DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and FRMPD2

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_001018081.4	Gene:	FRMPD2 / 143162	HGNCID:	28572	Length:	1309	Species:	Homo sapiens

Alignment Length:	1161	Identity:	232/1161 - (19%)
Similarity:	377/1161 - (32%)	Gaps:	359/1161 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DQQQQQQQQQESHNNSFNGHHHPPTDTALAPMLSVDRAMSPAQSEDSGLAPERGTTYATITLPRN 88
            ::..:.|...|.|.::.. |.|        ..|.|:||:..|..:|.         .|...|...
Human   236 ERSTETQSSPEPHWSTLT-HSH--------CSLLVNRALPGADPQDQ---------QAGRRLSSG 282

  Fly    89 ALHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGG-- 151
            ::|.|.      |.|:|........:...:.|..|          ..|.|:.:..|.:...|.
Human   283 SVHSAA------DSSWPTTPSQRGFLQRRSKFSRP----------EFILLAGEAPMTLHLPGSVV 331

  Fly   152 ----------SDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGADYPLI 206
                      .|.|..::..::...:|.|......|.:.:.......|....||......::..:
Human   332 TKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFL 396

  Fly   207 VTHVR-----PHG---PVYKTG--------RIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVS 255
            .:..|     |.|   ...||.        |||     ..|.:..|:..:|...|..::....:
Human   397 DSETRLCKIAPEGWREQPQKTSMNTFTLFLRIK-----FFVSHYGLLQHSLTRHQFYLQLRKDI- 455

  Fly   256 GYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEE 320
                  :|..:...:.:...:|.|.::.|          ..||..               |::|.
Human   456 ------LEERLYCNEEILLQLGVLALQAE----------FGNYPK---------------EQVES 489

  Fly   321 SAGVFIASILPASIADRCGALSVGDQVLSI---------DDT---------------MIEHTAFS 361
            .....:...:|||:.:|..||.|..:|..:         :|.               ::.|..||
Human   490 KPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFS 554

  Fly   362 ----PDEVMTILDTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESR---KSSTAGRQRQ 419
                |:|.|.:...:.|....:::.....|:.|......|    ..||.:.:   .||..|: :.
Human   555 EKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETG----KISTYQKKFTITSSVTGK-KH 614

  Fly   420 RF----ARKSSLPLENPACGTPGSTGGSMGTGG------IHGSSSLGMGLGLC-RAESFPVL--- 470
            .|    |:.|...|:  .|.........||:|.      .|........|... :|.|.|::
Human   615 TFVTDSAKTSKYLLD--LCSAQHGFNAQMGSGQPSHVLFDHDKFVQMANLSPAHQARSKPLIWIQ 677

  Fly   471 -LDCSH----------GAGIILSET-----VSGSGGSGAVAIAQIVPDSVAD--RSGCIQAGDRI 517
             |.||.          .||.:||.:     |.||..:||..|.: .|.:..:  :|.|:
Human   678 RLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGR-SPCTGREQLKSACV------ 735

  Fly   518 VAINKMYSLDAAAMRQLLEG---GSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRA 579
              |.|..:.|:      |.|   .|...|:.|....:::           ..|...:..|.|.|.
Human   736 --IQKPMTWDS------LSGPPVQSMHAGSKNNRRKSFI-----------AEPGREIVRVTLKRD 781

  Fly   580 GKCGLGLSV-----SGSSHGGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEE 639
            ...|.|..:     ||.:..|:.||.:..|.||.::.:::.|..:||::...::.|..:..::
Human   782 PHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR-- 844

  Fly   640 GRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVT 704
             ..||    |.|...|.|.:         |..:..|.|....|.....|||::   |:.|..|..
Human   845 -MIQN----SPDNIELIISQ---------SKGVGGNNPDEEKNSTANSGVSST---DILSFGYQG 892

  Fly   705 AGKYADCVSLKSRTPQPDYFRVPSMDDASLQSV--QLR--------SGSGSNGGNQAANSWSTGV 759
                    ||.|.|...|. ....:|.|.:||:  :||        .|:||:
Human   893 --------SLLSHTQDQDR-NTEELDMAGVQSLVPRLRHQLSFLPLKGAGSS------------- 935

  Fly   760 NSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSS 824
                  .||:                                   ||.:              |:
Human   936 ------CPPS-----------------------------------PPEI--------------SA 945

  Fly   825 GSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISG-----LVEGGIAHKNGQIHVGDQLLAI 884
            |.     |:.|.|..:.|.||.::.|.  |..|:...|     :|.||.|.|.|||..||:||.:
Human   946 GE-----IYFVELVKEDGTLGFSVTGG--INTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQV 1003

  Fly   885 DEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLPQTQAIYAKVQRRPRS----PSANT 945
            |...:.|:....|...|...|.:..|.:.|                     |.|||    ||||.
Human  1004 DGVILCGLTHKQAVQCLTGPGQVARLVLER---------------------RVPRSTQQCPSAND 1047

  Fly   946 EASKESGSGN---ANGGGAVNGNSGSGKPRVFHVTLYKDKVYDDYGFSV-------SDGLYERGV 1000
            ....|..:.:   |..|...:..|.:..|: |.|.|.|:.  :..|||.       ...|....|
Human  1048 SMGDERTAVSLVTALPGRPSSCVSVTDGPK-FEVKLKKNA--NGLGFSFVQMEKESCSHLKSDLV 1109

  Fly  1001 FINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQR 1056
            .|.|:..|.||:..|.:...|.|:.||...|:.......:.|:..|..::.:::.|
Human  1110 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	11/64 (17%)
		PDZ_signaling	183..254	CDD:238492	15/86 (17%)
		PDZ_signaling	278..375	CDD:238492	21/124 (17%)
		PDZ	496..>521	CDD:294084	4/26 (15%)
		PDZ_signaling	571..658	CDD:238492	22/91 (24%)
		PDZ_signaling	832..913	CDD:238492	28/85 (33%)
		PDZ_signaling	973..1055	CDD:238492	22/88 (25%)
FRMPD2	NP_001018081.4	KIND	15..197	CDD:214801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..249		2/12 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..302		9/50 (18%)
		B41	346..550	CDD:214604	35/240 (15%)
		FERM_C_PTPH13	546..647	CDD:270008	23/107 (21%)
		PDZ_signaling	773..857	CDD:238492	22/90 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..880		4/29 (14%)
		PDZ	947..1034	CDD:214570	29/114 (25%)
		PDZ	1078..1167	CDD:214570	23/90 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810