DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Dlg4

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_062567.1 Gene:Dlg4 / 29495 RGDID:68424 Length:724 Species:Rattus norvegicus


Alignment Length:497 Identity:95/497 - (19%)
Similarity:173/497 - (34%) Gaps:176/497 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   605 SPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMS 669
            ||||......|..:::..|......:.:..         |.:....::..:|::|          
  Rat    25 SPAHLPNQANSPPVIVNTDTLEAPGYELQV---------NGTEGEMEYEEITLER---------- 70

  Fly   670 SPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSM-DDAS 733
                      | |.|:|..::..||:                               |.: ||.|
  Rat    71 ----------G-NSGLGFSIAGGTDN-------------------------------PHIGDDPS 93

  Fly   734 LQSVQ-LRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYA 797
            :...: :..|:.:..|....|.....||                   |.|.:|            
  Rat    94 IFITKIIPGGAAAQDGRLRVNDSILFVN-------------------EVDVRE------------ 127

  Fly   798 SVDCTALPPPMENKVYGSAASSSSKSSGSSLH----------QIIFTVRL--EPKGGLLGITLA- 849
                          |..|||..:.|.:||.:.          :.:..::|  .|||  ||.::| 
  Rat   128 --------------VTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKG--LGFSIAG 176

  Fly   850 --GSEDI--TKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDL 910
              |::.|  ..||.::.::|||.|||:|::.:||::||::...::.:....|.:.|:|..|:|.|
  Rat   177 GVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYL 241

  Fly   911 KILR---------------------------SHDLANGSHLPQTQAIYAKVQRRPRSPSANTEAS 948
            |:.:                           ||....|:..|....        |.||...:..:
  Rat   242 KVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMT--------PTSPRRYSPVA 298

  Fly   949 KESGSGNANGGGAVNGNSGSGKPRVFHVTLYKDKVYDDYGFSVSDGLYERGVFINRIRSGGPADM 1013
            |:          .:.......:||  .:.:::...  ..||::..|....|:||:.|.:|||||:
  Rat   299 KD----------LLGEEDIPREPR--RIVIHRGST--GLGFNIVGGEDGEGIFISFILAGGPADL 349

  Fly  1014 CGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQ 1055
            .|.|:..|:|:.||.:..::.........:..||..:.:|.|
  Rat   350 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492
PDZ 496..>521 CDD:294084
PDZ_signaling 571..658 CDD:238492 8/52 (15%)
PDZ_signaling 832..913 CDD:238492 29/87 (33%)
PDZ_signaling 973..1055 CDD:238492 21/81 (26%)
Dlg4NP_062567.1 MAGUK_N_PEST 10..64 CDD:287565 7/47 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..35 4/9 (44%)
PDZ 65..149 CDD:278991 27/180 (15%)
PDZ 160..244 CDD:278991 29/85 (34%)
PDZ_assoc 245..312 CDD:287558 8/84 (10%)
PDZ 310..394 CDD:214570 24/86 (28%)
SH3_DLG4 430..495 CDD:212963
Guanylate_kin 533..711 CDD:279019
GuKc 544..710 CDD:214504
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23119
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

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