DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and DLG4

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_011522001.1 Gene:DLG4 / 1742 HGNCID:2903 Length:797 Species:Homo sapiens


Alignment Length:1039 Identity:188/1039 - (18%)
Similarity:294/1039 - (28%) Gaps:444/1039 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 LWKSKKPIGGCVPGKSAALKQDQQQ--------QQQQQQESHNNSFNGHHHPPTDTALAPMLSVD 59
            ||....|:....|.....|..|..|        .:....||....:.....||.:          
Human    12 LWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDEDTPPLE---------- 66

  Fly    60 RAMSPAQSEDSGLAPERGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPG 124
              .|||...:...|||             .:|:    |||| ||:  :......||||  .|:|.
Human    67 --HSPAHLPNQVNAPE-------------LVHV----AERN-LSH--LEAGHGVVGHA--HLSPF 107

  Fly   125 DR-----LHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQI 184
            ..     :...|.:...|..|          |::.     |:||.                  :|
Human   108 KANSPPVIVNTDTLEAPGYVN----------GTEG-----EMEYE------------------EI 139

  Fly   185 TVERESGCLGLTLRGGADYP-------LIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLA 242
            |:||.:..||.::.||.|.|       :.:|.:.|.|...:.||::..|.:|.|:.|.:...|.:
Human   140 TLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHS 204

  Fly   243 EAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGS 307
            .|.:.:|..|.:.....:..:.....|..::...||          ..||..:        |.|.
Human   205 AAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGP----------KGLGFSI--------AGGV 251

  Fly   308 GSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTS 372
            |:      :.|.....:::..|:....|.:.|.|.:||::|:::...:|                
Human   252 GN------QHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE---------------- 294

  Fly   373 TGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTP 437
                    .:|...|:|...:|      |....|:..|.|.|                       
Human   295 --------DVMHEDAVAALKNT------YDVVYLKVAKPSNA----------------------- 322

  Fly   438 GSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPD 502
                                                      .||::.:             .||
Human   323 ------------------------------------------YLSDSYA-------------PPD 332

  Fly   503 SVADRSGCIQAGDRIVAINKMYSLDAAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVP 567
                             |...||       |.|:...| :.:..||           |.|.|:.|
Human   333 -----------------ITTSYS-------QHLDNEIS-HSSYLGT-----------DYPTAMTP 361

  Fly   568 AS------------GVFSVK------LLRAGKCGLGLSVSGSSHG-GLVISDVKMGSPAHRSGSL 613
            .|            |...:.      ::..|..|||.::.|...| |:.||.:..|.||..||.|
Human   362 TSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 426

  Fly   614 RSGDILLA---VDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSN 675
            |.||.:|:   ||.....|......||..|:            |:||    :..:.|..   ||.
Human   427 RKGDQILSVNGVDLRNASHEQAAIALKNAGQ------------TVTI----IAQYKPEE---YSR 472

  Fly   676 CPA-------SGINLGMGMGVS---TSTDHDLYSSAYVTAGKYADC------------------- 711
            ..|       ..:|..:|.|.:   ::.....|..|.....|..||                   
Human   473 FEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVID 537

  Fly   712 -----------VSLKSRTPQ----PDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNS 761
                       |...|.|..    |...||...:.:.|::....|.|||.|...:..|:.|....
Human   538 ASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQM 602

  Fly   762 RSYVAPP----------NTQSLTTELP------------------------------EEEDEQEQ 786
            ..:.|.|          ....|.:|.|                              |:.::..|
Human   603 EVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQ 667

  Fly   787 MYPGYELNRYASVDCTALPPPMENKVYGS-------------------AASSSSKSSGSSLHQII 832
            .:...|..:|.|            .:||:                   :|::..:...:.||.|.
Human   668 AHKFIEAGQYNS------------HLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIA 720

  Fly   833 FTVRLEPKGGLLGITLAGSEDITKSIT---------------------ISGLVEGG----IAHK 871
            ..:|  |:      :|....:|.|.||                     .|.:|||.    |.||
Human   721 IFIR--PR------SLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHK 776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 16/69 (23%)
PDZ_signaling 183..254 CDD:238492 23/77 (30%)
PDZ_signaling 278..375 CDD:238492 15/96 (16%)
PDZ 496..>521 CDD:294084 2/24 (8%)
PDZ_signaling 571..658 CDD:238492 27/96 (28%)
PDZ_signaling 832..913 CDD:238492 14/65 (22%)
PDZ_signaling 973..1055 CDD:238492
DLG4XP_011522001.1 L27 <26..49 CDD:413432 3/22 (14%)
MAGUK_N_PEST 54..137 CDD:402306 27/131 (21%)
PDZ 138..222 CDD:395476 23/83 (28%)
PDZ 233..317 CDD:395476 22/137 (16%)
PDZ_assoc 318..385 CDD:402299 21/180 (12%)
PDZ 383..467 CDD:214570 28/99 (28%)
SH3_DLG4 503..568 CDD:212963 10/64 (16%)
Guanylate_kin 606..784 CDD:395500 30/191 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23119
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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