DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and GRIP1

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_016874587.1 Gene:GRIP1 / 23426 HGNCID:18708 Length:1188 Species:Homo sapiens


Alignment Length:1288 Identity:334/1288 - (25%)
Similarity:479/1288 - (37%) Gaps:526/1288 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PTDTALAPMLSVDRAMSPAQSEDS---GLAPERGTTYATITLPRNALHLAITFAERNDLSYPPVV 108
            |.|.|||    |.|...|.:.:.|   .|..:.|||            |.:|.:...|....|.|
Human   107 PPDGALA----VRRQSIPEEFKGSTVVELMKKEGTT------------LGLTVSGGIDKDGKPRV 155

  Fly   109 GSLNPVGHAA--DFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVS 171
            .:|...|.||  |.|..||.:..::||:.....:.:::::|...|.   ..::|:||.||..:|.
Human   156 SNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGE---RVVLEVEYELPPVSVQ 217

  Fly   172 QNSLCVTSKLAQITVERESGCLGLTLRGGA------DYPLIVTHVRPHGPVYKTGRIKPGDRLLR 230
            .:|  |..:..::|:.:|....|..:||||      ..|:::|.|||.||..:.|.||||||||.
Human   218 GSS--VIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLS 280

  Fly   231 VDNVSLIGKTLAEAQQIIK-CGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLV 294
            ||.:.|:|.|.|||..|:| ||...:    |.|||||||:.||..:.||||:|:.:.....||:.
Human   281 VDGIRLLGTTHAEAMSILKQCGQEAA----LLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVA 341

  Fly   295 L-----CNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTM 354
            |     ||....|                       |..|..||||||||||.|||.:||||.|.
Human   342 LTTSMCCNKQVIV-----------------------IDKIKSASIADRCGALHVGDHILSIDGTS 383

  Fly   355 IEHTAFSPDEVMTILDTSTGRGYTQMQIMPAH--ALARRG------------------------- 392
            :|:...:  |....|..:|.:  .:::|:|.|  .||.:|                         
Human   384 MEYCTLA--EATQFLANTTDQ--VKLEILPHHQTRLALKGPDHVKIQRSDRQLTWDSWASNHSSL 444

  Fly   393 HT---------------TLGSPK----------------------YSFS-----TLESRKSSTAG 415
            ||               .|..||                      ||.|     ||.....||:.
Human   445 HTNHHYNTYHPDHCRVPALTFPKAPPPNSPPALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSP 509

  Fly   416 R---QRQRFAR---KSSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLL--D 472
            |   .|:|..:   ||||.|                     .||::|:...:...|:..|:|  |
Human   510 RGTMMRRRLKKKDFKSSLSL---------------------ASSTVGLAGQVVHTETTEVVLTAD 553

  Fly   473 CSHGAGIILSETVSGSGG-SGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAA--AMRQL 534
            ...|.||.|..:|..:.. |....|:.|..||.|:|.|.:|.|||::|||.:.:.|:.  ...||
Human   554 PVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQL 618

  Fly   535 LEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSH----GG 595
            |...|..:..:         ||||||:.::|:|:||.|.|||.:.....||:::|..|.    ..
Human   619 LRDSSITSKVT---------LEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDP 674

  Fly   596 LVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRI 660
            |||||:|.||.|||:|:|..||.|||:|...:.:.:::..::                       
Human   675 LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQ----------------------- 716

  Fly   661 VLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFR 725
                       |...|                                .|.|.||.|..:     
Human   717 -----------ILQQC--------------------------------EDLVKLKIRKDE----- 733

  Fly   726 VPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPG 790
                                                                 :..||||     
Human   734 -----------------------------------------------------DNSDEQE----- 740

  Fly   791 YELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDIT 855
                                            |||:    ||:||.|:..||.||||::|:|:..
Human   741 --------------------------------SSGA----IIYTVELKRYGGPLGITISGTEEPF 769

  Fly   856 KSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLAN 920
            ..|.||.|.:||:|.:.|.||:||::|||:..|::|.|||.|..|||..|:.|.|||.:..|..:
Human   770 DPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQS 834

  Fly   921 ---------GSHL---------------------------------------------------- 924
                     .|||                                                    
Human   835 ASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTS 899

  Fly   925 ---------------PQTQAIYAKVQRRPRS-------------------------PSANTEASK 949
                           |:.:...:.| .:|||                         .||.||..:
Human   900 FQASGYNFNTYDWRSPKQRGSLSPV-TKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEE 963

  Fly   950 --------------ESG-----SGNANGGGAVNGNSGSGKPR----------------------- 972
                          :||     ......|..::.|..:..||                       
Human   964 NFWSQALEDLETCGQSGILRELEATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTT 1028

  Fly   973 ---------------------------------VFHVTLYKDKVYDDYGFSVSDGLYERGVFINR 1004
                                             :..||||||...:|:||||:|||.|:||::..
Human  1029 RSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKN 1093

  Fly  1005 IRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQRS 1057
            ||..||.|:.| |||:||::|||.::|:||||||.|||||.:|:|:::::.|:
Human  1094 IRPAGPGDLGG-LKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRN 1145

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 15/66 (23%)
PDZ_signaling 183..254 CDD:238492 35/77 (45%)
PDZ_signaling 278..375 CDD:238492 34/101 (34%)
PDZ 496..>521 CDD:294084 12/24 (50%)
PDZ_signaling 571..658 CDD:238492 27/90 (30%)
PDZ_signaling 832..913 CDD:238492 40/80 (50%)
PDZ_signaling 973..1055 CDD:238492 45/81 (56%)
GRIP1XP_016874587.1 PDZ_signaling 128..208 CDD:238492 22/94 (23%)
PDZ_signaling 227..310 CDD:238492 36/86 (42%)
PDZ_signaling 325..408 CDD:238492 34/109 (31%)
PDZ_signaling 545..633 CDD:238492 30/96 (31%)
PDZ_signaling 646..730 CDD:238492 33/149 (22%)
PDZ_signaling 746..827 CDD:238492 40/80 (50%)
PDZ_signaling 1062..1142 CDD:238492 45/80 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 103 1.000 Domainoid score I6778
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 378 1.000 Inparanoid score I2085
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46788
OrthoDB 1 1.010 - - D42090at33208
OrthoFinder 1 1.000 - - FOG0003379
OrthoInspector 1 1.000 - - otm42044
orthoMCL 1 0.900 - - OOG6_103747
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2278
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.830

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