DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and Ptpn13

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_035334.2 Gene:Ptpn13 / 19249 MGIID:103293 Length:2451 Species:Mus musculus


Alignment Length:1173 Identity:249/1173 - (21%)
Similarity:406/1173 - (34%) Gaps:363/1173 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 RAMSPAQSE--DSGLAPERGTTYATITLPRNALHLAITFAERNDLSYPPVVGS-LNPVGHA-ADF 120
            |.||.:..:  .:.|.|.|........||:       .|||        :||. |.|:..: .:.
Mouse   957 RGMSKSYHDLSQASLCPHRKQVINMEALPQ-------AFAE--------LVGKPLYPMARSDTES 1006

  Fly   121 LAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSL---------- 175
            ||...:|.....::::..|.::..:...:...|...|.| :..|||....|.:.:          
Mouse  1007 LAGLPKLDNSKSVASLNRSPERRNHESDSSTEDPGQAYV-VGMSLPSSGKSSSQVPFKDNDTLHK 1070

  Fly   176 ---CVTSKLAQITV-----ERESGCLGLTLRGG-----ADYPLIVTHVRPHGPVYKTGRIKPGDR 227
               .|:|...:||:     :.:.| ||..:.||     .|..:.::.|.|.||....|.:|||||
Mouse  1071 RWSIVSSPEREITLVNLKKDPKHG-LGFQIIGGEKMGRLDLGVFISAVTPGGPADLDGCLKPGDR 1134

  Fly   228 LLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQS-------------VEFSMGPL 279
            |:.|::|||.|.:...|..|::           ....||::|.|             |.|:.|  
Mouse  1135 LISVNSVSLEGVSHHAAVDILQ-----------NAPEDVTLVISQPKEKPSKVPSTPVHFANG-- 1186

  Fly   280 LIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVG 344
                           :.:||.........:..||..:......    ...:|.|.....|.|..|
Mouse  1187 ---------------MKSYTKKPAYMQDSAMDPSEDQPWPRGT----LRHIPESPFGLSGGLREG 1232

  Fly   345 DQVLSIDDTMIEHTAFSPDEVMTILDTSTG-RGYTQMQIMPAHALARRGHTTLGSPKYSFSTLES 408
            .  ||..|:..|..:.|..:|.....:..| ||:.:    |.|:          ||..|.:|..:
Mouse  1233 S--LSSQDSRTESASLSQSQVNGFFASHLGDRGWQE----PQHS----------SPSPSVTTKVN 1281

  Fly   409 RKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHGSSSL--GMGLGLCRAESFPV-- 469
            .|:.:...:.:...|..|..:|:..|........:..:...|.:|..  ...|......|||.  
Mouse  1282 EKTFSDSNRSKAKRRGISDLIEHLDCADSDKDDSTYTSSQDHQTSKQEPSSSLSTSNKTSFPTSS 1346

  Fly   470 -------------LLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAIN 521
                         |.......||.::..|:.|...|.:.:..|:|...|:..|.|..|||::|:|
Mouse  1347 ASPPKPGDTFEVELAKTDGSLGISVTGGVNTSVRHGGIYVKAIIPKGAAESDGRIHKGDRVLAVN 1411

  Fly   522 KMYSLDAAAMRQ--------------LLEGG---SSRNGASNGTPANWLELEIEFDMPDAV---- 565
            .: ||:.|..:|              |||.|   :||.....|..:...:.:.:...|:.|    
Mouse  1412 GV-SLEGATHKQAVETLRNTGQVVHLLLEKGQVPTSRERDPAGPQSPPPDQDAQRQAPEKVAKQT 1475

  Fly   566 --------VPASGVFSVKLLRAGKCGLGLSVSGSSH------GGLVISDVKM--GSPAHRSGSLR 614
                    |.....|.|||.: ...|||.|.|...:      .|.::...|:  |.||..||.:.
Mouse  1476 PHVKDYSFVTEDNTFEVKLFK-NSSGLGFSFSREDNLIPEQINGSIVRVKKLFPGQPAAESGKID 1539

  Fly   615 SGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRI-------VLPD----FLPM 668
            .||::|.|:..|:           :|.||....|:...|...:..:       |||:    ||  
Mouse  1540 VGDVILKVNGAPL-----------KGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEIDTTFL-- 1591

  Fly   669 SSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDAS 733
             :|:||  ||:..     :..|..|..   .|:.|..|..:|...:..:|  .::.|.||    .
Mouse  1592 -NPLYS--PANSF-----LNSSKETSQ---PSSSVEQGASSDDNGVSGKT--KNHCRAPS----R 1639

  Fly   734 LQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTT---ELPEEEDEQ-------EQMY 788
            .:|....|.||.:.            :.|:....||...:..   |.|..::|.       .:..
Mouse  1640 RESYSDHSESGEDD------------SVRAPAKMPNVTRVAAFPHEAPRSQEESICAMFYLPRKI 1692

  Fly   789 PGYELNRYASVDCTALPPPME-------------------NKVYGSAASSSSKSS---------G 825
            || :|...:|     .|||::                   .|.:...||..||..         |
Mouse  1693 PG-KLESESS-----HPPPLDVSPGQTCQPPAECAPSDATGKHFTHLASQLSKEENITTLKNDLG 1751

  Fly   826 SSLH------QIIFTVRLEPKGGLLGITLA-GSEDITKSITISGLVEGGIAHKNGQIHVGDQLLA 883
            :.|.      :::.|:....||. ||.|:. ||:.|  ...:..:::.. |..:|::..||:|:.
Mouse  1752 NHLEDSELEVELLITLVKSEKGS-LGFTVTKGSQSI--GCYVHDVIQDP-AKGDGRLKAGDRLIK 1812

  Fly   884 IDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLPQT-QAIYAKVQRRPRSPSANTEA 947
            :::..|..|..:.|.:||:                    ..|:| :.:..::...||.|      
Mouse  1813 VNDTDVTNMTHTDAVNLLR--------------------AAPKTVRLVLGRILELPRMP------ 1851

  Fly   948 SKESGSGNANGGGAVNGNSGSGKPRVF-H------VTLYKDKVYDDYGFSVSDGLYERG-----V 1000
                                     || |      ||.:.:::    |||:|.|   :|     |
Mouse  1852 -------------------------VFPHLLPDITVTCHGEEL----GFSLSGG---QGSPHGVV 1884

  Fly  1001 FINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDF----------------------DCCLTVPLI 1043
            :|:.|.....|.:.|.|:..|.|..||.:.||..                      |.|..||..
Mouse  1885 YISDINPRSAAAVDGSLQLLDIIHYVNGVSTQGMTLEDANRALDLSLPSVVLKVTRDGCPVVPTT 1949

  Fly  1044 AAA 1046
            .||
Mouse  1950 RAA 1952

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 13/66 (20%)
PDZ_signaling 183..254 CDD:238492 26/80 (33%)
PDZ_signaling 278..375 CDD:238492 16/97 (16%)
PDZ 496..>521 CDD:294084 9/24 (38%)
PDZ_signaling 571..658 CDD:238492 26/94 (28%)
PDZ_signaling 832..913 CDD:238492 19/81 (23%)
PDZ_signaling 973..1055 CDD:238492 29/108 (27%)
Ptpn13NP_035334.2 KIND 3..190 CDD:214801
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..227
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..285
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..457
B41 566..774 CDD:214604
FERM_N 569..631 CDD:286467
FERM_M 661..774 CDD:278785
PH-like 770..870 CDD:302622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..966 3/8 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1063 11/56 (20%)
PDZ_signaling 1082..1166 CDD:238492 28/95 (29%)
PTN13_u3 1168..1356 CDD:293207 38/224 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1199..1356 33/176 (19%)
PDZ_signaling 1355..1439 CDD:238492 21/84 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1441..1478 6/36 (17%)
PDZ 1488..1578 CDD:214570 26/101 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1602..1662 15/80 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1695..1726 5/35 (14%)
PDZ_signaling 1762..1841 CDD:238492 21/102 (21%)
PDZ 1859..1942 CDD:214570 20/89 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2024
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2051..2139
Neuromodulin 2067..2207 CDD:284117
PTPc 2181..2433 CDD:214550
PTPc 2207..2433 CDD:238006
Substrate binding. /evidence=ECO:0000250 2375..2381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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