DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and WHRN

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_011516787.1	Gene:	WHRN / 25861	HGNCID:	16361	Length:	918	Species:	Homo sapiens

Alignment Length:	859	Identity:	186/859 - (21%)
Similarity:	286/859 - (33%)	Gaps:	265/859 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 LGLTLRGGADY--PLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIK------ 249
            ||.::|||:::  .:.|:.|.|.....|.| ::.||::|||::.||...|.|||.:.:|
Human   152 LGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKALKGSKKLV 215

  Fly   250 ---------CGGHVSGYTNLTIE---YDVSVVQSVEFSMGPLLIEIERPMND-----------KL 291
                     .||:|:.:....::   ..:|....:....|..|.:.|.....           |:
Human   216 LSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKV 280

  Fly   292 GLVLCNYTAAVPASGSGSS---TPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDT 353
            .|||          |.|.|   |...|  .|...|::|..:.|.|.|:..| |.||||:|.::..
Human   281 NLVL----------GDGRSLGLTIRGG--AEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGR 332

  Fly   354 M---IEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAG 415
            .   |.|     ||.:.:|.:|      :..|:....:.|..|..        :|::..|...:.
Human   333 SFLNILH-----DEAVRLLKSS------RHLILTVKDVGRLPHAR--------TTVDETKWIASS 378

  Fly   416 RQRQRFARKSSL--PLENPACGTPGSTGGSMGT-------------------------------- 446
            |.|:..|..:..  .|.......||...|..|:
Human   379 RIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGNQTRVLLEEQARHLLNEQEHATMA 443

  Fly   447 -------GGIHGSSSLGMGLG--LCRAESFPVLLDC------------SH--------------- 475
                   ||.....:|.|.|.  |.....|.:|.:.            .|
Human   444 YYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVRGTISPQDLERFDHLVLRREIESMKARQP 508

  Fly   476 ---GAG-----IILSETVSGSGGSG---AVAIAQ----IVPDSVADRSGCIQAGDRIVA-INKMY 524
               |||     :..|:|.|.:|..|   .|:.|:    .:.|.:.:.....:.|:.:.. ||.:.
Human   509 PGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSSARERLLWLIDLMENTLDLEETGEAVQGNINALP 573

  Fly   525 SLDAAAMRQLLEGGSSRNGASNGTP---ANWLEL-------EIEFDMPDAVVPASG-VFSVKLLR 578
            .:....:|...:|.||........|   .|.|.|       ..:...|.::...|| |||....|
Human   574 DVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSAPQNR 638

  Fly   579 AGKCGLGLSVSGSSHGGLVISDVKMG-SPAHRSGSLRSGDILLA-VDQHPVQHFNVDALLKEEGR 641
            :...|...:...||...|..|.:... |||:.| |.|..|..|| |:|||:..|         .|
Human   639 SPPAGTAPTPGTSSAQDLPSSPIYASVSPANPS-SKRPLDAHLALVNQHPIGPF---------PR 693

  Fly   642 SQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAG 706
            .|:|.|..|.....|:....|....|...|     ..:|.|....|
Human   694 VQSPPHLKSPSAEATVAGGCLLPPSPSGHP-----DQTGTNQHFVM------------------- 734

  Fly   707 KYADCVSLKSRTPQPDYFRV---PSMDDASLQSVQLRSG------SGSNGGNQAANSWSTGVNSR 762
                 |.:.....:||...|   |....||..|....||      ||.:.|...|::...|..|.
Human   735 -----VEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGEAEASAPGRGRQSV 794

  Fly   763 SYVAPPNTQSLTT-ELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGS 826
            |      |:|.:: |||..|                      .|....||..|....:|:
Human   795 S------TKSRSSKELPRNE----------------------RPTDGANKPPGLLEPTST----- 826

  Fly   827 SLHQIIFTVRLEPKGGLLGITLAGS----EDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEH 887
                   .||::.....|||.:.|.    :.:.:.:||.   .||.||..||:.||..:|.::..
Human   827 -------LVRVKKSAATLGIAIEGGANTRQPLPRIVTIQ---RGGSAHNCGQLKVGHVILEVNGL 881

  Fly   888 SVQGMPLSHATSLL 901
            :::|.....|..::
Human   882 TLRGKEHREAARII 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084
		PDZ_signaling	183..254	CDD:238492	24/77 (31%)
		PDZ_signaling	278..375	CDD:238492	30/113 (27%)
		PDZ	496..>521	CDD:294084	3/29 (10%)
		PDZ_signaling	571..658	CDD:238492	29/88 (33%)
		PDZ_signaling	832..913	CDD:238492	19/74 (26%)
		PDZ_signaling	973..1055	CDD:238492
WHRN	XP_011516787.1	HN_L-whirlin_R1_like	37..112	CDD:259822
		PDZ_signaling	138..215	CDD:238492	22/63 (35%)
		PDZ_signaling	277..357	CDD:238492	29/103 (28%)
		HN_L-whirlin_R2_like	419..499	CDD:259823	9/79 (11%)
		PDZ_signaling	827..898	CDD:238492	19/72 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900