DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and Ptpn14

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_033002.2 Gene:Ptpn14 / 19250 MGIID:102467 Length:1189 Species:Mus musculus


Alignment Length:434 Identity:82/434 - (18%)
Similarity:141/434 - (32%) Gaps:128/434 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   525 SLDAAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASG----VFSVKLLRAGKCGLG 585
            :::.||:.:|.:..:..:.|.:|.    |..|.|....:.|....|    :|.||........||
Mouse   173 AMEEAALEELTQKVAQEHKAHSGI----LPAEAELMYINEVERLDGFGQEIFPVKDSHGNSVHLG 233

  Fly   586 LSVSG------SSHGGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQN 644
            :...|      .....::.....:||..|...::    :|..:|:.....|:.|.:       :|
Mouse   234 IFFMGIFVRNRVGRQAVIYRWNDIGSVTHSKAAI----LLELIDKEETALFHTDDI-------EN 287

  Fly   645 PSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYA 709
            ..:.|..||                                       |.|..|....:      
Mouse   288 AKYISRLFT---------------------------------------TRHKFYKQNKI------ 307

  Fly   710 DCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLT 774
             |.. :|.:| |...|.|:...:||...|                        .|:.||.....:
Mouse   308 -CTE-QSNSP-PPIRRQPTWSRSSLPRQQ------------------------PYILPPMHVQCS 345

  Fly   775 TELPEEEDEQEQMYPGYELNRYA----SVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTV 835
            ....|....|:.::||.|...|.    |:|...|...:.|   ||..|..|.:|.|.....|   
Mouse   346 EHYSETHTSQDSIFPGNEEALYCRSHNSLDLNYLNGTVTN---GSVCSVHSVNSLSCSQSFI--- 404

  Fly   836 RLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGM---PLSHA 897
            :..|...  .:::.|| ||.::..|.       :|::..|.|.......|..:|...   .|.||
Mouse   405 QASPVSS--NLSIPGS-DIMRADYIP-------SHRHSTIIVPSYRPTPDYETVMRQMKRGLMHA 459

  Fly   898 TSLLQNLGDLVDLKILRSHDLANGSHLPQTQAIYAKVQRRPRSP 941
            .|..::|.   :|.|:.:|     ::....:.:|::.:.|.|.|
Mouse   460 DSQSRSLR---NLNIINTH-----AYNQPEELVYSQPEMRERHP 495

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492
PDZ 496..>521 CDD:294084
PDZ_signaling 571..658 CDD:238492 17/92 (18%)
PDZ_signaling 832..913 CDD:238492 18/83 (22%)
PDZ_signaling 973..1055 CDD:238492
Ptpn14NP_033002.2 B41 24..220 CDD:214604 10/50 (20%)
FERM_C_PTPN14_PTPN21 215..305 CDD:270009 20/139 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..775
PTPc-N14 898..1184 CDD:350447
Substrate binding. /evidence=ECO:0000250 1123..1129
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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