DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and Ptpn21

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_001139671.1 Gene:Ptpn21 / 24000 MGIID:1344406 Length:1176 Species:Mus musculus


Alignment Length:559 Identity:106/559 - (18%)
Similarity:172/559 - (30%) Gaps:226/559 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   518 VAINKMYSLD-------AAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPA-----SG 570
            ||.:|.|.|:       ||.:..:..|.|||             :.:....|.|:.|.     :|
Mouse   298 VARHKFYRLNQCSLQTQAATLNSVRRGSSSR-------------MSLPKPQPYAMPPPPQLHYNG 349

  Fly   571 VFSVKLLRAGKCGLGLSVSGSSHGGLVISDVKMGSPAHR-----------SGSLRSGDILLAVDQ 624
            .::...             .||...:.:.: |.|...|.           ||.:|:|.:..|   
Mouse   350 HYTEPF-------------ASSQDNIFVPN-KNGFYCHSQTSLDRTQIDLSGRIRNGSVYSA--- 397

  Fly   625 HPVQHFN-VDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMG 688
            |.....| :...|:....|.|||.:.||        ::.||::|                     
Mouse   398 HSTNSLNTLQPYLQPSPMSSNPSITGSD--------VMRPDYIP--------------------- 433

  Fly   689 VSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRV-----PSMDDASLQSVQLRSGSGSNGG 748
               |..|    ||.:.          .|..|.|||..|     ..|..|...|..||:   .|.|
Mouse   434 ---SHRH----SALIP----------PSYRPTPDYETVMKQLNRGMVHADRHSHSLRN---LNIG 478

  Fly   749 NQAANSWSTGVNSRSYVAPP---NTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMEN 810
                       :|.:|..|.   .:|....|.|.....|...|| :.|| |:....:..|.|.|.
Mouse   479 -----------SSYAYSRPDALVYSQPEIREHPHLTSPQSAHYP-FNLN-YSFHSQSPYPYPAER 530

  Fly   811 KVYGSAASSSSKSSGSSLHQIIFTVRLE----PKGGLLGITL-------------AGSEDITKSI 858
            :....|.|...          :..|:|:    |...::...:             ..:.|:::.:
Mouse   531 RPVVGAVSVPE----------LTNVQLQAQDYPAPNIMRTQVYRPPPPYPYPRPANSTPDLSRHL 585

  Fly   859 TISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQ-----GMPLSHATSLLQNLGDLVDLKILRSHDL 918
            .||......|..:   :|          ||||     .:|::|:   ||.:.:            
Mouse   586 YISSSNPDLITRR---VH----------HSVQTFQEDSLPVAHS---LQEVSE------------ 622

  Fly   919 ANGSHLPQTQAIYAKVQRR------------------------------PRSPSANTEAS----- 948
                  |.|.|.:|.:|:|                              ||:.||.:::|     
Mouse   623 ------PLTAARHAHLQKRNSIEIAGLTHGFEGLRLKERTVSASAADVAPRTFSAGSQSSVFSDK 681

  Fly   949 -KESGSGNANGGGAVNGNSGSGKPRVFHVTLYKDKVYDD 986
             |:.|:....||...:..|.|....:.|.:...:.:.:|
Mouse   682 MKQEGTEEQEGGRYSHKKSLSDATMLIHSSEEDEDLEED 720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492
PDZ 496..>521 CDD:294084 2/2 (100%)
PDZ_signaling 571..658 CDD:238492 19/98 (19%)
PDZ_signaling 832..913 CDD:238492 16/102 (16%)
PDZ_signaling 973..1055 CDD:238492 2/14 (14%)
Ptpn21NP_001139671.1 B41 24..222 CDD:214604
FERM_N 27..90 CDD:286467
FERM_M 109..220 CDD:278785
FERM_C_PTPN14_PTPN21 217..307 CDD:270009 4/8 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 668..703 8/34 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 789..825
PTPc 898..1168 CDD:214550
PTPc 925..1168 CDD:238006
Substrate binding. /evidence=ECO:0000250 1110..1116
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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