DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and grip1

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_031754780.1	Gene:	grip1 / 100485584	XenbaseID:	XB-GENE-853011	Length:	1143	Species:	Xenopus tropicalis

Alignment Length:	1287	Identity:	324/1287 - (25%)
Similarity:	480/1287 - (37%)	Gaps:	528/1287 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 RAMSPAQSEDSGLAPER--------GTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGH 116
            ::.:|:::.|..||..|        |:|...: :.:....|.:|.:...|....|.|.:|...|.
Frog    51 KSATPSKAPDGALAVRRQSITEEFKGSTIVEL-MKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGI 114

  Fly   117 AA--DFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTS 179
            ||  |.|..||.:..::||:.....:.:::::|...|.   ..::|:||.||  .||.....|..
Frog   115 AARSDQLNVGDYIKAVNGINLTKFRHDEIISLLKNVGE---RVVLEVEYELP--PVSIQGTGVIF 174

  Fly   180 KLAQITVERESGCLGLTLRGGA------DYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIG 238
            |..::|:.:|....|..:||||      ..|:::|.|||.||..:.|.||||||||.||.:.|.|
Frog   175 KTVEVTLHKEGNTFGFVIRGGAHEDRNKSRPIVITCVRPGGPADREGTIKPGDRLLSVDGIRLHG 239

  Fly   239 KTLAEAQQIIK-CGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCN---YT 299
            .|.|||..|:| ||...:    |.|||||||:.:|..:.||||:|:.:.....||:.|..   |.
Frog   240 TTHAEAMSILKQCGQEAT----LLIEYDVSVMDTVSSASGPLLVEVAKTPGSNLGVALTTSMYYN 300

  Fly   300 AAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDE 364
            ..|                     :.|..|..||||||||||.:||.:||:|.|.:|:...:.
Frog   301 KQV---------------------IVIDKIKSASIADRCGALHIGDHILSVDGTSMEYCTLAE-- 342

  Fly   365 VMTILDTSTGRGYTQMQIMPAH--ALARRG-------------------------------HTTL 396
             .|.|..||.. :.:::|:|.|  .||.:|                               :.|.
Frog   343 -ATQLLASTSE-HVKLEILPYHQTRLALKGPDHVKVQRSNDRQPPRNFSANSHSRLPTCQHYNTY 405

  Fly   397 GSPKY----------------------SFS-------TLESRKSSTAGR-----------QRQRF 421
            ..|.:                      |||       :|.|..:.|..|           .|:|.
Frog   406 HHPDHCRTPAMKCQKPPPQKLLPLVSSSFSPTSMSAYSLSSLNTGTLPRSLYPTSPRGTLMRRRM 470

  Fly   422 AR---KSSLPLENPACGTPGSTGGSMGTGGIHGSSS---------LGMGLGLCRAESFPVLLDCS 474
            .:   ||||.|.:...|..|..        :|..|:         ||.|:.|
Frog   471 KKKDFKSSLSLASSTVGLAGQV--------VHTESTEVVLTADPVLGFGIQL------------- 514

  Fly   475 HGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAA--AMRQLLEG 537
             ...:..:||:     |....|:.|..||.|:|.|.:|.|||::|||.:.:.|:.  ...|||.
Frog   515 -QGSVFATETL-----SSPPLISYIDADSPAERCGILQVGDRVIAINGVQTEDSTFEEANQLLR- 572

  Fly   538 GSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSS----HGGLVI 598
                    :.|.|..:.||||||:.::|:|:||.|.|||.:.....||:::|..|    ...|||
Frog   573 --------DSTIAGKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSTRKTGDPLVI 629

  Fly   599 SDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLP 663
            ||:|.||.|||:|:|..||.|||:|     :..:|
Frog   630 SDIKKGSVAHRTGTLELGDKLLAID-----NIRLD------------------------------ 659

  Fly   664 DFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPS 728
                       ||                                                   |
Frog   660 -----------NC---------------------------------------------------S 662

  Fly   729 MDDA--SLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGY 791
            |:||  .||..:                                :.:..::.::||.
Frog   663 MEDAVQILQQCE--------------------------------ELVKLKIRKDEDN-------- 687

  Fly   792 ELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITK 856
                                      |...:|||:    ||:||.|:..||.||||::|:|:...
Frog   688 --------------------------SDEQESSGA----IIYTVELKRYGGPLGITISGTEEPFD 722

  Fly   857 SITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILR------- 914
            .|.||.|.:||:|.:.|.||:||::|||:.:|::|.|||.|..|||..|:.|.|||.:
Frog   723 PIIISSLTKGGLAERTGAIHIGDRILAINSNSLKGKPLSEAIHLLQMAGETVTLKIKKQTDATSP 787

  Fly   915 -----------------------------------------------SHDLANGSHLPQTQA--- 929
                                                           :.|.|.||..|..||
Frog   788 KLSSGRISELCDAEDETPVTQKSSNLSDIYSTAVPSVDSAVESWDGSAADTAYGSQGPNFQASGF 852

  Fly   930 -IYAKVQRRPR-----SP----------------------------------------------- 941
             ..|...|.|:     ||
Frog   853 SFNAYEWRNPKQKGSLSPLNRPRNNHFHDTGLSDDEWDRPTTSGYTGGPEGPDGEQEENFWSQAL 917

  Fly   942 -----------------SANTEASKESGS------GNANGGGAVNGNS-----GSGKP------- 971
                             .|.::|:..|||      .|:...|.:...:     .||:|
Frog   918 EDLETCGQSGILRELEEKAGSQATIMSGSTLSLNHENSQPRGQLGRQASFQEKSSGRPHYSQSIR 982

  Fly   972 -------------------------------RVFHVTLYKDKVYDDYGFSVSDGLYERGVFINRI 1005
                                           .:..|:|:||...:|:||||:|||.|:||::..|
Frog   983 SNTLPSDVGRKSVSMRKIKQEIKDIMSPTPVELHKVSLFKDSDREDFGFSVADGLLEKGVYVKNI 1047

  Fly  1006 RSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQRS 1057
            |..||.|:.| |||:||::|||.::|:||||||.|||||.:|:|:|:::.|:
Frog  1048 RPNGPGDIAG-LKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLELVISRN 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	15/66 (23%)
		PDZ_signaling	183..254	CDD:238492	35/77 (45%)
		PDZ_signaling	278..375	CDD:238492	32/99 (32%)
		PDZ	496..>521	CDD:294084	12/24 (50%)
		PDZ_signaling	571..658	CDD:238492	28/90 (31%)
		PDZ_signaling	832..913	CDD:238492	40/80 (50%)
		PDZ_signaling	973..1055	CDD:238492	44/81 (54%)
grip1	XP_031754780.1	PDZ_signaling	80..159	CDD:238492	18/82 (22%)
		PDZ_signaling	178..261	CDD:238492	36/86 (42%)
		PDZ_signaling	276..359	CDD:238492	32/107 (30%)
		PDZ_signaling	499..585	CDD:238492	29/113 (26%)
		PDZ_signaling	598..682	CDD:238492	36/212 (17%)
		PDZ_signaling	698..779	CDD:238492	40/80 (50%)
		PDZ_signaling	1015..1095	CDD:238492	44/80 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6631
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2500
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42090at33208
OrthoFinder	1	1.000	-	-		FOG0003379
OrthoInspector	1	1.000	-	-		otm49274
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2278
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060