DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUXA and zfh1

DIOPT Version :9

Sequence 1:	NP_001012747.1	Gene:	DUXA / 503835	HGNCID:	32179	Length:	204	Species:	Homo sapiens
Sequence 2:	NP_733401.3	Gene:	zfh1 / 43650	FlyBaseID:	FBgn0004606	Length:	1206	Species:	Drosophila melanogaster

Alignment Length:	145	Identity:	37/145 - (25%)
Similarity:	61/145 - (42%)	Gaps:	23/145 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    46 QKLALEINTEESRIQIWFQNRRARHGFQKRPEAETLESSQSQGQDQPGVEFQSREARRCRTTYSA 110
            :|:...:..||  ::..||.::|..........|..|..:...:::|..|...|:. |.||..:.
  Fly   647 EKVLCGLIKEE--LEQHFQQQQATSFALASASEEDEEDEEMDVEEEPRQESGERKV-RVRTAINE 708

Human   111 SQLHTLIKAFMKNPYPGIDSREELAKEIGVPESRVQIWFQNRRSRLLLQRKRE------------ 163
            .|...|.:.:..|..|..|....:|..:.:....||:||||.|||   :||.:
  Fly   709 EQQQQLKQHYSLNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSR---ERKMQSFQNNQAAGAAP 770

Human   164 --PV---ASLEQEEQ 173
              |:   |||.:|:|
  Fly   771 PMPIDSQASLTREDQ 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUXA	NP_001012747.1	homeodomain	16..74	CDD:238039	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..101		5/27 (19%)
		Homeobox	105..155	CDD:278475	15/49 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..204		6/28 (21%)
zfh1	NP_733401.3	C2H2 Zn finger	291..311	CDD:275368
		C2H2 Zn finger	326..346	CDD:275368
		zf-C2H2	355..377	CDD:278523
		C2H2 Zn finger	357..377	CDD:275368
		zf-H2C2_2	369..391	CDD:290200
		Homeobox	703..755	CDD:278475	17/54 (31%)
		C2H2 Zn finger	969..989	CDD:275368
		zf-H2C2_2	981..1006	CDD:290200
		COG5048	992..>1045	CDD:227381
		C2H2 Zn finger	997..1017	CDD:275368
		zf-H2C2_2	1009..1034	CDD:290200
		C2H2 Zn finger	1025..1042	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910