DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and Grip2

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_006506166.1	Gene:	Grip2 / 243547	MGIID:	2681173	Length:	1049	Species:	Mus musculus

Alignment Length:	1241	Identity:	327/1241 - (26%)
Similarity:	465/1241 - (37%)	Gaps:	479/1241 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 DTALAPMLSVDRAMSPAQSEDSGLAPE--RGTTYATITLPRNALHLAITFAERNDLSYPPVVGSL 111
            |||.|....|.|..|         .||  ||.|...: :.|....|.:|.:...|....|.|.:|
Mouse    36 DTAGADGALVCRRQS---------IPEEFRGITMVEL-IKREGSTLGLTISGGTDKDGKPRVSNL 90

  Fly   112 NPVGHAA--DFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNS 174
            .|.|.||  |.|..||.:..::||....|.:.:::.:|...|.   ..::|:||.||. ...:|:
Mouse    91 RPGGLAARSDLLNVGDYIRSVNGIHLTRLRHDEIITLLKNVGE---RVVLEVEYELPP-PAPENN 151

  Fly   175 LCVTSKLAQITVERESGCLGLTLRGGA------DYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDN 233
            ..:.||...:::.:|....|..|||||      ..||::|:|||.||..:.|.:|.|||||.:|.
Mouse   152 PRIISKTVDVSLYKEGNSFGFVLRGGAHEDLHKSRPLVLTYVRPGGPADREGSLKVGDRLLSIDG 216

  Fly   234 VSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNY 298
            :.|.|.:.|.|...::...|.:.:   .:||||:...:|..:.|||::||.:.....||:.|
Mouse   217 IPLHGASHATAIATLQQCSHEALF---QVEYDVATPDTVANASGPLVVEIAKTPGSALGISL--- 275

  Fly   299 TAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPD 363
                 .:||..:.|:          :.|..|.|||:.||.|||..||.:|:||.|..||.:..
Mouse   276 -----TTGSHRNKPA----------ITIDRIKPASVVDRSGALHAGDHILAIDGTSTEHCSLV-- 323

  Fly   364 EVMTILDTSTGRGYTQMQIMPA-------------------------------HALARRGHT--- 394
            |...:|.:.|.:  .:::|:|:                               |: .|..|.
Mouse   324 EATKLLASVTEK--VRLEILPSPQSRRPLKPPEAVRIQRSEQLHRWDPSAPSCHS-PRPSHCRAP 385

  Fly   395 --TLGSPKYSFSTLESRKSS------------------------TAGRQRQRFARK---SSLPLE 430
              ..|.|..|.|...:..||                        ||||:|||  ||   |||.|
Mouse   386 TWAAGGPDQSRSVSSTPFSSPTMNPAFPCANASTLPRGPMSPRTTAGRRRQR--RKEHRSSLSL- 447

  Fly   431 NPACGTPGSTGGSMGTGG--IH---------GSSSLGMGLGLCRAESFPVLLDCSHGAGIILSET 484
                     ...::|.||  :|         |....|.||.|              ..||..:||
Mouse   448 ---------ASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQL--------------QGGIFATET 489

  Fly   485 VSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAA--AMRQLLEGGSSRNGASNG 547
            :     |....:..|.|||.|:|.|.:|.|||::|||.:.:.|..  ...|||     |:.|.
Mouse   490 L-----SSPPLVRFIEPDSPAERCGLLQVGDRVLAINGIATEDGTMEEANQLL-----RDAAL-- 542

  Fly   548 TPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSH---GGLVISDVKMGSPAHR 609
              |..:.||||||:.::|:|:||.|.|||.:.....||:::|.:|.   ..|:|||:|.||.|||
Mouse   543 --ARKVVLEIEFDVAESVIPSSGTFHVKLPKRRGVELGITISSASRKRGEPLIISDIKKGSVAHR 605

  Fly   610 SGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYS 674
            :|:|..||.|||:|...:.|
Mouse   606 TGTLEPGDKLLAIDNIRLDH--------------------------------------------- 625

  Fly   675 NCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQL 739
             ||                    ...|.....:..|.|.||.|..:
Mouse   626 -CP--------------------MEDAVQILRQCEDLVKLKIRKDE------------------- 650

  Fly   740 RSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTAL 804
                                                   :..||||
Mouse   651 ---------------------------------------DNSDEQE------------------- 657

  Fly   805 PPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIA 869
                              |||:    :.:||.|:..||.||||::|:|:....|.||||.:.|:|
Mouse   658 ------------------SSGA----VSYTVELKRYGGPLGITISGTEEPFDPIIISGLTKRGLA 700

  Fly   870 HKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHD----------------- 917
            .:.|.|||||::|||:..|::|.|||.|..|||..|:.|.|||.:..|
Mouse   701 ERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDV 765

  Fly   918 ------------LA----------------------------NGSHLPQTQAIYAKVQR------ 936
                        ||                            .||:.||........|.
Mouse   766 DEDPPEALKGGLLATRFSPAVPSVDSAVESWGSSATDGGFGGTGSYTPQVAVRSVTPQEWRPSRL 830

  Fly   937 -------RPRSPSANTEASKES--------------GSGNANGGG-------------------- 960
                   .||..|.....|.||              ..|.|...|
Mouse   831 KSSPPPLEPRRTSYTPGPSDESFPEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLESCGQSEL 895

  Fly   961 ----------------AVNGNSGSGKP-----------------------RVFHVTLYKDKVYDD 986
                            ||:|..|| :|                       .:..|||:||.|.:|
Mouse   896 LRELEASIMTGTVHSVAVDGRPGS-RPWRRSREVRTSPEDLQELLLPTPLEMHRVTLHKDPVRND 959

  Fly   987 YGFSVSDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIE 1051
            :||||||||.|:||:::.:|..|||.:.| |:||||::|||.::|:||||||.|||:|.|||.:|
Mouse   960 FGFSVSDGLLEKGVYVHTVRIDGPAQLGG-LQPFDRLLQVNHVRTRDFDCCLAVPLLAEAGDILE 1023

  Fly  1052 MIMQRS 1057
            :::.|:
Mouse  1024 LVVSRN 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	18/66 (27%)
		PDZ_signaling	183..254	CDD:238492	27/76 (36%)
		PDZ_signaling	278..375	CDD:238492	31/96 (32%)
		PDZ	496..>521	CDD:294084	12/24 (50%)
		PDZ_signaling	571..658	CDD:238492	27/89 (30%)
		PDZ_signaling	832..913	CDD:238492	40/80 (50%)
		PDZ_signaling	973..1055	CDD:238492	46/81 (57%)
Grip2	XP_006506166.1	PDZ_signaling	58..140	CDD:238492	22/85 (26%)
		PDZ_signaling	160..243	CDD:238492	28/85 (33%)
		PDZ_signaling	258..341	CDD:238492	31/104 (30%)
		PDZ_signaling	463..551	CDD:238492	33/115 (29%)
		PDZ_signaling	564..647	CDD:238492	34/148 (23%)
		PDZ_signaling	664..744	CDD:238492	40/79 (51%)
		PDZ_signaling	947..1026	CDD:238492	46/79 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6691
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	390	1.000	Inparanoid score	I1978
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46788
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003379
OrthoInspector	1	1.000	-	-		otm44099
orthoMCL	1	0.900	-	-		OOG6_103747
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5842
SonicParanoid	1	1.000	-	-		X2278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.760