DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip and T19B10.5

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_505852.3	Gene:	T19B10.5 / 179553	WormBaseID:	WBGene00011833	Length:	596	Species:	Caenorhabditis elegans

Alignment Length:	363	Identity:	76/363 - (20%)
Similarity:	127/363 - (34%)	Gaps:	94/363 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   504 VADRSGCIQAGDRIVAIN--KMYSLDAAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVV 566
            |.|: ||    |...:||  ||..:|:..:::.:|...::...|           :||     :.
Worm    78 VEDK-GC----DAPKSINKDKMTMIDSFKLKRKMEDSGTQKAYS-----------MEF-----LN 121

  Fly   567 PASGVFSVKLLRAGKCGLGLSVSGSSHGGLVISDVKMGSPAHRSGSLRSGDIL--LAVDQHPVQH 629
            ...|...|:|......|||.::.|:.:.|:.:.::.....|.:.|::..||.:  |.::...:.:
Worm   122 EVEGKVGVQLRGVDIGGLGFNIQGNMNEGIFVKEIISKGIAEQCGNILVGDKIKSLTINFENMVY 186

  Fly   630 FNVDALLK-----------EEGRSQNPSHSSSD----------FTTLTIKRIVLPDFLPMSSPI- 672
            .:...||.           |...|.:.|.|.||          |.:.|:..:.......:|:|.
Worm   187 EDAVTLLSYSSPYKVKLELERKLSDSASVSDSDDDKEMRYHPLFRSNTLTHVHFNPLGTISTPTS 251

  Fly   673 YSNCPASGINLGMGMGVSTSTD----HDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDAS 733
            .:..|..          .||||    |.|.....:.......|....|:....|..|:.|.|..|
Worm   252 IATTPQR----------CTSTDSKQKHALPPQREIIEPDSTTCADDNSQARDADNSRMDSSDYGS 306

  Fly   734 LQSVQLRSGSGSNGGNQAANSWSTGVNSRSYV-----------APPNTQSL--TTELPEEEDEQE 785
            ......|..:.|:|..:.       ::.|..|           .||..:.|  .||||.:..:..
Worm   307 DGISDCRESTASDGTQKT-------LSDRIEVTDIIFDKVKSPTPPPLRKLEQCTELPPKPRKMV 364

  Fly   786 QMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKS 823
            ...|. .:|:          ||...||  |.|:|..||
Worm   365 SRSPS-PVNK----------PPPSPKV--SRATSPKKS 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084
		PDZ_signaling	183..254	CDD:238492
		PDZ_signaling	278..375	CDD:238492
		PDZ	496..>521	CDD:294084	5/16 (31%)
		PDZ_signaling	571..658	CDD:238492	22/109 (20%)
		PDZ_signaling	832..913	CDD:238492
		PDZ_signaling	973..1055	CDD:238492
T19B10.5	NP_505852.3	PDZ	137..208	CDD:214570	13/70 (19%)
T19B10.5	NP_505852.3	PTZ00449	<340..483	CDD:185628	18/63 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900