DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and PATJ

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_011538764.1	Gene:	PATJ / 10207	HGNCID:	28881	Length:	1937	Species:	Homo sapiens

Alignment Length:	880	Identity:	190/880 - (21%)
Similarity:	304/880 - (34%)	Gaps:	285/880 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 EIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGAD---YPLIVTHVRPHGPVYKTGR 221
            |.|.:..:..:.|....:..:|..|.:|::...|||:|.|..|   ..:.|..:.|.||....||
Human  1216 EEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGR 1280

  Fly   222 IKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERP 286
            ::.||.||.::|..|.|::...|..|||           |....|.:|          .|..|..
Human  1281 MRIGDELLEINNQILYGRSHQNASAIIK-----------TAPSKVKLV----------FIRNEDA 1324

  Fly   287 MNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSID 351
            :|.          .||......||:|||   ||:.:|.     .|.| ::..|::.||.:.|.
Human  1325 VNQ----------MAVTPFPVPSSSPSS---IEDQSGT-----EPIS-SEEDGSVEVGIKQLP-- 1368

  Fly   352 DTMIEHTAFSPDEVMTILDTSTGRGYT-----QMQIMPAHALARRGHTTLGSPKY----SFSTLE 407
                |..:|..:::..::    |:|..     .::..|.:|:::     :...||    |||:.|
Human  1369 ----ESESFKLEDMSQVI----GQGMVADQQKALEYPPDNAVSQ-----MKQQKYPTKVSFSSQE 1420

  Fly   408 SRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHGSSSL----------------- 455
                               :||. ||.....:.....|.||.....|:
Human  1421 -------------------IPLA-PASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEI 1465

  Fly   456 -----GMGLGLCRAESFPVLLDCSHG--------AGIILSETVSGSGGSGAVAIAQIVPDSVADR 507
                 |:||.:...:..|:.......        ...:|...|:...|..|:.|.::..:..|.|
Human  1466 SKGRSGLGLSIVGGKDTPLFWRLGSPRAWSQHLVRAFMLHHPVTEVEGQNAIVIHEVYEEGAAAR 1530

  Fly   508 SGCIQAGDRIVAINKMYSLDAAAMRQLLEGGSSRNG-------ASNGTP-----------ANWLE 554
            .|.:.|||:|:.:|               |...||.       |...||           |::.:
Human  1531 DGRLWAGDQILEVN---------------GVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRD 1580

  Fly   555 LE-IEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSHG-GLVISDVKMGSPAHRSGSLRSGD 617
            .| :|            :|.|.|.:....|||||:.|..:| |:.|||:..|..|...|.|..||
Human  1581 EENLE------------IFPVDLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGD 1633

  Fly   618 ILLAV---DQHPVQHFNVDALLK--------EEGR------------------SQNPSHSSSDFT 653
            .:|:|   |........|..:||        |.||                  ||..:|||..
Human  1634 QILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCH-- 1696

  Fly   654 TLTIKRIVLPDFLP-------------MSSPIYSN----------------CPASGINLGMGMGV 689
                     |.|.|             :|.|...|                ..|.||::..|.|
Human  1697 ---------PSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRG- 1751

  Fly   690 STSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANS 754
            |...|..::.:....:|..|....||...      |:.|::...|..:     |.::..|...|:
Human  1752 SPLGDIPVFIAMIQASGVAARTQKLKVGD------RIVSINGQPLDGL-----SHADVVNLLKNA 1805

  Fly   755 WSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYAS---VDCTALPPPMENKVYGSA 816
            :  |......||..|..::..:|       |.|..||.|....:   .:.|..|||.
Human  1806 Y--GRIILQVVADTNISAIAAQL-------ENMSTGYHLGSPTAEHHPEDTETPPPK-------- 1853

  Fly   817 ASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLA---GSEDITKSITISGLVEGGIAHKNGQIHVG 878
                           |.|:....:|  ||.::.   ||......|.:..:...|.|..:|::..|
Human  1854 ---------------IITLEKGSEG--LGFSIVGGYGSPHGDLPIYVKTVFAKGAAADDGRLKRG 1901

  Fly   879 DQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKIL 913
            ||:||::..:::|:....|.::|::....|.|.:|
Human  1902 DQILAVNGETLEGVTHEQAVAILKHQRGTVTLTVL 1936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084
		PDZ_signaling	183..254	CDD:238492	25/73 (34%)
		PDZ_signaling	278..375	CDD:238492	21/96 (22%)
		PDZ	496..>521	CDD:294084	8/24 (33%)
		PDZ_signaling	571..658	CDD:238492	34/116 (29%)
		PDZ_signaling	832..913	CDD:238492	21/83 (25%)
		PDZ_signaling	973..1055	CDD:238492
PATJ	XP_011538764.1	L27_2	8..65	CDD:117611
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	246..325	CDD:238492
		PDZ_signaling	366..450	CDD:238492
		PDZ_signaling	570..634	CDD:238492
		PDZ	683..772	CDD:214570
		PDZ_signaling	1066..1157	CDD:238492
		PDZ	1236..1321	CDD:214570	30/105 (29%)
		PDZ	1459..1574	CDD:214570	23/129 (18%)
		PDZ_signaling	1586..1666	CDD:238492	26/79 (33%)
		PDZ_signaling	1729..1814	CDD:238492	18/98 (18%)
		PDZ_signaling	1852..1936	CDD:238492	22/108 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810