DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and Patj

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_766284.2	Gene:	Patj / 12695	MGIID:	1277960	Length:	1834	Species:	Mus musculus

Alignment Length:	1391	Identity:	277/1391 - (19%)
Similarity:	447/1391 - (32%)	Gaps:	487/1391 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PGKSAALKQDQQQQQQQQQESHNNSFNGHHHPPT-----------------DTALAPMLSVDRAM 62
            |...|.|..:.::..::.....||:......|..                 :..|.|...|..|.
Mouse   483 PKPEANLSVEAEEIGERLDNLKNNTVQALEKPDVYPEKVPGSPENELKSRWENLLGPDYEVMVAT 547

  Fly    63 SPAQSEDSGLAPERGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVG--HAADFLAPGD 125
            ..||..|.    |....|:.: ||.:.|.|.:.....:...|   :.|:.|.|  ...:.|.|.|
Mouse   548 LDAQIADD----EELQKYSKL-LPIHTLRLGMEVDSFDGHHY---ISSVAPGGPVDTLNLLQPED 604

  Fly   126 RLHQIDGISTIGLSNQKVMNML----------CAGGSDAC-----------------PAIVEIEY 163
            .|.:::|:...|.|.::.::.|          |      |                 ||::|.|.
Mouse   605 ELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVC------CRRLFDDEASVDEPRTMEPALLEAEV 663

  Fly   164 SLPECTVSQN-------SLCVTSKLAQITVERESGCLGLTLRGGADY--PL-------IVTHVRP 212
               :.:|..|       .|.:.|...: |||....|.||.. ...||  ||       ::..:..
Mouse   664 ---DHSVDVNIEDDDDGELALWSPEVK-TVELVKDCKGLGF-SILDYQDPLDPTRSVIVIRSLVA 723

  Fly   213 HGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKC--------------------------- 250
            .|...::|.:.|||||:.|:..||...|||||.:::|.
Mouse   724 DGVAERSGELLPGDRLVSVNEFSLDNATLAEAVEVLKAVPPGVVHLGICKPLVEDEKEERFSLHS 788

  Fly   251 --GGHVSGYTNLTIEYDVSVVQSVEFSMG----PLLIE-IERPMNDKLGLVLCNYTAAVPASGSG 308
              .|..|...:...|...|::  :|...|    |.|.| ::.|..| ||..|......|.:|...
Mouse   789 NNNGDSSEPADAVHEIHSSLI--LEAPQGFRDEPYLEELVDEPFLD-LGKSLQFQQKDVDSSSEA 850

  Fly   309 ------SSTPSSG-------------EKIEESAGVFIASILPASIADRCGA-----LSVGDQVLS 349
                  .|.|..|             |..::......::..|..|.:...|     |..|.|.|
Mouse   851 WEMHEFLSPPLDGRGEEREMLVDEEYELYQDHLRAMESNPPPPHIREAAPASPVLELQAGTQWL- 914

  Fly   350 IDDTMIEHTAFSPDEVMTILDT-STGRGYTQ-MQIMPAHALARRGHTTLGSPKYSFSTLESRKSS 412
                   |...|..|.:...|. |....|.| ||                  :||:        |
Mouse   915 -------HANLSGGERLECHDAESMMSAYPQEMQ------------------QYSY--------S 946

  Fly   413 TAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHG--SSSLGMG----------------- 458
            ||....:.|...|..|:  |:....|..|.....|.:|.  ||||.:|
Mouse   947 TADMMEETFGLDSRAPI--PSSEGNGQHGRFDDMGHLHSLTSSSLDLGMMIPSDLQGPGVLVDLP 1009

  Fly   459 ----------LGLCRAESFPVLLDCSHGAGIILS------------------ET----------- 484
                      |.|.|..|..|:...|...|::.|                  ||
Mouse  1010 AVAQRREQEDLPLYRLPSARVVTKPSSHMGLVSSRHANAACELPEREEGEGEETPNFSHWGPPRI 1074

  Fly   485 ------------VSGSGGSGAVA------------IAQIVPDSVADRSGCIQAGDRIV---AINK 522
                        :|..||...:.            |.|::.||.|.::..::.||:|:   .::.
Mouse  1075 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDL 1139

  Fly   523 MYSLDAAAMRQLLEGGS-----------------------------------SRNGASNGTPANW 552
            ..:..|.|:..:...|:                                   .|....:||....
Mouse  1140 QNASHAEAVEAIKSAGNPVVFVVQSLSSTPRVIPTVNNKGKTPAPNQDQNTQERKAKRHGTAPPP 1204

  Fly   553 LELEIEFDMPDAVVPAS-------------------GVFSVKLLRAGKCGLGLSVSGS---SHGG 595
            ::|...:..|.|.:..|                   |...:..|...|.|||||::|:   |...
Mouse  1205 MKLPPPYRAPSADMEGSEEDCALTDKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMS 1269

  Fly   596 LVISDVKMGSPAHRSGSLRSGDILLAVDQHPV---QHFNVDALLKEEGRSQNPSHSSSDF--TTL 655
            :.:..:....||...|.:|.||.||.::...:   .|.|..|::|..     |:.....|  ...
Mouse  1270 IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTA-----PTRVKLVFIRNED 1329

  Fly   656 TIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQ 720
            .:.::.:..|     |..|:.|:...:|| |..:.:|.:.....:.::               |:
Mouse  1330 AVSQMAVAPF-----PELSHSPSPVEDLG-GTELVSSEEESSVDAKHL---------------PE 1373

  Fly   721 PDYFRVPSM----DDASLQSVQLRSGSGSNGGNQ-AANSWSTGVNSRSYVAP----PNTQSLTTE 776
            |:..:...:    ||..:...|..|.|..:...| ...::||.|:|.|..:|    |..||...:
Mouse  1374 PESSKPEDLSQVVDDNMVAEQQKESESPDSAACQIKQQTYSTQVSSSSQDSPSSPAPLCQSAHAD 1438

  Fly   777 LPEEEDEQEQM----------------YPGYE-------------LNRYASVDCTALPPPMENKV 812
            :....:.|..:                .||.|             |:.....| |.|...:.::|
Mouse  1439 VTGSGNFQAPLPVDPAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKD-TPLDAIVIHEV 1502

  Fly   813 Y--GSAA--------------------SSSSKSSGSSLHQI----------------------IF 833
            |  |:||                    |||.:.:.::|.|.                      :|
Mouse  1503 YEEGAAARDGRLWAGDQILEVNGVDLRSSSHEEAITALRQTPQKVRLVVYRDEAQYRDEENLEVF 1567

  Fly   834 TVRLEPKGGL-LGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHA 897
            .|.|:.|.|. ||:::.|... ...:.||.:|:||.|..:|::..|||:|     ||.|..:.||
Mouse  1568 LVDLQKKTGRGLGLSIVGKRS-GSGVFISDIVKGGAADLDGRLIRGDQIL-----SVNGEDMRHA 1626

  Fly   898 T-----SLLQNLGDLVDLKILRSHDLANGSHLPQTQAIYAKVQRRPRSPSANTEASKESGSGNAN 957
            :     ::|:.:..||.|:|.|   |..||....            |..|.|::..:.|...:..
Mouse  1627 SQETVATILKCVQGLVQLEIGR---LRAGSWAAS------------RKTSQNSQGDQHSAHSSCR 1676

  Fly   958 GGGA--------VNGNSGSG---------KPRVFHVTLYKDKVYDDYGFSVSDG----LYERGVF 1001
            ...|        :.|...|.         :||...:.   .::.|..|.|::.|    |.:..:|
Mouse  1677 PSFAPVITSLQNLVGTKRSSDPPQKCTEEEPRTVEII---RELSDALGISIAGGKGSPLGDIPIF 1738

  Fly  1002 INRIRSGGPADMCGLLKPFDRIMQVN 1027
            |..|::.|.|.....||..|||:.:|
Mouse  1739 IAMIQANGVAARTQKLKVGDRIVSIN 1764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	15/66 (23%)
		PDZ_signaling	183..254	CDD:238492	27/108 (25%)
		PDZ_signaling	278..375	CDD:238492	26/122 (21%)
		PDZ	496..>521	CDD:294084	8/27 (30%)
		PDZ_signaling	571..658	CDD:238492	23/94 (24%)
		PDZ_signaling	832..913	CDD:238492	28/86 (33%)
		PDZ_signaling	973..1055	CDD:238492	16/59 (27%)
Patj	NP_766284.2	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	248..325	CDD:238492
		PDZ_signaling	363..450	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..488		1/4 (25%)
		PDZ_signaling	572..636	CDD:238492	13/66 (20%)
		PDZ	685..774	CDD:214570	26/90 (29%)
		PDZ_signaling	1072..1163	CDD:238492	14/90 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1219		6/47 (13%)
		PDZ	1242..1327	CDD:214570	23/89 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1453		25/128 (20%)
		MPDZ_u10	<1453..1468	CDD:374710	0/14 (0%)
		PDZ	1469..1554	CDD:214570	15/85 (18%)
		PDZ_signaling	1566..1646	CDD:238492	28/85 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1657..1676		4/30 (13%)
		PDZ_signaling	1707..1792	CDD:238492	18/61 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1811..1834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810