DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and USH1C

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_016872564.1 Gene:USH1C / 10083 HGNCID:12597 Length:956 Species:Homo sapiens


Alignment Length:943 Identity:187/943 - (19%)
Similarity:321/943 - (34%) Gaps:262/943 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 HAADFLAPGD-----------RLHQIDGISTIGLSNQKVMN-----MLCAGGSDACPAIVEIEYS 164
            |..|||...|           ..||...::.:....:.|:|     .|........|...::||.
Human    11 HKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYD 75

  Fly   165 LPECTVSQNSLCVTSKLAQITVER--ESGCLGLTLRGGADY--PLIVTHVRPHGPVYKTGRIKPG 225
              :.|..:     :.||.::.::|  ..| |||::|||.::  .|.::|:...|.....| ::.|
Human    76 --QLTPRR-----SRKLKEVRLDRLHPEG-LGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVG 131

  Fly   226 DRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTN--------------LTIEY-DVSVVQS--VE 273
            |.::|::..|:...|..|...:|:....||....              ||.:| |..|.:|  |.
Human   132 DEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVR 196

  Fly   274 FSMGPLLIEIERPMN--DKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIAD 336
            .|:|       .|.|  :|...|   :.:.|.:.|.|.|. |||.  .:..|:||:.:.|.|::.
Human   197 GSLG-------SPGNRENKEKKV---FISLVGSRGLGCSI-SSGP--IQKPGIFISHVKPGSLSA 248

  Fly   337 RCGALSVGDQVL---SIDDTMIEHTAFSPDEVMTILDTSTG------------------------ 374
            ..| |.:|||::   .:|.:.::|     .|.:.:|.:|..                        
Human   249 EVG-LEIGDQIVEVNGVDFSNLDH-----KEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEA 307

  Fly   375 --RGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTP 437
              |...:.:::....||...:..|...:..........:..|..:.:|:.::....:|       
Human   308 RQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVE------- 365

  Fly   438 GSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGA--GIILSETVSGSGGSGAVAIAQIV 500
                                     ..|.|....:...|:  .::|.:|::          |::.
Human   366 -------------------------EEEKFKKQWEEDWGSKEQLLLPKTIT----------AEVH 395

  Fly   501 PDSVADRSGCIQAGDRIVAINK------MYSLDAAAMRQLLEGGSSRNGASNGT----PANWLEL 555
            |                |.:.|      .|..| .....:.:.|..:..|..|:    ..|..||
Human   396 P----------------VPLRKPKSFGWFYRYD-GKFPTIRKKGKDKKKAKYGSLQDLRKNKKEL 443

  Fly   556 EIE---FDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSHGGLVISDVKMGSPAHRSGSLRSGD 617
            |.|   :...:.::...     |.|:..:  |...||.:....|..|: |:.....|....|...
Human   444 EFEQKLYKEKEEMLEKE-----KQLKINR--LAQEVSETEREDLEESE-KIQYWVERLCQTRLEQ 500

  Fly   618 ILLAVDQ-------HPVQHFNVDALLKEEGRSQNPSH-SSSDFTTLTIKRIVLPDFLPMSSPIYS 674
            |..|.::       .|....:|..|.....|.....| .::|...:.:.....|...|.:.|:..
Human   501 ISSADNEISEMTTGPPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPVMP 565

  Fly   675 NCPASGIN--------LGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYF----RVP 727
            :.|.|...        |.:...||.|      ||.:|            .|||.|...    .||
Human   566 HPPPSNPPHKVPAPPVLPLSGHVSAS------SSPWV------------QRTPPPIPIPPPPSVP 612

  Fly   728 SMD-----------DASLQSVQLRSGSGSN------GGNQAANSWSTGVNSRSYVAPPNTQSLTT 775
            :.|           :.:|.:...|:|...|      ..|.:....::.|..:|:...|.|...:.
Human   613 TQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPKTFCPSP 677

  Fly   776 ELPE-------EEDEQEQMYPGYELNRYASVDCTALPPPMENK--VYGSAASSSSKSSGSSLHQI 831
            :.|.       .:.......|.: :.|.| |....||..|..:  ||.:|.....:.........
Human   678 QPPRGPGVSTISKPVMVHQEPNF-IYRPA-VKSEVLPQEMLKRMVVYQTAFRQDFRKYEEGFDPY 740

  Fly   832 -IFT--------VRL--EPKGGLLGITLAGSED--ITKSITISGLVEGGIAHKNGQIHVGDQLLA 883
             :||        |||  ..|.|.|.:.|.|..|  |.| :.:|.:.|.|.|.::|.|..||:::|
Human   741 SMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGK-VVVSAVYERGAAERHGGIVKGDEIMA 804

  Fly   884 IDEHSVQGMPLSHATSLLQNL----GDLVDLKI 912
            |:...|....|:.|.:.||..    ||.:||.:
Human   805 INGKIVTDYTLAEAEAALQKAWNQGGDWIDLVV 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 9/46 (20%)
PDZ_signaling 183..254 CDD:238492 19/74 (26%)
PDZ_signaling 278..375 CDD:238492 26/127 (20%)
PDZ 496..>521 CDD:294084 3/24 (13%)
PDZ_signaling 571..658 CDD:238492 18/94 (19%)
PDZ_signaling 832..913 CDD:238492 32/97 (33%)
PDZ_signaling 973..1055 CDD:238492
USH1CXP_016872564.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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