DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Grip2

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_612544.2 Gene:Grip2 / 171571 RGDID:621668 Length:1043 Species:Rattus norvegicus


Alignment Length:1225 Identity:320/1225 - (26%)
Similarity:460/1225 - (37%) Gaps:487/1225 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 PE--RGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAA--DFLAPGDRLHQIDGIS 134
            ||  ||.|...: :.|....|.:|.:...|....|.|.:|.|.|.||  |.|..||.:..::||.
  Rat    45 PEEFRGITMVEL-IKREGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNVGDYIRSVNGIR 108

  Fly   135 TIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRG 199
            ...|.:.:::.:|...|.   ..::|:||.||. ...:|:..:.||...:::.:|....|..|||
  Rat   109 LTRLRHDEIITLLKNVGE---RVVLEVEYELPP-PAPENNPRIISKTVDVSLYKEGNSFGFVLRG 169

  Fly   200 GA------DYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYT 258
            ||      ..||::|:|||.||..:.|.:|.|||||.:|.:.|.|.:.|.|...::...|.:.: 
  Rat   170 GAHEDLHKSRPLVLTYVRPGGPADREGSLKVGDRLLSIDGIPLHGASHATAIATLQQCSHEALF- 233

  Fly   259 NLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAG 323
              .:||||:...:|..:.|||::||.:.....||:.|        .:||..:.|:          
  Rat   234 --QVEYDVATPDTVANASGPLVVEIAKTPGSALGISL--------TTGSHRNKPA---------- 278

  Fly   324 VFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPA--- 385
            :.|..|.|||:.||.|||..||.:|:||.|..||.:..  |...:|.:.|.:  .:::|:||   
  Rat   279 ITIDRIKPASVVDRSGALHAGDHILAIDGTSTEHCSLV--EATKLLASVTEK--VRLEILPAPQS 339

  Fly   386 ----------------------------HALARRGH-------------------TTLGSPKY-- 401
                                        |: .|..|                   |...||..  
  Rat   340 RRPLKPPEAVRIQRSEQLHHWDPCVPSCHS-PRPSHCRAPTWAPGGQDQSRSVSSTPFSSPTMNP 403

  Fly   402 -----SFSTLESRKSS---TAGRQRQRFARK---SSLPLENPACGTPGSTGGSMGTGG--IH--- 450
                 :.|||.....|   ||||:|||  ||   |||.|          ...::|.||  :|   
  Rat   404 AFPCANASTLPRGPMSPRTTAGRRRQR--RKEHRSSLSL----------ASSTVGPGGQIVHTET 456

  Fly   451 ------GSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSG 509
                  |....|.||.|              ..||..:||:     |....:..|.|||.|:|.|
  Rat   457 TEVVLCGDPLSGFGLQL--------------QGGIFATETL-----SSPPLVRFIEPDSPAERCG 502

  Fly   510 CIQAGDRIVAINKMYSLDAA--AMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVF 572
            .:|.|||::|||.:.:.|..  ...|||     |:.|.    |..:.||||||:.::|:|:||.|
  Rat   503 LLQVGDRVLAINGIATEDGTMEEANQLL-----RDAAL----ARKVVLEIEFDVAESVIPSSGTF 558

  Fly   573 SVKLLRAGKCGLGLSVSGSSH---GGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDA 634
            .|||.:.....||:::|.:|.   ..|:|||:|.||.|||:|:|..||.|||:|...:.|     
  Rat   559 HVKLPKRRGVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDH----- 618

  Fly   635 LLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYS 699
                                                     ||.                     
  Rat   619 -----------------------------------------CPM--------------------- 621

  Fly   700 SAYVTAGKYA--------DCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWS 756
                   :||        |.|.||.|..:                                    
  Rat   622 -------EYAVQILRQCEDLVKLKIRKDE------------------------------------ 643

  Fly   757 TGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSS 821
                                  :..||||                                    
  Rat   644 ----------------------DNSDEQE------------------------------------ 650

  Fly   822 KSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDE 886
             |||:    :.:||.|:..||.||||::|:|:....|.||||.:.|:|.:.|.|||||::|||:.
  Rat   651 -SSGA----VSYTVELKRYGGPLGITISGTEEPFDPIIISGLTKRGLAERTGAIHVGDRILAINS 710

  Fly   887 HSVQGMPLSHATSLLQNLGDLVDLKILRSHDL--------------------------------- 918
            .|::|.|||.|..|||..|:.|.|||.:..|.                                 
  Rat   711 VSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDVDEDPPEALKGGLLTTHF 775

  Fly   919 ------------------------ANGSHLPQTQAIYAKVQR-------------RPR------S 940
                                    .:||:.||........|.             .||      .
  Rat   776 SPAVPSVDSAVESWGSSATEGGFGGSGSYTPQVAVRSVTPQEWRSSRLKSSPPPLEPRRTSYTPG 840

  Fly   941 PSANTEASKESGS---------GNANGGG------------------------------------ 960
            |:..:...:|.|.         |.|...|                                    
  Rat   841 PTDESFPEEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLESCGQSELLRELEASIMTGTVQSV 905

  Fly   961 AVNGNSGSGKP-----------------------RVFHVTLYKDKVYDDYGFSVSDGLYERGVFI 1002
            ||:|..|| :|                       .:..|||:||.|.:|:||||||||.|:||::
  Rat   906 AVDGRPGS-RPWRRSREVGTSPEDLQELLLPTPLEMHRVTLHKDPVRNDFGFSVSDGLLEKGVYV 969

  Fly  1003 NRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQRS 1057
            :.:|..|||...| |:||||::|||.::|:||||||.|||:|.|||.:|:::.|:
  Rat   970 HTVRIDGPAQHGG-LQPFDRLLQVNHVRTRDFDCCLAVPLLAEAGDILELVVSRN 1023

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 18/66 (27%)
PDZ_signaling 183..254 CDD:238492 27/76 (36%)
PDZ_signaling 278..375 CDD:238492 31/96 (32%)
PDZ 496..>521 CDD:294084 12/24 (50%)
PDZ_signaling 571..658 CDD:238492 27/89 (30%)
PDZ_signaling 832..913 CDD:238492 40/80 (50%)
PDZ_signaling 973..1055 CDD:238492 46/81 (57%)
Grip2NP_612544.2 PDZ_signaling 51..133 CDD:238492 22/85 (26%)
PDZ_signaling 153..236 CDD:238492 28/85 (33%)
PDZ_signaling 251..334 CDD:238492 31/104 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 371..450 24/90 (27%)
PDZ_signaling 456..544 CDD:238492 33/115 (29%)
PDZ_signaling 557..640 CDD:238492 35/156 (22%)
PDZ_signaling 657..737 CDD:238492 40/79 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 745..769 0/23 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 786..863 10/76 (13%)
PDZ_signaling 941..1020 CDD:238492 46/79 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 105 1.000 Domainoid score I6515
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 432 1.000 Inparanoid score I1658
OMA 1 1.010 - - QHG46788
OrthoDB 1 1.010 - - D42090at33208
OrthoFinder 1 1.000 - - FOG0003379
OrthoInspector 1 1.000 - - otm46189
orthoMCL 1 0.900 - - OOG6_103747
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2278
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.740

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