DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and Mpdz

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_001292213.1 Gene:Mpdz / 17475 MGIID:1343489 Length:2069 Species:Mus musculus


Alignment Length:1351 Identity:280/1351 - (20%)
Similarity:450/1351 - (33%) Gaps:464/1351 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 PMLSVDRAMSPAQSEDSGLAPE----RGTTYATITLPRNALHLAITFAERNDL--SYPPVVG--- 109
            |:||.:...:....:::.|..:    .|..|..:     ..|:: .|:|.:.|  |....||   
Mouse   512 PLLSAELEEAEDVQQEAALLTKWQRIMGINYEIV-----VAHVS-KFSENSGLGISLEATVGHHF 570

  Fly   110 -----SLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVMN----------MLCAGGSDACPAIV 159
                 ...||||:.. |..||.|.:::||:.:|.::|.|:|          |:|...:....|:.
Mouse   571 IRSVLPEGPVGHSGK-LFSGDELLEVNGINLLGENHQDVVNILKELPIDVTMVCCRRTVPPIALS 634

  Fly   160 EIEY----------------------------SLPECTVSQNSLCVTSKLA-------QITVERE 189
            |::.                            .|....|.||:..:.:.||       .|.:|:.
Mouse   635 EMDSLDINDLELTEKPHIDLGEFIGSSETEDPMLAMSDVDQNAEEIQTPLAMWEAGGQSIELEKG 699

  Fly   190 SGCLGLTLRGGADYP---------LIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQ 245
            |..||.::   .||.         :::..:.|.|...|.||:.|||||:.|::::|...||.||.
Mouse   700 SRGLGFSI---LDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAV 761

  Fly   246 QIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLV-------LCNYTAAVP 303
            :.:|  |..||...:.:             ..||      |::.:.|.|       ||:..|...
Mouse   762 EALK--GAPSGMVRIGV-------------AKPL------PLSPEEGYVSAKEDAFLCSPHACKE 805

  Fly   304 ASGSGSS----------TPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSI-DDTMIEH 357
            :..|..:          ||.: |.|.||.  |.:...|    |.....|....:.|: |.|..:.
Mouse   806 SGLSDKALFRADLALIDTPDA-ESIAESR--FESQFSP----DNDSVYSTQASIFSLHDGTCSDG 863

  Fly   358 TAFSP-------------DEVMTILDTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESR 409
            ..:.|             .||:..|..|....|||..:...||         |||     ..:.|
Mouse   864 MNYGPSLPSSPPKDVTSSSEVVLGLHLSLEELYTQNLLQRQHA---------GSP-----PTDMR 914

  Fly   410 KSSTAGRQRQRFARKSSLPLE----NPACGTPGSTGGSMGTGGIH-----------------GSS 453
            .:.|:|.....:...:::..:    ||..........|:.|..:.                 .|.
Mouse   915 PAPTSGFPISDYTTTNAVEQKYECANPVAWPHSQLPSSLSTSELAPALPAVAQKYLTDQSSLASD 979

  Fly   454 SLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIV 518
            :..:.|.....|:|...:..:.|:. .|..|||.:.....|.:..|:......|.|.|..||.|:
Mouse   980 AESVNLQSMSQEAFERTVTIAKGSS-SLGMTVSANKDGLGVIVRSIIHGGAISRDGRIAVGDCIL 1043

  Fly   519 AINK-----MYSLDAAAM--RQLLEGGSSRNGASNG-----------TPANWL-ELEIEFDMPDA 564
            :||:     :.:..|.||  |..|.|...:..|:..           .||..| |..:.|.....
Mouse  1044 SINEESTISLTNAQARAMLRRHSLIGPDIKFSAAPADDRAPFYVITYVPAEHLEEFRVSFGQQAG 1108

  Fly   565 VVPASGVFS------------------------------------VKLLRAGKCGLGLSVSGS-- 591
            .:.|..:||                                    |:|.|.....||:|:.|.  
Mouse  1109 GIMALDIFSSYTGRDIPELPEREEGEGEESELQNAAYSSWSQPRRVELWREPSKSLGISIVGGRG 1173

  Fly   592 -----SHG----GLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSH 647
                 |:|    |:.|..|...|||.::|:|:.||.::.||...::..:.:..::...::.||  
Mouse  1174 MGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIIEVDGMDLRDASHEQAVEAIRKAGNP-- 1236

  Fly   648 SSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSS-AYVTAGKYADC 711
                 ....::.|:   ..|..||:                  .|..|.||.. ::.:...:||.
Mouse  1237 -----VVFMVQSII---NRPRKSPL------------------PSLPHSLYPKYSFSSTNPFADS 1275

  Fly   712 VSL---------KSRTPQPDYFRVP----------------------SMDD-------ASLQSVQ 738
            :.|         :|.|.:|....||                      |.|:       .|.:::|
Mouse  1276 LQLTTDQAPSQSESETEKPALCNVPPSSPSVFSEMGSDCAQPSATAVSEDEDKEDEFGYSWKNIQ 1340

  Fly   739 LRSGS------------GSNG------GNQAANSWS-----------TGVNSRSYVAP------- 767
            .|.||            |.:|      ||:.....|           .|.:.|..:|.       
Mouse  1341 ERYGSLTGQLHVIELEKGQSGLGLSLAGNKDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEING 1405

  Fly   768 --------PNTQSLTTELPEE--------EDEQEQM--YPGYELNRYASVDCTALPPPMENKVYG 814
                    .|..|:....|.:        .|...||  .||...:..:|..    ..|...:|..
Mouse  1406 QILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGIAADSPSSTS----DSPQNKEVEP 1466

  Fly   815 SAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGD 879
            .:.:|:|.:..|||.. ::.:.|....|.|||.:. .||....:.|..|.|.|.|.|:|::..||
Mouse  1467 CSTTSASAADLSSLTD-VYQLELPKDQGGLGIAIC-EEDTINGVMIESLTEHGGAAKDGRLKPGD 1529

  Fly   880 QLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILR---------------SHDLANGSHLP---- 925
            .:||:|:..|.|.|:....|||:.....|.|.:..               |.:..:.|..|    
Mouse  1530 HILAVDDEVVAGCPVEKFISLLKTAKATVKLTVRAENPACPAVPSSAVTVSGERKDNSQTPAVPA 1594

  Fly   926 ------------QTQAIYAKVQRR-PRSPSANT--EASK-ESGSGNANGGGA------------- 961
                        .|.|::|..... |..|...|  |.|| ::|.|.:..||:             
Mouse  1595 PDLEPIPSTSRSSTPAVFASDPATCPIIPGCETTIEISKGQTGLGLSIVGGSDTLLGAIIIHEVY 1659

  Fly   962 -------------------VNG------------NSGSGKPRVFHVTLYKDK-------VYDDY- 987
                               |||            |.....|:...:|||:|:       |.|.: 
Mouse  1660 EEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEDVCDTFT 1724

  Fly   988 -----------GFSVSDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVN 1027
                       |.|:.....:.|||::.|..||.||..|.|...|:|:.||
Mouse  1725 IELQKRPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVN 1775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 21/84 (25%)
PDZ_signaling 183..254 CDD:238492 25/79 (32%)
PDZ_signaling 278..375 CDD:238492 27/127 (21%)
PDZ 496..>521 CDD:294084 7/24 (29%)
PDZ_signaling 571..658 CDD:238492 25/133 (19%)
PDZ_signaling 832..913 CDD:238492 27/80 (34%)
PDZ_signaling 973..1055 CDD:238492 22/74 (30%)
MpdzNP_001292213.1 L27_2 6..63 CDD:117611
PDZ_signaling 140..222 CDD:238492
PDZ_signaling 256..335 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..372
PDZ 375..464 CDD:214570
PDZ_signaling 553..622 CDD:238492 19/69 (28%)
PDZ_signaling 694..777 CDD:238492 27/100 (27%)
PDZ_signaling 994..1064 CDD:238492 18/70 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1125..1144 0/18 (0%)
PDZ_signaling 1151..1242 CDD:238492 23/97 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1278..1313 6/34 (18%)
PDZ 1349..1434 CDD:214570 11/84 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1449..1473 4/27 (15%)
PDZ_signaling 1483..1563 CDD:238492 27/80 (34%)
MPDZ_u10 1564..1625 CDD:293272 8/60 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1571..1611 4/39 (10%)
PDZ 1626..1710 CDD:214570 16/83 (19%)
PDZ_signaling 1722..1802 CDD:238492 16/54 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1809..1848
PDZ_signaling 1859..1944 CDD:238492
PDZ_signaling 1985..2068 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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