DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and Lnx2

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_542985.4 Gene:Lnx2 / 140887 MGIID:2155959 Length:687 Species:Mus musculus


Alignment Length:714 Identity:139/714 - (19%)
Similarity:244/714 - (34%) Gaps:244/714 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PGKS---AALKQDQQQQQQQQQESHNNSFNGHHHPPTDTALAPMLSVDRAMSPAQSEDSGLAP-E 75
            ||.|   ..|::.:..|.|.|.|....|          |.:.|..::     |.:::.||..| |
Mouse   139 PGASHRRVDLERRKTSQTQTQIEGETGS----------TVIDPPGTL-----PPETDCSGTVPGE 188

  Fly    76 RGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLSN 140
            |..|.|::.:          :.|...|..|           |.:..|..|.:.|           
Mouse   189 RNLTPASLPV----------WTEEPGLDNP-----------AFEESAAADSVQQ----------- 221

  Fly   141 QKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGC--LGLTLRGGADY 203
                                 ..||||           .::..|.:.|.:..  ||:::.||.:.
Mouse   222 ---------------------PLSLPE-----------GEITTIEIHRSNPYIQLGISIVGGNET 254

  Fly   204 PLI---VTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQII---------------KC 250
            |||   :..|...|.:.:.||:..||::|:|:|..:...:...|:.::               :.
Mouse   255 PLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYDISNVSHNHARAVLSQPCSTLQLTVLRERRF 319

  Fly   251 GGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSG 315
            |...:.:.      |.|..:...|.   :|:. :|...::||:.|...|                
Mouse   320 GSRANSHA------DGSAPRDEVFQ---VLLH-KRDSTEQLGIKLVRRT---------------- 358

  Fly   316 EKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQM 380
                :..||||..:|...:|.:.|.|:..|:||:|:...::|.  :|:....|:..|        
Mouse   359 ----DEPGVFILDLLEGGLAAQDGRLNSNDRVLAINGHDLKHG--TPELAAQIIQAS-------- 409

  Fly   381 QIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMG 445
                    ..|.:.|:..|         .|...:...|:..|..||...:.|:...|||      
Mouse   410 --------GERVNLTIARP---------GKPQPSNGSREAGAHSSSNHAQPPSHSRPGS------ 451

  Fly   446 TGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGA----VAIAQIVPDSVAD 506
                |...:..:   .|:.:...|..:.....|:    ||:|..||.:    :.:..:.|.....
Mouse   452 ----HKDLTRCV---TCQEKHITVKKEPHESLGM----TVAGGRGSKSGELPIFVTSVPPHGCLA 505

  Fly   507 RSGCIQAGDRIVAIN-----KMYSLDAAAMRQLLEGGSSRNGASNGTPA---NWLELEIEFDMPD 563
            |.|.|:.||.::.||     .:...:|.||.:          ||..:||   ..||::|..:...
Mouse   506 RDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK----------ASAASPAVILKALEVQIAEEAAQ 560

  Fly   564 AVVPASGVFS---------------------------VKLLRAGKCGLGLSVSGS-----SHGGL 596
            |.......||                           :.|.|:.....|.|:.|.     ::...
Mouse   561 ATEEQPSAFSENEYDASWSPSWVMWLGLPSALHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPF 625

  Fly   597 VISDVKMGSPAHRSGSLRSGDILLAVD---QHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTI 657
            .|..:.:|:||:..|.|:.||:::||:   ...:.|..:..:|||:...          .|||:
Mouse   626 FIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNK----------VTLTV 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 7/64 (11%)
PDZ_signaling 183..254 CDD:238492 20/90 (22%)
PDZ_signaling 278..375 CDD:238492 22/96 (23%)
PDZ 496..>521 CDD:294084 6/24 (25%)
PDZ_signaling 571..658 CDD:238492 24/122 (20%)
PDZ_signaling 832..913 CDD:238492
PDZ_signaling 973..1055 CDD:238492
Lnx2NP_542985.4 mRING-HC-C3HC3D_LNX2 46..90 CDD:319694
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 145..175 8/39 (21%)
NPXY motif 207..210 1/13 (8%)
PDZ 229..315 CDD:214570 19/85 (22%)
PDZ_signaling 336..418 CDD:238492 25/123 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 417..454 11/55 (20%)
PDZ_signaling 463..539 CDD:238492 18/89 (20%)
PDZ_signaling 596..680 CDD:238492 22/94 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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