DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and PsGEF

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_996333.4 Gene:PsGEF / 31224 FlyBaseID:FBgn0264598 Length:2777 Species:Drosophila melanogaster


Alignment Length:1110 Identity:223/1110 - (20%)
Similarity:361/1110 - (32%) Gaps:341/1110 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 HHHPPTDTALAPMLSVDRAMS----PAQSEDSGLAPERGTTYATITLPRNALHL-AITFAERNDL 102
            |....|.|....::|:.|..|    |..:..|..|.....|.::|...:..||| .:||::.   
  Fly   754 HTLATTATGTTTVMSLQRTTSTRIQPLANSMSRPATACSGTTSSIEAAKRRLHLPQVTFSKE--- 815

  Fly   103 SYPPVVGS--------------------------LNPVGHAADFLAPGDRLHQIDGISTIGLSNQ 141
            |..||..:                          :.|:|...|.::|.|.......|..:....:
  Fly   816 SIVPVTDNRRRFLLQLISREQNFTAALHFGVDRFVQPLGERKDLISPNDHRTLFQNIDELLRIAE 880

  Fly   142 KVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGADYPLI 206
            .::..||:  ||......::.::         |....||...|....:..|.|:.   .||. ::
  Fly   881 DILEQLCS--SDQQDQEPQMNFA---------SRVYLSKTTAICAAYKKYCNGIK---RADC-VL 930

  Fly   207 VTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIE-------- 263
            |...|..|..:.....:|.....|.|....|.:.|...::|:|....::|..::..|        
  Fly   931 VNKSRQTGSEFIAFITEPAVPRKRPDLTMFIHRPLQHFREILKLMQLLAGNCHVDTEEHKNFSTV 995

  Fly   264 --------YDVSVVQSVEFSMG---PLLIEIERPMNDKLGLVLCN-YTAAVPASG---SGSSTPS 313
                    .:::|...:...:|   |||  ..:.:..::....|. :|.||....   .|..:..
  Fly   996 INELQAAYREITVSSGLMEPLGEGRPLL--TLQDLESRMVFTKCKPFTLAVQGRQWIFGGDLSRV 1058

  Fly   314 SGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIE--HTAFSPDEVMTILDTSTGR- 375
            .|..::....:..:.|:..:...|...|.:.::.:.|.:.:..  |......|....:|.: || 
  Fly  1059 EGRSVKPYWTLLFSDIIVFAKVSRDRVLFITEEPIPIANVVDSCFHMRKKTTEFRLTVDPN-GRL 1122

  Fly   376 -----GYTQMQI--MPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRF---ARKSSLPLE 430
                 ||....:  .|... |||....|.:|     :||.:.......|||.|   |...|.||.
  Fly  1123 AESPTGYCAPDLTRTPKRG-ARRKSLILRAP-----SLELKAVWQNLLQRQIFLVNAALGSTPLS 1181

  Fly   431 NPACGTP------------GSTGGSMG--------------------TGGIHGSSSLGMGLGLCR 463
            :| ..:|            |.|..|||                    |...||......|:...|
  Fly  1182 SP-LDSPDVLNTLVPLSDIGLTTASMGSMKLPSLDSIHLKQQQKQQRTNNSHGHVHSATGVATDR 1245

  Fly   464 AESFPVLLDCSHG--AGI-----------------ILSETVSGSGGSGAVAIAQIVPDSVADRSG 509
            .      .|.|||  .||                 ||::|  |:..|.|:.:|..:...: |:. 
  Fly  1246 T------ADRSHGHNHGIHGGHVEQIELLIDEKCRILNKT--GTPKSSALHLANWMKGQL-DKQ- 1300

  Fly   510 CIQAGDRIVAINKMYSLDAAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSV 574
              |...|:.||.:.....:|...||:....|.   .:.....|...::|             ...
  Fly  1301 --QQQARLAAIARSQENVSAEDEQLIFNSDSE---QDERITYWTRQQLE-------------KRT 1347

  Fly   575 KLLRAGKCGLGLSVSGSSHGGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEE 639
            |.|...|...||| :..:.||..:|.|:..|.:..|                    ::.:..:.|
  Fly  1348 KELNLAKENGGLS-ARPNFGGKRLSGVEELSMSATS--------------------DIYSTSEAE 1391

  Fly   640 GRSQ--NPSHSSSDFTTLTIKR--IVLPDFLPMSSPIYSNCPAS---GINLGMGMGVSTSTDHDL 697
            |.:.  :.|||::..:.:|::.  ||| |.|.:....:.||..|   |...|.|.||:.|     
  Fly  1392 GVTSVISQSHSTTSDSQITVRSSPIVL-DKLAVCRHCHKNCQQSGPGGARPGGGGGVNNS----- 1450

  Fly   698 YSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQL-------RSGSGSNGGNQAANSW 755
             ||..|..     |.|||.:..|....|...:.:....:.::       |:|:|:......::|.
  Fly  1451 -SSTPVLL-----CNSLKVQHSQSSPNRCCKLSNGIAGATEMANPKNSNRTGTGTGSVTSMSSST 1509

  Fly   756 STGVNSRSYVAPP------NTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYG 814
            .||..|...||..      :|:|...:|..:|..|.|        ..|:.|.....|        
  Fly  1510 ITGELSSKVVASSSRRETGDTESDVAQLITDEISQSQ--------SEATDDSVGAMP-------- 1558

  Fly   815 SAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGD 879
                :||:|:|.                       |:..||                      |.
  Fly  1559 ----NSSRSAGE-----------------------GNPVIT----------------------GS 1574

  Fly   880 QLLAIDEH-SVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLP-----QTQAIYAKVQRRP 938
            :|..:|.. ||..:|..|.                 |..:..||..|     :|:.:....|..|
  Fly  1575 RLRHLDPPVSVSSLPNGHC-----------------SAGVGGGSPKPLPPPRRTRVVAQMCQEPP 1622

  Fly   939 RSPSANTEA-----------------SKESGSGNANGGGAVNGNSGS-------GKPRVF-HVTL 978
            | |.||.:.                 :|.||||:|.|.|:|.|:...       ..|..| |..|
  Fly  1623 R-PKANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGGSPAKYAACHCRCTPEDFTHAQL 1686

  Fly   979 YKDKV 983
            ..||:
  Fly  1687 SPDKM 1691

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 15/91 (16%)
PDZ_signaling 183..254 CDD:238492 15/70 (21%)
PDZ_signaling 278..375 CDD:238492 16/102 (16%)
PDZ 496..>521 CDD:294084 5/24 (21%)
PDZ_signaling 571..658 CDD:238492 18/88 (20%)
PDZ_signaling 832..913 CDD:238492 10/81 (12%)
PDZ_signaling 973..1055 CDD:238492 5/12 (42%)
PsGEFNP_996333.4 DUF4799 <102..209 CDD:292674
C2 286..>381 CDD:278593
PDZ_signaling 644..716 CDD:238492
RhoGEF 831..1000 CDD:295373 30/183 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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