNLTI------------EY 264
            |.:.:.||:..||::|:|:|  :|.:....|.|.....|     ...:||:            ..
  Rat   268 GAIARDGRLLAGDQILQVNNCDISNVSHNYARAVLSQPC-----STLHLTVLRERRFGSRANNHA 327

  Fly   265 DVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASI 329
            |.|..:...|.   :|:. :|...::||:.|...|                    :..||||..:
  Rat   328 DGSAPRDEVFQ---VLLH-KRDSAEQLGIKLVRRT--------------------DEPGVFILDL 368

  Fly   330 LPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMP---AH---AL 388
            |...:|.:.|.||..|:||:|:                        |:...|..|   ||   |.
  Rat   369 LEGGLAAQDGRLSSNDRVLAIN------------------------GHDLKQGTPELAAHIIQAS 409

  Fly   389 ARRGHTTL---GSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIH 450
            ..|.:.|:   |.|:.|..:.|:...|:...|....:|.|| ..:...|.|
  Rat   410 GERVNLTIARPGKPQPSNGSREAGAHSSNHAQPPSHSRPSS-HKDLTRCVT-------------- 459

  Fly   451 GSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGA----VAIAQIVPDSVADRSGCI 511
                       |:.:...|..:.....|:    ||:|..||.:    :.:..:.|.....|.|.|
  Rat   460 -----------CQEKHITVKKEPHESLGM----TVAGGRGSKSGELPIFVTSVPPHGCLARDGRI 509

  Fly   512 QAGDRIVAIN-----KMYSLDAAAMRQLLEGGSSRNGASNGTPA---NWLELEIEFDMPDAVVPA 568
            :.||.::.||     .:...:|.||.:          ||..:||   ..||::|..:...|....
  Rat   510 KRGDVLLNINGIDLTNLSHSEAVAMLK----------ASAASPAVILKALEVQIAEEAAQATEEQ 564

  Fly   569 SGVFS---------------------------VKLLRAGKCGLGLSVSGS-----SHGGLVISDV 601
            .|.||                           :.|.|:.....|.|:.|.     |:....|..:
  Rat   565 PGAFSENEYDASWSPSWVMWLGLPSALHSCHDIVLRRSYLGSWGFSIVGGYEENHSNQPFFIKTI 629

  Fly   602 KMGSPAHRSGSLRSGDILLAVD---QHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTI 657
            .:|:||:..|.|:.||:::||:   ...:.|..:..:|||:...          .|||:
  Rat   630 VLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNK----------VTLTV 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	11/66 (17%)
		PDZ_signaling	183..254	CDD:238492	21/75 (28%)
		PDZ_signaling	278..375	CDD:238492	19/96 (20%)
		PDZ	496..>521	CDD:294084	6/24 (25%)
		PDZ_signaling	571..658	CDD:238492	25/122 (20%)
		PDZ_signaling	832..913	CDD:238492
		PDZ_signaling	973..1055	CDD:238492
Lnx2	NP_001101799.1	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		PDZ	229..315	CDD:214570	24/99 (24%)
		PDZ	335..421	CDD:214570	28/133 (21%)
		PDZ_signaling	462..538	CDD:238492	18/89 (20%)
		PDZ_signaling	595..679	CDD:238492	23/94 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810