DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Il16

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_001347016.1 Gene:Il16 / 16170 MGIID:1270855 Length:1424 Species:Mus musculus


Alignment Length:1455 Identity:278/1455 - (19%)
Similarity:463/1455 - (31%) Gaps:543/1455 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 LWK--SKKPIGGC-------------VPGK------------SAALKQDQQQQQQQQQESHNNS- 39
            ||.  .:.|:.||             |||:            |:...:.:..:|::::....:| 
Mouse    37 LWHIYRRTPLLGCQATSPRPLCSWHLVPGRANWTHAVAAKSSSSVTHRPRPGEQERKKRGLTSSL 101

  Fly    40 -FNGHHHPPTDTALAPMLSVDRA--MSPAQSEDSGLAPE---------------RGTTYATITL- 85
             ...|.|...........|:.|:  :..|::.|.|.:|:               .|..::::.| 
Mouse   102 RMEPHGHSGKSRKSTKFRSISRSLILCNAKTSDDGSSPDEKYPDPFETSLCQGKEGFFHSSMQLA 166

  Fly    86 ----------PRNAL----------------HLAITFAERNDLSYPPVVGSLNPVGHAADFLAPG 124
                      |..||                |....|..:...|......|..|...::.||.| 
Mouse   167 DTFEAGLSNIPDLALASDSAQLAAAGSDRGKHCRKMFFMKESSSTSSKEKSGKPEAQSSSFLFP- 230

  Fly   125 DRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQN-----SLC-------- 176
            ...||..      .||...:|...||         ||::.:.:.:.:..     |||        
Mouse   231 KACHQRT------RSNSTSVNPYSAG---------EIDFPMTKKSAAPTDRQPYSLCSNRKSLSQ 280

  Fly   177 ----------------VTSKLAQIT-------------VERESGCLGLTLRGGAD--YPLIVTHV 210
                            .|::|.|::             ::.::..||.::.||.|  |..|..:|
Mouse   281 QLDYPILGTARPTRSLSTAQLGQLSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYV 345

  Fly   211 R---PHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSV 272
            :   ..|.....||::.||.:|.::..|:.|.|..:|.|..|..  ..|...||:...::...|:
Mouse   346 KSIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA--KKGLLTLTVRTRLTTPPSL 408

  Fly   273 EFSMGPLLIEIERPMNDKLGLVLCN------YTAAVPASGSGSSTPSSGEKIEES---------- 321
            ...:.|       |:...|....|.      ::...|||.:.::.|:....:|.|          
Mouse   409 CSHLSP-------PLCRSLSSSTCGAQDSSPFSLESPASPASTAKPNYRIMVEVSLKKEAGVGLG 466

  Fly   322 ------------AGVFIASILPASIADRCGALSVGDQVLSIDD------------TMIEHTAFSP 362
                        :|:|:.::.|.|:|...|.|..||:::.|:|            |::.|.  .|
Mouse   467 IGLCSIPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEINDSPVHCLTLNEVYTILSHC--DP 529

  Fly   363 DEVMTILDTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFS---------------TLESRK-- 410
            ..|..|:........::.|:..|.|.|..| ...|..::.:|               |||..:  
Mouse   530 GPVPIIVSRHPDPQVSEQQLKEAVAQAVEG-VKFGKDRHQWSLEGVKRLESSWHGRPTLEKEREK 593

  Fly   411 -SSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGT--------GGIHGSSSLGMG-------- 458
             |:...|:.|:...:||.. .:...|:||.:..|.|.        |..| |.||..|        
Mouse   594 HSAPPHRRAQKIMVRSSSD-SSYMSGSPGGSPCSAGAEPQPSEREGSTH-SPSLSPGEEQEPCPG 656

  Fly   459 -----------------------LGLCRAESFPVLL------------------DCSHGAGIILS 482
                                   |.|  .:||.:|:                  |......:...
Mouse   657 VPSRPQQESPPLPESLERESHPPLRL--KKSFEILVRKPTSSKPKPPPRKYFKNDSEPQKKLEEK 719

  Fly   483 ETVSGSGGSGAVAIAQ--------IVPDSVADRSGCIQA---GDRIVAINKMYSLDAAAMRQLLE 536
            |.|:...|......:|        ::.:..|.|:.|..|   |             .||..|...
Mouse   720 EKVTDPSGHTLPTCSQETRELLPLLLQEDTAGRAPCTAACCPG-------------PAASTQTSS 771

  Fly   537 G--GSSRNGASNGTPAN---------WLELEIEFDM--PDAVVPAS----GVFS---------VK 575
            .  |.||..||..|||:         ...::..||:  .|..|..|    .:||         ..
Mouse   772 STEGESRRSASPETPASPGKHPLLKRQARMDYSFDITAEDPWVRISDCIKNLFSPIMSENHSHTP 836

  Fly   576 LLRAGKCGLGLSVSGSSHGGLVISDVKMGSP-AHRS--GSL------------------------ 613
            |......|......|...|||...|...|:| .::|  ||.                        
Mouse   837 LQPNTSLGEEDGTQGCPEGGLSKMDAANGAPRVYKSADGSTVKKGPPVAPKPAWFRQSLKGLRNR 901

  Fly   614 -----RSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIV----------LP 663
                 |..::..|:...||         ..:.....|..|||      |::.:          ||
Mouse   902 APDPRRPPEVASAIQPTPV---------SRDPPGPQPQASSS------IRQRISSFENFGSSQLP 951

  Fly   664 D------FLPMSSPIYSNCPA-------SGINLGMGMGVST---STDHDLYSSAYVTAGKYAD-- 710
            |      .|..||...:..|.       ||: ||.|..|:.   .|:.:..|:.:..:.:..|  
Mouse   952 DRGVQRLSLQPSSGETTKFPGKQDGGRFSGL-LGQGATVTAKHRQTEVESMSTTFPNSSEVRDPG 1015

  Fly   711 ---------CVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVA 766
                     ..|.|:.:|.| ..|:.:......|      |.|....:|.|.|:..         
Mouse  1016 LPESPPPGQRPSTKALSPDP-LLRLLTTQSEDTQ------GPGLKMPSQRARSFPL--------- 1064

  Fly   767 PPNTQSLTTELPEEEDE---------------------------------QEQMYP--------- 789
             ..|||..|:|.:|:..                                 :|::.|         
Mouse  1065 -TRTQSCETKLLDEKASKLYSISSQLSSAVMKSLLCLPSSVSCGQITCIPKERVSPKSPCNNSSA 1128

  Fly   790 ------------GYELN-----RYASVDCTALPPPMENKVYGSAASSSSKS-----SGSSLHQII 832
                        |:.||     .|:.    .|..|.|.:.....:|.:.:|     |...|.::|
Mouse  1129 AEGFGEAMASDTGFSLNLSELREYSE----GLTEPGETEDRNHCSSQAGQSVISLLSAEELEKLI 1189

  Fly   833 FTVRL------------------EPKGGLLGITLAGSEDI-TKSITISGLVEGGIAHKNGQIHVG 878
            ..||:                  :.:|..||.:|||..|: .|.||:..:...|:|.:.|.|..|
Mouse  1190 EEVRVLDEATLKQLDSIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKG 1254

  Fly   879 DQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLPQTQAIYAKVQRRPRSPSA 943
            :::|:|:..|::|...:.|.::|:...|                  |:...|   |.||     .
Mouse  1255 NEVLSINGKSLKGATHNDALAILRQARD------------------PRQAVI---VTRR-----T 1293

  Fly   944 NTEASKESGSGN---ANGGGAVNGNSGSGKPRVFHVTLYKDKVYDDYGFSVSDG---LY-ERGVF 1001
            ..||:.:..|..   |:...|.:.:..|.:..|..|||  :|.....|||:..|   |: ::.:.
Mouse  1294 TVEATHDLNSSTDSAASASAASDISVESKEATVCTVTL--EKTSAGLGFSLEGGKGSLHGDKPLT 1356

  Fly  1002 INRIRSGGPADMCGLLKPFDRIMQV 1026
            ||||..|  .:...:::|.|.|:|:
Mouse  1357 INRIFKG--TEQGEMVQPGDEILQL 1379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 17/91 (19%)
PDZ_signaling 183..254 CDD:238492 21/88 (24%)
PDZ_signaling 278..375 CDD:238492 26/136 (19%)
PDZ 496..>521 CDD:294084 6/35 (17%)
PDZ_signaling 571..658 CDD:238492 22/127 (17%)
PDZ_signaling 832..913 CDD:238492 25/99 (25%)
PDZ_signaling 973..1055 CDD:238492 19/58 (33%)
Il16NP_001347016.1 PDZ_signaling 316..391 CDD:238492 20/76 (26%)
PDZ_signaling 454..536 CDD:238492 17/83 (20%)
Atrophin-1 <620..931 CDD:331285 60/335 (18%)
PDZ_signaling 1206..1283 CDD:238492 22/94 (23%)
PDZ_signaling 1328..1409 CDD:238492 18/56 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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