DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and Ptpn4

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_064317.2 Gene:Ptpn4 / 19258 MGIID:1099792 Length:926 Species:Mus musculus


Alignment Length:265 Identity:56/265 - (21%)
Similarity:97/265 - (36%) Gaps:79/265 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   728 SMDDASLQSVQLRSGSGS-NGGNQAANSWSTGVN----------------SRSYV---APPNTQS 772
            |.|....||:..||..|: |..|.:....:|.|.                |..:|   :|.:||:
Mouse   379 SDDRLETQSLPSRSPPGTPNHRNSSFTQEATRVRPSSVGHLVDHVVHMSPSEDFVSQRSPSSTQA 443

  Fly   773 LTTEL---PEEEDEQEQMYPGYELNRYASVDCTALPPPME-----NKVYGS-------------- 815
            .:..|   |.:|..::...|             ||||...     |:::.|              
Mouse   444 NSIVLESSPSQETPEDGQPP-------------ALPPKQSKKNSWNQIHFSNSQQDLVTHTNESF 495

  Fly   816 -AASSSSKS--SGSSLHQIIFTVRLEP-KGGLLGITLAGSEDITKSITISGLVEGGIAHK-NGQI 875
             ..||..||  :|...|..:..::::| :.|..|..:.|..|....:.:|.:..|..|.. ..::
Mouse   496 DVPSSPEKSTPNGGIPHDNLVLIKMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRL 560

  Fly   876 HVGDQLLAID-----EHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLPQTQAIYAKVQ 935
            :.|||::.|:     ||:...:.|....|..::.|:||              .|.:..|:|..|:
Mouse   561 NEGDQVVLINGRDIAEHTHDQVVLFIKASCEKHSGELV--------------LLVRPNAVYDVVE 611

  Fly   936 RRPRS 940
            .:..|
Mouse   612 EKLES 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492
PDZ 496..>521 CDD:294084
PDZ_signaling 571..658 CDD:238492
PDZ_signaling 832..913 CDD:238492 19/87 (22%)
PDZ_signaling 973..1055 CDD:238492
Ptpn4NP_064317.2 B41 30..222 CDD:214604
FERM_N 33..97 CDD:286467
FERM_M 115..222 CDD:278785
FERM_C_PTPN4_PTPN3_like 216..310 CDD:270010
FA 325..365 CDD:285894
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 379..412 10/32 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..474 13/57 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 492..511 5/18 (28%)
PDZ_signaling 515..602 CDD:238492 20/100 (20%)
PTPc 657..910 CDD:214550
PTPc 682..909 CDD:238006
Substrate binding. /evidence=ECO:0000250 852..858
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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