DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and PTPN21

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_008970.2 Gene:PTPN21 / 11099 HGNCID:9651 Length:1174 Species:Homo sapiens


Alignment Length:408 Identity:82/408 - (20%)
Similarity:130/408 - (31%) Gaps:135/408 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   610 SGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLP------M 668
            :|.:|:|.:..|...:.:.  |....|:....|.|||.:.||        ::.||:||      :
Human   386 NGRIRNGSVYSAHSTNSLN--NPQPYLQPSPMSSNPSITGSD--------VMRPDYLPSHRHSAV 440

  Fly   669 SSPIYSNCP---------ASGI-----------NLGMGMGVSTS-------TDHDLYSSAYVTAG 706
            ..|.|...|         ..|:           ||.:|...:.|       :..::...|.:.:.
Human   441 IPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSSYAYSRPAALVYSQPEIREHAQLPSP 505

  Fly   707 KYADC-----VSLKSRTPQP---------DYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWST 757
            ..|.|     .|..|.:|.|         ....||.:.:|.||:....|          .|...|
Human   506 AAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVPELTNAQLQAQDYPS----------PNIMRT 560

  Fly   758 GVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAAS--SS 820
            .|    |..||         |..........|....:.|.|   ::.|..:..:|:.|..:  ..
Human   561 QV----YRPPP---------PYPPPRPANSTPDLSRHLYIS---SSNPDLITRRVHHSVQTFQED 609

  Fly   821 SKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITK--SITISGLVEG--GIAHKN--------- 872
            |.....||.::     .||      :|.|....:.|  ||.::||..|  |:..|.         
Human   610 SLPVAHSLQEV-----SEP------LTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSASAAE 663

  Fly   873 ---GQIHVGDQLLAIDEHSVQGMP-------------LSHATSLLQNLGDLVDLKILRSHDLANG 921
               ..:.||.|.....|.:.:..|             ||.||.|:.:..:..|    ...:..:|
Human   664 VAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEED----EDFEEESG 724

  Fly   922 SHLPQTQAIYAKVQRRPR 939
            :..|..:|      |.||
Human   725 ARAPPARA------REPR 736

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492
PDZ 496..>521 CDD:294084
PDZ_signaling 571..658 CDD:238492 12/47 (26%)
PDZ_signaling 832..913 CDD:238492 23/109 (21%)
PDZ_signaling 973..1055 CDD:238492
PTPN21NP_008970.2 B41 24..222 CDD:214604
FERM_N 27..90 CDD:286467
FERM_M 109..220 CDD:278785
FERM_C_PTPN14_PTPN21 217..307 CDD:270009
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 396..445 14/58 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..692 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..745 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 769..806
PTPc 896..1166 CDD:214550
PTPc 923..1166 CDD:238006
Substrate binding. /evidence=ECO:0000250 1108..1114
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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