DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip and dlg1

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster

Alignment Length:	1032	Identity:	208/1032 - (20%)
Similarity:	322/1032 - (31%)	Gaps:	369/1032 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 DACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGADYPLIVTHVRPHGPVY 217
            |:.||..|.|....||.:.|       |.|||..:::...|.:.::..|:...:...:....||.
  Fly    36 DSSPADDEEEPEEEECLLPQ-------KKAQIRCDQDQPPLVVLVQPSAEAIEVRQEIDDTNPVA 93

  Fly   218 KTGRIK--PGDRLLRV-----------------------DNVSLIGKTLAEAQQIIKCGGHVSGY 257
            ...:..  .||..|.|                       |:|....:....||.:::. ||:...
  Fly    94 VAAKASDMDGDSQLEVMEHQMETVTEPDPEPPKCPTSLRDSVRESVECFYSAQDLLEY-GHMLSS 157

  Fly   258 TNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESA 322
            |::....||......:........|.|.|.:...|...|...:.:......||:..|.|.:....
  Fly   158 TSMVRTPDVESGYFEKSESDASRDEWEGPSSSSSGAARCRLLSGISGLSVSSSSRHSAEGLRMEL 222

  Fly   323 GVFIASI-------LPASIAD-----RCGALSVGDQVLSIDDTMIEH------------------ 357
            ..|...|       |..|.::     :..|.....|...:.|...|.
  Fly   223 SRFRTMIETLERESLEKSQSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERGFWSTIFGQA 287

  Fly   358 -TAFSPDEVMTILDTSTGRGYTQMQIMPAH---ALARRGHTTLGSPK------------------ 400
             .|.|.||...|.|           |..||   .|....|..|..|:
  Fly   288 GLAISQDEEERIAD-----------IQKAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSR 341

  Fly   401 -----------YSFSTLESRKS----------------------STAGRQRQRF----------- 421
                       |..:.|:..||                      ..|..||.|.
  Fly   342 LFQALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIESDTENAKEPT 406

  Fly   422 ----------ARKSSLPLENPACGTPGSTGGSMGTGG---IHGSSS-LGMGLGLCRAESFPVLLD 472
                      .::||   .:|....|....||....|   ::|..| |...:.|.|..|
  Fly   407 VEQQQKQQQAQQRSS---RSPQQQNPQQQQGSKSRSGSQTVNGDDSWLYEDIQLERGNS------ 462

  Fly   473 CSHGAGIILSETVSGS------GGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLD---A 528
               |.|.    :::|.      |...::.|.:::....|...|.:...|.||::|.:..:|   |
  Fly   463 ---GLGF----SIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHA 520

  Fly   529 AAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASG---------------VFSVKLLR 578
            :|:..|.:.|            |.::|.::.....|..||:|               |..:.|::
  Fly   521 SAVDALKKAG------------NVVKLHVKRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLVK 573

  Fly   579 AGKCGLGLSVS---GSSH----GGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALL 636
            .|| |||.|::   |:.|    .|:.::.:..|..|...|.|..||.|:||
  Fly   574 GGK-GLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAV-------------- 623

  Fly   637 KEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSA 701
            :..|..:|..:.:.:....|:|.|                 ...:.|.:|     .|.| |.:||
  Fly   624 RTNGSEKNLENVTHELAVATLKSI-----------------TDKVTLIIG-----KTQH-LTTSA 665

  Fly   702 YVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNG---GNQAANSWSTGVNSRS 763
                                                   ||.|..|   |.|.:.|.|....|:|
  Fly   666 ---------------------------------------SGGGGGGLSSGQQLSQSQSQLATSQS 691

  Fly   764 YV-------APPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSS 821
            ..       |.|...|.:||            ||   :||||.:..|..||      |:..:.|:
  Fly   692 QSQVHQQQHATPMVNSQSTE------------PG---SRYASTNVLAAVPP------GTPRAVST 735

  Fly   822 KSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDE 886
            :........|  |::..|:|  ||..:.|.|| .:.|.:|.::.||.|....::..|||||
  Fly   736 EDITREPRTI--TIQKGPQG--LGFNIVGGED-GQGIYVSFILAGGPADLGSELKRGDQLL---- 791

  Fly   887 HSVQGMPLSHAT-----SLLQNLGDLVDLKILRSHDLANGSHLPQTQAIYAKVQRRPRSPS---A 943
             ||..:.|:|||     ..|:..|.:|.|       ||               |.||...:   |
  Fly   792 -SVNNVNLTHATHEEAAQALKTSGGVVTL-------LA---------------QYRPEEYNRFEA 833

  Fly   944 NTEASKESGSGNANGGGAVNGNSGSGKPRVFHVTLYKDKVYDDYGFSVSDGLYERGV 1000
            ..:..|:..:..|.|.|.:...:   :.|..:|     :...||..:..|||..||:
  Fly   834 RIQELKQQAALGAGGSGTLLRTT---QKRSLYV-----RALFDYDPNRDDGLPSRGL 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084
		PDZ_signaling	183..254	CDD:238492	15/95 (16%)
		PDZ_signaling	278..375	CDD:238492	23/127 (18%)
		PDZ	496..>521	CDD:294084	6/24 (25%)
		PDZ_signaling	571..658	CDD:238492	23/93 (25%)
		PDZ_signaling	832..913	CDD:238492	28/85 (33%)
		PDZ_signaling	973..1055	CDD:238492	8/28 (29%)
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	7/55 (13%)
		PDZ	454..540	CDD:214570	21/110 (19%)
		PDZ_signaling	566..655	CDD:238492	26/120 (22%)
		PDZ_signaling	742..820	CDD:238492	29/94 (31%)
		SH3_DLG-like	862..922	CDD:212795	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447378
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23119
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030