DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and LNX2

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_699202.1 Gene:LNX2 / 222484 HGNCID:20421 Length:690 Species:Homo sapiens


Alignment Length:677 Identity:141/677 - (20%)
Similarity:243/677 - (35%) Gaps:229/677 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 GTTYATITLPRNALHLAITFAERNDLSYPPVV---GSLNPVGHAADFLAPG----DRLHQIDGIS 134
            |.::..:.|.|.  ..:.|.||..:.:.|.::   |:|:|   .||.|..|    :|......:|
Human   139 GASHRRVALERR--KTSRTQAEIENENGPTLLDPAGTLSP---EADCLGTGAVPVERHLTSASLS 198

  Fly   135 T----IGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGC--L 193
            |    .||.|.....   :.|:|.    .:...||||           .::..|.:.|.:..  |
Human   199 TWSEEPGLDNPAFEE---SAGADT----TQQPLSLPE-----------GEITTIEIHRSNPYIQL 245

  Fly   194 GLTLRGGADYPLI---VTHVRPHGPVYKTGRIKPGDRLLRVD--NVSLIGKTLAEAQQIIKCGGH 253
            |:::.||.:.|||   :..|...|.:.:.||:..||::|:|:  |:|.:....|.|.....|.  
Human   246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCN-- 308

  Fly   254 VSGYTNLTIEYDVSVVQSVEF---------SMGPL--LIEI---ERPMNDKLGLVLCNYTAAVPA 304
                   |:.  ::|::...|         |..|.  :.::   :|...::||:.|...|     
Human   309 -------TLH--LTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRT----- 359

  Fly   305 SGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTIL 369
                           :..||||..:|...:|.:.|.||..|:||:|:                  
Human   360 ---------------DEPGVFILDLLEGGLAAQDGRLSSNDRVLAIN------------------ 391

  Fly   370 DTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPAC 434
                                  ||..    ||....|.::....:|       .:.:|.:..|..
Human   392 ----------------------GHDL----KYGTPELAAQIIQASG-------ERVNLTIARPGK 423

  Fly   435 GTPGSTGGSMGTGGIHGSSS-----------------LGMGLGLCRAESFPVLLDCSHGAGIILS 482
            ..||:|   :...|.|.|||                 |...: .|:.:...|..:.....|:   
Human   424 PQPGNT---IREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCV-TCQEKHITVKKEPHESLGM--- 481

  Fly   483 ETVSGSGGSGA----VAIAQIVPDSVADRSGCIQAGDRIVAIN-----KMYSLDAAAMRQLLEGG 538
             ||:|..||.:    :.:..:.|.....|.|.|:.||.::.||     .:...:|.||.:     
Human   482 -TVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK----- 540

  Fly   539 SSRNGASNGTPA---NWLELEI------------------EFD---MPDAV----VPAS--GVFS 573
                 ||..:||   ..||::|                  |:|   .|..|    :|::  ....
Human   541 -----ASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHD 600

  Fly   574 VKLLRAGKCGLGLSVSGS-----SHGGLVISDVKMGSPAHRSGSLRSGDILLAVD---QHPVQHF 630
            :.|.|:.....|.|:.|.     ::....|..:.:|:||:..|.|:.||:::||:   ...:.|.
Human   601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHS 665

  Fly   631 NVDALLKEEGRSQNPSHSSSDFTTLTI 657
            .:..:|||:...          .|||:
Human   666 ALVPMLKEQRNK----------VTLTV 682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 19/75 (25%)
PDZ_signaling 183..254 CDD:238492 22/77 (29%)
PDZ_signaling 278..375 CDD:238492 19/101 (19%)
PDZ 496..>521 CDD:294084 6/24 (25%)
PDZ_signaling 571..658 CDD:238492 22/95 (23%)
PDZ_signaling 832..913 CDD:238492
PDZ_signaling 973..1055 CDD:238492
LNX2NP_699202.1 mRING-HC-C3HC3D_LNX2 45..89 CDD:319694
modified RING-HC finger (C3HC3D-type) 50..87 CDD:319694
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..224 7/32 (22%)
NPXY motif 208..211 1/2 (50%)
PDZ 230..316 CDD:214570 24/96 (25%)
PDZ 336..422 CDD:214570 25/156 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..455 9/39 (23%)
PDZ_signaling 466..542 CDD:238492 18/89 (20%)
PDZ_signaling 599..683 CDD:238492 22/94 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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