DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and DLG1

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_004078.2 Gene:DLG1 / 1739 HGNCID:2900 Length:926 Species:Homo sapiens


Alignment Length:873 Identity:164/873 - (18%)
Similarity:276/873 - (31%) Gaps:342/873 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 NSFNGHHH-------------PPTDTALAPMLSVDRAMSPAQSEDSGLAPERGTTYATITLPRNA 89
            :.|..|.|             ||| ..:.|:|.|     ||::              |:.||   
Human   149 HGFVSHSHISPIKPTEAVLPSPPT-VPVIPVLPV-----PAEN--------------TVILP--- 190

  Fly    90 LHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDA 154
                 |..:.|.   |||:                        ::|..|.....:|     |:||
Human   191 -----TIPQANP---PPVL------------------------VNTDSLETPTYVN-----GTDA 218

  Fly   155 CPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGADYP-------LIVTHVRP 212
                 :.||.                  :||:||.:..||.::.||.|.|       :.:|.:..
Human   219 -----DYEYE------------------EITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIIT 260

  Fly   213 HGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMG 277
            .|...:.||::..|.:|||:.|.:...|.::|.:.:|..|              |:|:       
Human   261 GGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG--------------SIVR------- 304

  Fly   278 PLLIEIERPMNDK------------LGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASIL 330
             |.::..:|:::|            ||..:        |.|.|:      :.|.....:::..|:
Human   305 -LYVKRRKPVSEKIMEIKLIKGPKGLGFSI--------AGGVGN------QHIPGDNSIYVTKII 354

  Fly   331 PASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARRGHTT 395
            ....|.:.|.|.:||::|::::..:|..  :.:|.:|.|..::...|.:: ..|.......|:  
Human   355 EGGAAHKDGKLQIGDKLLAVNNVCLEEV--THEEAVTALKNTSDFVYLKV-AKPTSMYMNDGY-- 414

  Fly   396 LGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMGLG 460
             ..|..:.|                    ||.|::|                .:..||.||.   
Human   415 -APPDITNS--------------------SSQPVDN----------------HVSPSSFLGQ--- 439

  Fly   461 LCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYS 525
                                                   .|.|.|          |...::|...
Human   440 ---------------------------------------TPASPA----------RYSPVSKAVL 455

  Fly   526 LDAAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSG 590
            .|....|:                            |..||          |..|..|||.::.|
Human   456 GDDEITRE----------------------------PRKVV----------LHRGSTGLGFNIVG 482

  Fly   591 SSHG-GLVISDVKMGSPAHRSGSLRSGDILL---AVDQHPVQHFNVDALLKEEGRS--------- 642
            ...| |:.||.:..|.||..||.||.||.::   :||.....|....|.||..|::         
Human   483 GEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547

  Fly   643 -----------------QNPSHSSSDFTTLTIKR--IVLPDFLPMSSPIYSNCPASGINLGMG-- 686
                             .|.|.||...:..|.::  :.:...........|..|:.|:|...|  
Human   548 EEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDI 612

  Fly   687 MGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQA 751
            :.|..::|.:.:.:..||....:|.|.:     .|...||...:.|.|::|:..|.:...|  |:
Human   613 LHVINASDDEWWQARQVTPDGESDEVGV-----IPSKRRVEKKERARLKTVKFNSKTRDKG--QS 670

  Fly   752 AN-SWSTGVNSRSYVAPPN-----------TQSLTTELPEEEDE---QEQMYPGYELNRYASVDC 801
            .| .....:.||.:....|           .|.:|:...:.|..   ||:....||......|:.
Human   671 FNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNY 735

  Fly   802 T---ALPPPMENKVYGSAASSSSKSSGS 826
            |   .:..||::::.....|......||
Human   736 TRPVIILGPMKDRINDDLISEFPDKFGS 763

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 11/64 (17%)
PDZ_signaling 183..254 CDD:238492 23/77 (30%)
PDZ_signaling 278..375 CDD:238492 20/108 (19%)
PDZ 496..>521 CDD:294084 4/24 (17%)
PDZ_signaling 571..658 CDD:238492 31/116 (27%)
PDZ_signaling 832..913 CDD:238492
PDZ_signaling 973..1055 CDD:238492
DLG1NP_004078.2 L27_1 2..62 CDD:370268
MAGUK_N_PEST 106..223 CDD:371162 26/138 (19%)
PDZ_signaling 224..308 CDD:238492 26/105 (25%)
PDZ_signaling 317..403 CDD:238492 18/102 (18%)
PDZ_assoc 404..465 CDD:371157 19/179 (11%)
PDZ 463..547 CDD:214570 29/121 (24%)
SH3_DLG1 582..648 CDD:212964 13/70 (19%)
Guanylate_kin 735..913 CDD:366206 6/29 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23119
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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