DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and Il16

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_006229550.1 Gene:Il16 / 116996 RGDID:1583872 Length:1425 Species:Rattus norvegicus


Alignment Length:1233 Identity:248/1233 - (20%)
Similarity:405/1233 - (32%) Gaps:411/1233 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 SLNPV-GHAADF------LAPGDRLHQIDGISTIGL-SNQKVMNMLCAGGSDACPAIVEIEYSLP 166
            |:||. ....||      .||.||       ....| ||:|.::.             :::|.:.
  Rat   243 SVNPYSAREMDFPMTKKSAAPTDR-------QPYSLCSNRKSLSQ-------------QLDYPVS 287

  Fly   167 ECTVSQNSLCVTSKLAQIT-------------VERESGCLGLTLRGGAD--YPLIVTHVR---PH 213
            .......||. |::|.|::             ::.::..||.::.||.|  |..|..:|:   ..
  Rat   288 GTARPTRSLS-TAQLGQLSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKSIFAG 351

  Fly   214 GPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGP 278
            |.....||::.||.:|.::..|:.|.|..:|.|..|..  ..|...||:...::...|:...:.|
  Rat   352 GAAAADGRLQEGDEILELNGESIAGLTHQDALQKFKQA--KKGLLTLTVRTRLTTPPSLCSHLSP 414

  Fly   279 LLIEIERPMNDKLGLVLCN------YTAAVPASGSGSSTPSSGEKIEES---------------- 321
                   |:...|....|.      ::...|||.:.::.|:....:|.|                
  Rat   415 -------PLCRSLSSSTCGAQDSSPFSLESPASPASTAKPNYRIMVEVSLKKEAGVGLGIGLCSI 472

  Fly   322 ------AGVFIASILPASIADRCGALSVGDQVLSIDD------------TMIEHTAFSPDEVMTI 368
                  :||||.::.|.|:|...|.|..||:::.|:|            |::.|.  .|..|..|
  Rat   473 PYFQCISGVFIHTLSPGSVAHLDGRLRCGDEIVEINDSPVHCMTLNEVYTILSHC--DPGPVPII 535

  Fly   369 LDTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFS---------------TLESRK---SSTAG 415
            :........::.|:..|.|.|..| ...|..::.:|               |||..:   |:...
  Rat   536 VSRHPDPQVSEQQLKEAVAQAVEG-VKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKHSAPPH 599

  Fly   416 RQRQRFARKSSLP---LENPACGTPGSTGG----SMGTGGIHGSSSLGMGLGLCRAESFPVLLDC 473
            |:.|:...:||..   :.....|:|.|.|.    |.|.|..| |.||..|.   ..|..|.:...
  Rat   600 RRAQKIMVRSSSDSSYMSGSPGGSPCSAGAELQPSEGEGSTH-SPSLPPGE---EQEPCPGVPSR 660

  Fly   474 SHGAGIILSETVSGSG-------GSGAVAIAQIVPDS--------------------------VA 505
            .|.....|||::....       .|..:.:.:  |.|                          |.
  Rat   661 PHQESPPLSESLERDSHPPLKLKNSFEILVRK--PTSTKPKPPPRKYFKNDSEPQKKLEEKEKVT 723

  Fly   506 DRSG-----CIQAGDRIVAINKMYSLDAAAMRQLLEG-----------------GSSRNGASNGT 548
            |.||     |.|....::.:  :...|.|. |.|...                 |..|..||..|
  Rat   724 DPSGHTLPTCSQETRELLPL--LLQEDTAG-RTLCTAACCPGPAASTQTSSSTEGEPRRSASPET 785

  Fly   549 PAN---------WLELEIEFD---------MPDAVVPASGVFS---------VKLLRAGKCGLGL 586
            ||:         ...::..||         :.|.:   ..:||         :.|......|...
  Rat   786 PASPGKHPLLKRQARMDYSFDSTTEDPWVRISDCI---KNLFSPIMSENHSHMPLQPNASLGEED 847

  Fly   587 SVSGSSHGGLVISDVKMGSP---AHRSGSL-----------------------------RSGDIL 619
            ...|...|||...|...|:|   ....||.                             |:.::.
  Rat   848 GTQGHPEGGLSKMDTANGAPRIFKSADGSTVKKGPPVAPKPAWFRQSLKGLRNRVPETRRAPEVA 912

  Fly   620 LAVDQHPVQHFNVDALLKEEGRSQNPSHSS-----SDFTTLTIKRIVLPD-------FLPMSSPI 672
            .|:...||..   ||    .|.....|.||     |.|......:  |||       ..|.|...
  Rat   913 SAIQTTPVSR---DA----SGPQSQASSSSIRQRISSFENFGSSQ--LPDRGVQRLSLQPTSGET 968

  Fly   673 -----------YSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTP------- 719
                       :|..||.|..:   ......|:.:..|:.:..:.:..|....:|..|       
  Rat   969 TRLPGKQDEGRFSGLPAQGTKV---TAKHRQTEVEPPSTTFPNSSEVGDPDMSESPPPGQRPNPK 1030

  Fly   720 --QPD----------------YFRVPSMDDASL-----QSVQLRSGSGSNGGNQAANSWSTGVNS 761
              .||                .|::||....|.     ||.:.:.....:....:.:|..:....
  Rat  1031 ALSPDPLLRLLTTQTEDTQGPGFKMPSQRARSFPLTRTQSYETKLLDEKSSKLYSISSQLSSAVM 1095

  Fly   762 RSYVAPPNTQSL--TTELPEEE----------------DEQEQMYPGYELN-----RYASVDCTA 803
            :|.:..|::.|.  .|.:|:|.                .|......|:.||     .|:.    .
  Rat  1096 KSLLCLPSSASCGQITCIPKERVSPKSPCNNSAAAEGFGEAVASDTGFSLNLSELREYSE----G 1156

  Fly   804 LPPPMENKVYGSAASSSSKS-----SGSSLHQIIFTVRL------------------EPKGGLLG 845
            |..|.|.:.....:|.:.:|     |...|.::|..||:                  :.:|..||
  Rat  1157 LTEPGETEDRNHCSSQAGQSVISLLSAEELKKLIEEVRVLDEATLKQLDSIHVTVLHKEEGAGLG 1221

  Fly   846 ITLAGSEDI-TKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGD--- 906
            .:|||..|: .|.||:..:...|:|.:.|.|..|:::|:|:..|::|...:.|.::|:...|   
  Rat  1222 FSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGATHNDALAILRQARDPRQ 1286

  Fly   907 --LVDLKIL--RSHDLANGSHLPQTQAIYAKVQRRPRSPSANTEASKESGSGNANGGGAVNGNSG 967
              :|..|.:  .:|||                     :.|.::.||....||.         :..
  Rat  1287 AVIVTRKAIVEAAHDL---------------------NSSTDSAASASVASGI---------SVE 1321

  Fly   968 SGKPRVFHVTLYKDKVYDDYGFSVSDG---LY-ERGVFINRIRSGGPADMCGLLKPFDRIMQV 1026
            |.:..|..|||  :|.....|||:..|   |: ::.:.||||..|  .:....::|.|.|:|:
  Rat  1322 SVEATVCTVTL--EKTSAGLGFSLEGGKGSLHGDKPLTINRIFKG--TEQGDAVQPGDEILQL 1380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 13/44 (30%)
PDZ_signaling 183..254 CDD:238492 21/88 (24%)
PDZ_signaling 278..375 CDD:238492 28/136 (21%)
PDZ 496..>521 CDD:294084 8/55 (15%)
PDZ_signaling 571..658 CDD:238492 25/132 (19%)
PDZ_signaling 832..913 CDD:238492 27/104 (26%)
PDZ_signaling 973..1055 CDD:238492 19/58 (33%)
Il16XP_006229550.1 PDZ_signaling 316..391 CDD:238492 20/76 (26%)
PDZ_signaling 454..536 CDD:238492 19/83 (23%)
PDZ_signaling 1207..1284 CDD:238492 21/76 (28%)
PDZ 1329..1413 CDD:214570 18/56 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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