DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Gopc

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_001101101.2 Gene:Gopc / 309774 RGDID:1309512 Length:463 Species:Rattus norvegicus


Alignment Length:468 Identity:104/468 - (22%)
Similarity:168/468 - (35%) Gaps:132/468 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   580 GKCGLGLSVSGSSHGGLVISDVKMG-SPAHRSGSLRSGDILLAVDQHPVQHF-NVDALLKE---- 638
            |.|..|   :||..||   :...:| ||    |.:.....|..:::...:.| :||.||.|    
  Rat     5 GPCPAG---AGSGPGG---ASCPVGVSP----GGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPD 59

  Fly   639 ------EGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTD--- 694
                  ||| |..:..||.|..|..|...:       |.|.....|..::|...:   |.|.   
  Rat    60 QADITYEGR-QKMTSLSSCFAQLCHKAQTV-------SQINHKLEAQLVDLRSEL---TETQAEK 113

  Fly   695 -------HD----LYSS---AYVTAGKYADCVSLKSRTPQPDYFRVPSMDD-------------- 731
                   ||    |:|:   .:...|:..|..::|::      ..|.||:|              
  Rat   114 VVLEKEVHDQLLQLHSTQLQLHAKTGQSVDSGAIKAK------LSVHSMEDLERELEANKTEKVK 172

  Fly   732 -ASLQS-VQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTEL----------------P 778
             |.|:: |:|....     |:|.......:.:..|.|....:.|..||                |
  Rat   173 EARLEAEVKLLRKE-----NEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGP 232

  Fly   779 EEEDEQEQMYPGYELNRYASV--DCTA---LPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLE 838
            ..:....|:.....|:|:.:|  .|..   |..||:... |....|..||.|....:.:..::.:
  Rat   233 AHDKLWNQLEAEIHLHRHKTVIRACRGRQDLKRPMQAPP-GHDQDSLKKSQGVGPIRKVLLLKED 296

  Fly   839 PKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLL-Q 902
            .:|  |||::.|.::....|.||.:..|..|.:.|.:||||.:||::..:::......|.::| |
  Rat   297 HEG--LGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAVLAVNGVNLRDTKHKEAVTILSQ 359

  Fly   903 NLGDLVDLKILRSHDLANGSHLPQTQAIYAKVQRRPRSPSANTEASKESG----------SGNAN 957
            ..|::                  :.:.:|  |.....|...|.|...|||          .|..|
  Rat   360 QRGEI------------------EFEVVY--VAPEVDSDDENVEYEDESGHRYRLYLDELEGGGN 404

  Fly   958 GGGAVNGNSGSGK 970
            .|.:...:||..|
  Rat   405 SGASCKDSSGEMK 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492
PDZ 496..>521 CDD:294084
PDZ_signaling 571..658 CDD:238492 26/89 (29%)
PDZ_signaling 832..913 CDD:238492 21/81 (26%)
PDZ_signaling 973..1055 CDD:238492
GopcNP_001101101.2 SMC_prok_B <35..>215 CDD:274008 42/201 (21%)
PDZ_signaling 287..369 CDD:238492 21/101 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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