Protein Alignment Dora and ZSWIM5

DIOPT Version :10

• Sequence 1: NP_001356949.1
• Gene: Dora / 50356
• FlyBaseID: FBgn0085430
• Length: 2371
• Species: Drosophila melanogaster
• Sequence 2: NP_065934.1
• Gene: ZSWIM5 / 57643
• HGNCID: 29299
• Length: 1185
• Species: Homo sapiens
• Alignment Length: 1469
• Identity: 329/1469 - (22%)
• Similarity: 489/1469 - (33%)
• Gaps: 523/1469 - (35%)

  Fly    18 CSWSSEPESLCNNWRGWKKPAAGSGAGNGGLSGMGGMAVAGGSGAPPFGGAGASGSCTPGGNGTA 82
            |||.| |::        ..|....||..||..|:|...:.  .||.|
Human    23 CSWPS-PQA--------HHPRGSPGAAGGGAGGVGSSCLV--LGARP------------------ 58

  Fly    83 MANTSTCGRHYEVSTLAELAARCVASYIPFELVEHVYPPVPEQLQLRIAFWSFPDNEEDIRLYS- 146
                     |.:..:|.:.||:.||....:|.||..:..:||.:|.||.:||||.||.:|.:||
Human    59 ---------HLQPDSLLDCAAKTVAEKWAYERVEERFERIPEPVQRRIVYWSFPRNEREICMYSS 114

  Fly   147 --------------CLANSSADE------------------------------------------ 155
                          ....|.|:|
Human   115 FQYRGGPGAGAAGGAAGASPAEEGPQPPPGAAAPAGSAPGGVAAGASPGLGAGAGAAGCGGEGLP 179

  Fly   156 FNRGDSLFRLRAVKDPLQIGFHLSASVVN----QTPRAYFNVAVTFDRRRISSCNCTC-TSSAYW 215
            |.||..|....:|::.||:|||||.:|..    ..|...:.||::|||.:|:|..|.| ....::
Human   180 FRRGIRLLDSGSVENVLQVGFHLSGTVTELATASEPAVTYKVAISFDRCKITSVTCGCGNKDIFY 244

  Fly   216 CSHVVAVCLHRIHCPQEVCLRAPVSESLTRLQRDQLQKFAQYLISELPQQILPTAQRLLDELLSA 280
            |:||||:.|:||..|.:|.||.|:||:|.::.|||||||.||||:....::|||||:|.||:||:
Human   245 CAHVVALSLYRIRKPDQVKLRLPISETLFQMNRDQLQKFIQYLITAHHTEVLPTAQKLADEILSS 309

  Fly   281 QPTAINTVCGAPDPTAGASINDQTSWYLDEKTLHNNIKRILIKFCLPAPIVFSDVNYLTNSAPPA 345
            . :.||.|.|||||||||||:|:..|:|||:.:...:|..|           |...|..:
Human   310 N-SEINQVNGAPDPTAGASIDDENCWHLDEEQVKEQVKLFL-----------SQGGYCGS----- 357

  Fly   346 AAEWSSLLRPLRGREPEGMWNLLSIVREMYRRCDRNAVRLLEIITEECLYCDQILIWWFQTKLAL 410
                        |::...|:   :.||||.|..|.|..|:|.:|||:.:...::.:|
Human   358 ------------GKQLNSMF---AKVREMLRMRDSNGARMLTLITEQFVADPRLTLW-------- 399

  Fly   411 MMGSHGHSGGKHSNTHSNSTALQHACSSLCDEIVALWRLAALNPGLAPDERDMLHAQFTAWHLKI 475
                           ....|.:...|..|.||:.|||....|||....:|:.....|...|
Human   400 ---------------RQQGTNMTDKCRQLWDELGALWVCIILNPHCKLEEKSCWLQQLQKW---- 445

  Fly   476 LDRVVKSRMMPSYTNKHQQNSRSETELFIGFKPAIEACYLDWEGYPIPGVTHTHDTNPIYYSPFT 540
                                  |:.::.    |..:..|    |:.:|.:|:....:.| :||
Human   446 ----------------------SDLDVC----PLEDGNY----GHELPNITNALPQSAI-HSP-- 477

  Fly   541 CFKHTDLKGESNNPGQLNATQALMSNNKHYNYFSSSSDHGMHAGAFKQRLDRPFRESRFYTNPAD 605
                    ...:.|.:...|:|:.....|:.            .:..||:    ..|..||.||
Human   478 --------DSLSRPRRTVFTRAIEGRELHWQ------------DSHLQRI----ISSDVYTAPA- 517

  Fly   606 LDGGAALAGGGSGRFSTGLGSVAVGGAGAGGLGQMSGGVNNSVGGSAAAEVNPV-QQQLPSGSAG 669
                       ..|.|..|                   :.||.|       .|: .:.:|:..|.
Human   518 -----------CQRESERL-------------------LFNSQG-------QPLWLEHVPTACAR 545

  Fly   670 VGASVTNAKVVVATDGNRSSASSEGFCENDDFGGDTSSSHNYCPPGQAVVPGQKSALTES----- 729
            |                                 |...||.|        |.:...||.:
Human   546 V---------------------------------DALRSHGY--------PKEALRLTVAIINTL 569

  Fly   730 --DSQSSFDAVSHQSKDEPPVGGVGVA-----VG------------VEQALSTSDTSSASSSSSS 775
              ..|...:...||.|:....|...:.     ||            :.:|...:|......|..:
Human   570 RLQQQRQLEIYKHQKKELLQRGTTTITNLEGWVGHPLDPIDCLFLTLTEACRLNDDGYLEMSDMN 634

  Fly   776 AS---------TASGSSNSSTSSMLMAGQEATVGVG-------GAVQQTTRRLSKDESFS----- 819
            .|         .|:||.|||.|.:.:|.:.|.:|:|       |...|.....::::..|
Human   635 ESRPPVYQHVPVAAGSPNSSESYLSLALEVALMGLGQQRLMPEGLYAQDKVCRNEEQLLSQLQEL 699

  Fly   820 SSSDEFNQGGVGGSAGR--VAMASSGSGSGAGDTVAVGSGSTAGGDLTPVPSTSAAARAALAASS 882
            ...||..|     :..:  :.:...|..||.|:.:...|        .|:.:.:....:||.
Human   700 QLDDELVQ-----TLQKQCILLLEGGPFSGLGEVIHRES--------VPMHTFAKYLFSALL--- 748

  Fly   883 TGPVISASPHLAASAAGGLGVLGVGADQPCTSSAHAARALA------AAVAASSDKPHVFSNVRP 941
                    ||                 .|..|...|.||:.      :|.|..:..||...:|.|
Human   749 --------PH-----------------DPDLSYKLALRAMRLPVLENSASAGDTSHPHHMVSVVP 788

  Fly   942 TE-DAWDILLARAEGLHAHGH-GAEACILAVRLAEQMLANPPNLLLELPPAPKRKGKKQNVNPIS 1004
            :. ..|..|          || .::.|.||                                  |
Human   789 SRYPRWFTL----------GHLESQQCELA----------------------------------S 809

  Fly  1005 HQLTVVASATLSKCAFLCTVLSENSEHYH---IGFRICLFALEMPRPPASTKPLEVKLANQEADI 1066
            ..||.....||.    |.|:|....:|.|   :.|::...|.::..|..|:           .|.
Human   810 TMLTAAKGDTLR----LRTILEAIQKHIHSSSLIFKLAQDAFKIATPTDSS-----------TDS 859

  Fly  1067 LALLKRLPLGSAELQVIRERAEQLRSGTFKTRGEALLPINLATFI-FDALVTLSPLGGSTIVPGV 1130
            ..|...|.||   |||:|.....|   .::.|......:..||.: ..|||::.....:...|
Human   860 TLLNVALELG---LQVMRMTLSTL---NWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTP-- 916

  Fly  1131 ASTSGVSSAAGKSMVNTGTRLLLYKHNSDESLGFDAAVAAL----------GLKA-NVSEAEHPL 1184
              |...|..|..::.:|....|...:...|.|...|...||          .|.| .:.|.:| :
Human   917 --TEATSIVAATAVSHTTILRLSLDYPQREELASCARTLALQCAMKDPQSCALSALTLCEKDH-I 978

  Fly  1185 LCEGTRRQRGDLALTLLSHYKDEPRKIAKIME----KLLDRDIHTLLNAPLLPAYYSSNPPVRTR 1245
            ..|...:...|.|...::|  .:...||:.||    .|....:.:|..:.|..||
Human   979 AFEAAYQIAIDAAAGGMTH--SQLFTIARYMELRGYPLRAFKLASLAMSHLNLAY---------- 1031

  Fly  1246 SNQPTRREDHDYGGGSGCASSNCNPVANLCELLPADYGSVGGNSRPHSSTSAELELSMCALSMAS 1310
             ||.|....:|...  .||.|:......|..|:|....||      |.:|.....|..|
Human  1032 -NQDTHPAINDVLW--ACALSHSLGKNELAALIPLVVKSV------HCATVLSDILRRC------ 1081

  Fly  1311 SGSQSGGVQGMVPTTNAAGTTGTPS--SSSTTVSGSQNP 1347
                         |..|.|..|.|.  ||...:|..:.|
Human  1082 -------------TVTAPGLAGIPGRRSSGKLMSTDKAP 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dora	NP_001356949.1	SWIM	138..>276	CDD:443750	64/199 (32%)
ZSWIM5	NP_065934.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		10/30 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	123..153		3/29 (10%)
		SWIM	180..>291	CDD:443750	50/110 (45%)