Protein Alignment Grip and Grip2

DIOPT Version :10

• Sequence 1: NP_572285.2
• Gene: Grip / 50391
• FlyBaseID: FBgn0029830
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: XP_006506166.1
• Gene: Grip2 / 243547
• MGIID: 2681173
• Length: 1049
• Species: Mus musculus
• Alignment Length: 1241
• Identity: 327/1241 - (26%)
• Similarity: 465/1241 - (37%)
• Gaps: 479/1241 - (38%)

  Fly    49 DTALAPMLSVDRAMSPAQSEDSGLAPE--RGTTYATITLPRNALHLAITFAERNDLSYPPVVGSL 111
            |||.|....|.|..|         .||  ||.|...: :.|....|.:|.:...|....|.|.:|
Mouse    36 DTAGADGALVCRRQS---------IPEEFRGITMVEL-IKREGSTLGLTISGGTDKDGKPRVSNL 90

  Fly   112 NPVGHAA--DFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNS 174
            .|.|.||  |.|..||.:..::||....|.:.:::.:|...|.   ..::|:||.||. ...:|:
Mouse    91 RPGGLAARSDLLNVGDYIRSVNGIHLTRLRHDEIITLLKNVGE---RVVLEVEYELPP-PAPENN 151

  Fly   175 LCVTSKLAQITVERESGCLGLTLRGGA------DYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDN 233
            ..:.||...:::.:|....|..|||||      ..||::|:|||.||..:.|.:|.|||||.:|.
Mouse   152 PRIISKTVDVSLYKEGNSFGFVLRGGAHEDLHKSRPLVLTYVRPGGPADREGSLKVGDRLLSIDG 216

  Fly   234 VSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNY 298
            :.|.|.:.|.|...::...|.:.:   .:||||:...:|..:.|||::||.:.....||:.|
Mouse   217 IPLHGASHATAIATLQQCSHEALF---QVEYDVATPDTVANASGPLVVEIAKTPGSALGISL--- 275

  Fly   299 TAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPD 363
                 .:||..:.|:          :.|..|.|||:.||.|||..||.:|:||.|..||.:..
Mouse   276 -----TTGSHRNKPA----------ITIDRIKPASVVDRSGALHAGDHILAIDGTSTEHCSLV-- 323

  Fly   364 EVMTILDTSTGRGYTQMQIMPA-------------------------------HALARRGHT--- 394
            |...:|.:.|.:  .:::|:|:                               |: .|..|.
Mouse   324 EATKLLASVTEK--VRLEILPSPQSRRPLKPPEAVRIQRSEQLHRWDPSAPSCHS-PRPSHCRAP 385

  Fly   395 --TLGSPKYSFSTLESRKSS------------------------TAGRQRQRFARK---SSLPLE 430
              ..|.|..|.|...:..||                        ||||:|||  ||   |||.|
Mouse   386 TWAAGGPDQSRSVSSTPFSSPTMNPAFPCANASTLPRGPMSPRTTAGRRRQR--RKEHRSSLSL- 447

  Fly   431 NPACGTPGSTGGSMGTGG--IH---------GSSSLGMGLGLCRAESFPVLLDCSHGAGIILSET 484
                     ...::|.||  :|         |....|.||.|              ..||..:||
Mouse   448 ---------ASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQL--------------QGGIFATET 489

  Fly   485 VSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAA--AMRQLLEGGSSRNGASNG 547
            :     |....:..|.|||.|:|.|.:|.|||::|||.:.:.|..  ...|||     |:.|.
Mouse   490 L-----SSPPLVRFIEPDSPAERCGLLQVGDRVLAINGIATEDGTMEEANQLL-----RDAAL-- 542

  Fly   548 TPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSH---GGLVISDVKMGSPAHR 609
              |..:.||||||:.::|:|:||.|.|||.:.....||:::|.:|.   ..|:|||:|.||.|||
Mouse   543 --ARKVVLEIEFDVAESVIPSSGTFHVKLPKRRGVELGITISSASRKRGEPLIISDIKKGSVAHR 605

  Fly   610 SGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYS 674
            :|:|..||.|||:|...:.|
Mouse   606 TGTLEPGDKLLAIDNIRLDH--------------------------------------------- 625

  Fly   675 NCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQL 739
             ||                    ...|.....:..|.|.||.|..:
Mouse   626 -CP--------------------MEDAVQILRQCEDLVKLKIRKDE------------------- 650

  Fly   740 RSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTAL 804
                                                   :..||||
Mouse   651 ---------------------------------------DNSDEQE------------------- 657

  Fly   805 PPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIA 869
                              |||:    :.:||.|:..||.||||::|:|:....|.||||.:.|:|
Mouse   658 ------------------SSGA----VSYTVELKRYGGPLGITISGTEEPFDPIIISGLTKRGLA 700

  Fly   870 HKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHD----------------- 917
            .:.|.|||||::|||:..|::|.|||.|..|||..|:.|.|||.:..|
Mouse   701 ERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDV 765

  Fly   918 ------------LA----------------------------NGSHLPQTQAIYAKVQR------ 936
                        ||                            .||:.||........|.
Mouse   766 DEDPPEALKGGLLATRFSPAVPSVDSAVESWGSSATDGGFGGTGSYTPQVAVRSVTPQEWRPSRL 830

  Fly   937 -------RPRSPSANTEASKES--------------GSGNANGGG-------------------- 960
                   .||..|.....|.||              ..|.|...|
Mouse   831 KSSPPPLEPRRTSYTPGPSDESFPEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLESCGQSEL 895

  Fly   961 ----------------AVNGNSGSGKP-----------------------RVFHVTLYKDKVYDD 986
                            ||:|..|| :|                       .:..|||:||.|.:|
Mouse   896 LRELEASIMTGTVHSVAVDGRPGS-RPWRRSREVRTSPEDLQELLLPTPLEMHRVTLHKDPVRND 959

  Fly   987 YGFSVSDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIE 1051
            :||||||||.|:||:::.:|..|||.:.| |:||||::|||.::|:||||||.|||:|.|||.:|
Mouse   960 FGFSVSDGLLEKGVYVHTVRIDGPAQLGG-LQPFDRLLQVNHVRTRDFDCCLAVPLLAEAGDILE 1023

  Fly  1052 MIMQRS 1057
            :::.|:
Mouse  1024 LVVSRN 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ_canonical	<96..163	CDD:483948	18/68 (26%)
		PDZ2_GRIP1-2-like	180..265	CDD:467169	30/90 (33%)
		PDZ3_GRIP1-2-like	277..384	CDD:467172	33/106 (31%)
		degP_htrA_DO	<491..659	CDD:273938	59/172 (34%)
		PDZ_canonical	572..>623	CDD:483948	25/53 (47%)
		PDZ6_GRIP1-2-like	830..914	CDD:467171	41/83 (49%)
		PDZ7_GRIP1-2-like	971..1056	CDD:467173	47/107 (44%)
Grip2	XP_006506166.1	PDZ1_GRIP1-2-like	59..141	CDD:467175	22/85 (26%)
		PDZ2_GRIP1-2-like	157..245	CDD:467169	30/90 (33%)
		PDZ3_GRIP1-2-like	257..342	CDD:467172	33/106 (31%)
		PDZ4_GRIP1-2-like	457..557	CDD:467174	38/127 (30%)
		PDZ5_GRIP1-2-like	565..648	CDD:467170	34/148 (23%)
		PDZ6_GRIP1-2-like	661..745	CDD:467171	41/87 (47%)
		PDZ7_GRIP1-2-like	944..1028	CDD:467173	46/84 (55%)