DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Lnx1

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_001153049.1 Gene:Lnx1 / 16924 MGIID:1278335 Length:728 Species:Mus musculus


Alignment Length:722 Identity:152/722 - (21%)
Similarity:249/722 - (34%) Gaps:235/722 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 HHPPTDTALAPM--LSVDRAMSPAQSEDSGLAPERGTTY-------ATITLPRNALHLAITFAER 99
            ||..|....|..  |:.||..........|.|....||.       |||:|          ..:.
Mouse   126 HHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLMATTLSPEVSAAATISL----------MTDE 180

  Fly   100 NDLSYPPVVGSL---NPVGHAADF-------LAPGDRLHQIDGISTI-GLSNQKVMNMLCAGGSD 153
            ..|..|..|.|:   .||.:::|.       ..|.:|       ||: ..|.:|:...|.|....
Mouse   181 PGLDNPAYVSSVEDGEPVANSSDSGRSNRTRARPFER-------STMRSRSFKKINRALSALRRT 238

  Fly   154 ACPAIV----------EIEYSLPECTVSQNSLCVTSKLAQITVER--ESGCLGLTLRGGADYPL- 205
            ...::|          ....::||.......|....::..|.:.|  .|..|.:.|.||::.|| 
Mouse   239 KSGSVVANHVDQGRDNSENTTVPEVFPRLFHLIPDGEITSIKINRADPSESLSIRLVGGSETPLV 303

  Fly   206 --IVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIG-------KTLAEAQQIIKCGGHVSGYTNLT 261
              |:.|:...|.:.:.||:.|||.:|:|:.:.:..       :.|.:..|:::            
Mouse   304 HIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLR------------ 356

  Fly   262 IEYDVSVVQSVEF----------SMGP------LLIEIERPMNDKLGLVLCNYTAAVPASGSGSS 310
                ::|::..:|          |.||      :::....| .::||:.|.              
Mouse   357 ----LTVLREQKFRSRSNAHVPDSYGPRDDSFHVILNKSSP-EEQLGIKLV-------------- 402

  Fly   311 TPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGR 375
                 .:::| .||||.::|...:|||.|.|...|:||:|:...:...  ||:....::..|..|
Mouse   403 -----RRVDE-PGVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFG--SPESAAHLIQASERR 459

  Fly   376 GYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRF---ARKSSLPLENPACGTP 437
                     .|.:..|               :.|:||....|...:   .::|..|.|......|
Mouse   460 ---------VHLVVSR---------------QVRQSSPDIFQEAGWISNGQQSPGPGERNTASKP 500

  Fly   438 GSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSG-----AVAIA 497
            .:|                     |..:...|..|.|...|:.:     |.|.|.     .:.:.
Mouse   501 AAT---------------------CHEKVVSVWKDPSESLGMTV-----GGGASHREWDLPIYVI 539

  Fly   498 QIVPDSVADRSGCIQAGDRIVAINK--------------MYSLDAAAMRQLLE----------GG 538
            .:.|..|..|.|.|:.||.::.:|.              :.|..::.:.:.||          ..
Mouse   540 SVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILKSAPSSVVLKALEVKEQEAQEDCSP 604

  Fly   539 SSRNGASNGTPAN--------WLELEIEFDMPDAVVPASGVFSVKLLRAGKCG-LGLSVSG---- 590
            ::.:...|.||..        ||||      |..:.....|    :||....| ||..:.|    
Mouse   605 AALDSNHNVTPPGDWSPSWVMWLEL------PQYLCNCKDV----ILRRNTAGSLGFCIVGGYEE 659

  Fly   591 -SSHGGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQ---HFNVDALLKE-EGRSQNPSHSSS 650
             |.:....|..:..|:||:..|.:|.|||||||:.....   |..:..:||| :||         
Mouse   660 YSGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARMLKELKGR--------- 715

  Fly   651 DFTTLTI 657
              .||||
Mouse   716 --ITLTI 720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 16/75 (21%)
PDZ_signaling 183..254 CDD:238492 21/82 (26%)
PDZ_signaling 278..375 CDD:238492 23/102 (23%)
PDZ 496..>521 CDD:294084 7/24 (29%)
PDZ_signaling 571..658 CDD:238492 31/97 (32%)
PDZ_signaling 832..913 CDD:238492
PDZ_signaling 973..1055 CDD:238492
Lnx1NP_001153049.1 mRING-HC-C3HC3D_LNX1 42..83 CDD:319693
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 185..220 9/41 (22%)
NPXY motif 185..188 1/2 (50%)
Interaction with MAGEB18. /evidence=ECO:0000250 186..244 14/64 (22%)
PDZ_signaling 276..360 CDD:238492 21/99 (21%)
PDZ_signaling 384..464 CDD:238492 24/111 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..500 3/18 (17%)
PDZ_signaling 506..589 CDD:238492 16/87 (18%)
PDZ_signaling 637..721 CDD:238492 31/99 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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