DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and PARD3B

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_011508854.1	Gene:	PARD3B / 117583	HGNCID:	14446	Length:	1213	Species:	Homo sapiens

Alignment Length:	1221	Identity:	235/1221 - (19%)
Similarity:	393/1221 - (32%)	Gaps:	419/1221 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VPGKSAALKQDQQQQQQQQQESHNNSFNGHHHPPT-DTALAPMLSVDRAMSPAQSEDSGLAPERG 77
            |..|...:...::|:...:.||.:.:......|.. :|.:|..|:   |..|...|
Human    77 VEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLA---AFKPIGGE--------- 129

  Fly    78 TTYATITLPRNALHLAITFAERNDLSYPPVVG--------SLNPVGHAADFLAPGDRLHQIDGIS 134
                 |.:..:||.|......|.  |..||.|        :.:|.|.:...:.|.         |
Human   130 -----IEVTPSALKLGTPLLVRR--SSDPVPGPPADTQPSASHPGGQSLKLVVPD---------S 178

  Fly   135 TIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGL---- 195
            |..|.:::|:|              .::..|.....::::|...::..:|:  .|.|.||:
Human   179 TQNLEDREVLN--------------GVQTELLTSPRTKDTLSDMTRTVEIS--GEGGPLGIHVVP 227

  Fly   196 --TLRGGADYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGG------ 252
              :...|....|.:..:..:....:.|.....:.:::::||.|:.||.|:||.:.:...
Human   228 FFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVL 292

  Fly   253 -HVSGYTNLTIEYDVSVVQSVEF---SMGPLLIEIERPMNDKLGLVLCNYTAA------------ 301
             ||....|.. :|:.||:.|:..   :.|.|..::..|::.|.||...|.|..
Human   293 LHVLPPQNRE-QYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQ 356

  Fly   302 ------VPASGSGSSTPS-----------SGEKIE-------ESAG---------------VFIA 327
                  ||..|...|:||           :.:||:       |..|               :|:.
Human   357 QNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVK 421

  Fly   328 SILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIM---PAHALA 389
            :|||...|.:.|.|..||::|.::...:  |..:.:|::.:| .||.:|.|...::   ..|.|.
Human   422 NILPKGAAIKDGRLQSGDRILEVNGRDV--TGRTQEELVAML-RSTKQGETASLVIARQEGHFLP 483

  Fly   390 RRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTG-GIHGSS 453
            |.   ..|.|.....:||:.:..|           ..:||.:         .||.|.| .:.|:.
Human   484 RE---LKGEPDCCALSLETSEQLT-----------FEIPLND---------SGSAGLGVSLKGNK 525

  Fly   454 SLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIV 518
            |...|..|                ||.:...:.|    ||           |.:.|.::..|:::
Human   526 SRETGTDL----------------GIFIKSIIHG----GA-----------AFKDGRLRMNDQLI 559

  Fly   519 AINKMYSLDAA---AMRQLLEGGSSRNGASNGTPANWLELEI----EFDMPDAVVPAS-GVFSVK 575
            |:|....|..:   ||..|     .|:.:..|.....::|.|    |..|.|   ||. |.||..
Human   560 AVNGESLLGKSNHEAMETL-----RRSMSMEGNIRGMIQLVILRRPERPMED---PAECGAFSKP 616

  Fly   576 -------------------LLRAGKC-------GLGLSVSG----------SSHG--GLVISDVK 602
                               |...|.|       ||.|...|          :.|.  ||.:.|.
Human   617 CFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLEDY- 680

  Fly   603 MGSPAHRSGSLRSGDILLAVDQ---HPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPD 664
                :|.||          ||.   .|.||.|.        ||..|:....   ::.:|.....|
Human   681 ----SHSSG----------VDSAVYFPDQHINF--------RSVTPARQPE---SINLKASKSMD 720

  Fly   665 FLPMSSPIY------SNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDY 723
            .:|..|.::      |..|:.  :.|..:|:..|:..:...:|.....|.    .|....|:|..
Human   721 LVPDESKVHSLAGQKSESPSK--DFGPTLGLKKSSSLESLQTAVAEVRKN----DLPFHRPRPHM 779

  Fly   724 FRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMY 788
            .|                |.|.|...:||       ..:||..|            ||.|.:.:.
Human   780 VR----------------GRGCNESFRAA-------IDKSYDGP------------EEIEADGLS 809

  Fly   789 PGYELNRYASVDCTALP------PPMEN---KVYGSAASSSSKSSGSSL---------------- 828
            .....:...:::|.:.|      ..|||   ||..:......|..|...
Human   810 DKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERK 874

  Fly   829 -------HQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAH------KNGQIHVGDQ 880
                   ..:.|..:.|.|||             |:.....|..||:..      |..:..:|.:
Human   875 IKKKGFGAMLRFGKKKEDKGG-------------KAEQKGTLKHGGLREEELEKMKEERERIGAK 926

  Fly   881 LLAIDEHSVQGMPLSHATSLLQNLGDLVD-------------------LKILRS----------- 915
            ...:.|...:|: |.:||..:.::.|:.|                   ..:.||
Human   927 HQELREKQARGL-LDYATGAIGSVYDMDDDEMDPNYARVNHFREPCTSANVFRSPSPPRAGPFGY 990

  Fly   916 ----HDLA-NGSHLPQTQAIYAKVQR-----------RPRSPSAN--TEASKESGSGNANGGGAV 962
                |.|: ...||   :.:||||.:           ||...|.:  .:..||.......|....
Human   991 PRDGHPLSPERDHL---EGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPLY 1052

  Fly   963 NGNSGSGKPRVFHVTLYKDKVYDDYGFSVS-DGLYERGVFINRIRSGGPAD 1012
            ..:.|..:|..:.:.....:..|....::. :|:..:...:.|   |||||
Human  1053 EDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPR---GGPAD 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	17/72 (24%)
		PDZ_signaling	183..254	CDD:238492	16/83 (19%)
		PDZ_signaling	278..375	CDD:238492	32/147 (22%)
		PDZ	496..>521	CDD:294084	4/24 (17%)
		PDZ_signaling	571..658	CDD:238492	25/127 (20%)
		PDZ_signaling	832..913	CDD:238492	18/105 (17%)
		PDZ_signaling	973..1055	CDD:238492	8/41 (20%)
PARD3B	XP_011508854.1	DUF3534	<44..151	CDD:288873	18/92 (20%)
		PDZ_signaling	209..296	CDD:238492	17/88 (19%)
		PDZ_signaling	395..475	CDD:238492	19/82 (23%)
		PDZ_signaling	509..597	CDD:238492	26/132 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900