DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and Dlg4

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_001357604.1 Gene:Dlg4 / 13385 MGIID:1277959 Length:764 Species:Mus musculus


Alignment Length:497 Identity:99/497 - (19%)
Similarity:174/497 - (35%) Gaps:179/497 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   605 SPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMS 669
            ||||......|..:::          |.|.|  |.....|.:....::..:|::|          
Mouse    68 SPAHLPNQANSPPVIV----------NTDTL--EAPGYVNGTEGEMEYEEITLER---------- 110

  Fly   670 SPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSM-DDAS 733
                      | |.|:|..::..||:                               |.: ||.|
Mouse   111 ----------G-NSGLGFSIAGGTDN-------------------------------PHIGDDPS 133

  Fly   734 LQSVQ-LRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYA 797
            :...: :..|:.:..|....|.....||                   |.|.:|            
Mouse   134 IFITKIIPGGAAAQDGRLRVNDSILFVN-------------------EVDVRE------------ 167

  Fly   798 SVDCTALPPPMENKVYGSAASSSSKSSGSSLH----------QIIFTVRL--EPKGGLLGITLA- 849
                          |..|||..:.|.:||.:.          :.|..::|  .|||  ||.::| 
Mouse   168 --------------VTHSAAVEALKEAGSIVRLYVMRRKPPAEKIIEIKLIKGPKG--LGFSIAG 216

  Fly   850 --GSEDI--TKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDL 910
              |::.|  ..||.::.::|||.|||:|::.:||::||::...::.:....|.:.|:|..|:|.|
Mouse   217 GVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYL 281

  Fly   911 KILR---------------------------SHDLANGSHLPQTQAIYAKVQRRPRSPSANTEAS 948
            |:.:                           ||....|:..|....        |.||...:..:
Mouse   282 KVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMT--------PTSPRRYSPVA 338

  Fly   949 KESGSGNANGGGAVNGNSGSGKPRVFHVTLYKDKVYDDYGFSVSDGLYERGVFINRIRSGGPADM 1013
            |:          .:.......:||  .:.:::...  ..||::..|....|:||:.|.:|||||:
Mouse   339 KD----------LLGEEDIPREPR--RIVIHRGST--GLGFNIVGGEDGEGIFISFILAGGPADL 389

  Fly  1014 CGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQ 1055
            .|.|:..|:|:.||.:..::.........:..||..:.:|.|
Mouse   390 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492
PDZ 496..>521 CDD:294084
PDZ_signaling 571..658 CDD:238492 11/52 (21%)
PDZ_signaling 832..913 CDD:238492 30/87 (34%)
PDZ_signaling 973..1055 CDD:238492 21/81 (26%)
Dlg4NP_001357604.1 L27 <26..47 CDD:351851
MAGUK_N_PEST 54..104 CDD:337803 10/47 (21%)
PDZ 105..189 CDD:334167 27/180 (15%)
PDZ 197..287 CDD:214570 30/91 (33%)
PDZ_assoc 285..352 CDD:313755 8/84 (10%)
PDZ 350..434 CDD:214570 24/86 (28%)
SH3_DLG4 470..535 CDD:212963
Guanylate_kin 573..751 CDD:279019
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23119
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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