DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34401 and Zswim8

DIOPT Version :9

Sequence 1:	NP_001356949.1	Gene:	CG34401 / 50356	FlyBaseID:	FBgn0085430	Length:	2371	Species:	Drosophila melanogaster
Sequence 2:	XP_006519097.1	Gene:	Zswim8 / 268721	MGIID:	1919156	Length:	1904	Species:	Mus musculus

Alignment Length:	2101	Identity:	815/2101 - (38%)
Similarity:	1028/2101 - (48%)	Gaps:	520/2101 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DRFSFDDSIRFEEDSLCSWSSEPESLCNNWRGWKKPAAGSGAGNGGLSGMGGMAVAGGSGAPPFG 66
            :||||:||.|||||||||:.||.||||.|||||:|.:||..:                    |.|
Mouse    12 ERFSFEDSDRFEEDSLCSFISEAESLCQNWRGWRKQSAGPNS--------------------PTG 56

  Fly    67 GAGASGSCTPGGNGTAMANTSTCGRHYEVSTLAELAARCVASYIPFELVEHVYPPVPEQLQLRIA 131
            |.|..||   ||..|         |...|..|.||:|:.||.:||||:||.||||||||||||||
Mouse    57 GGGGGGS---GGTRT---------RDGLVIPLVELSAKQVAFHIPFEVVEKVYPPVPEQLQLRIA 109

  Fly   132 FWSFPDNEEDIRLYSCLANSSADEFNRGDSLFRLRAVKDPLQIGFHLSASVVNQ---TPRAYFNV 193
            |||||:|||||||||||||.|||||.|||.|||:|||||||||||||||:||..   .|:..:||
Mouse   110 FWSFPENEEDIRLYSCLANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVVPPQMVPPKGAYNV 174

  Fly   194 AVTFDRRRISSCNCTCTSSAYWCSHVVAVCLHRIHCPQEVCLRAPVSESLTRLQRDQLQKFAQYL 258
            ||.|||.|::||:|||.:.|.||:||||:||.|||....|||||||||||:||||||||||||||
Mouse   175 AVMFDRCRVTSCSCTCGAGAKWCTHVVALCLFRIHNASAVCLRAPVSESLSRLQRDQLQKFAQYL 239

  Fly   259 ISELPQQILPTAQRLLDELLSAQPTAINTVCGAPDPTAGASINDQTSWYLDEKTLHNNIKRILIK 323
            |||||||||||||||||||||:|.|||||||||||||||.|.:||::|||||.||.:|||:.|.|
Mouse   240 ISELPQQILPTAQRLLDELLSSQSTAINTVCGAPDPTAGPSASDQSTWYLDESTLTDNIKKTLHK 304

  Fly   324 FCLPAPIVFSDVN--YLTNSAPPAAAEWSSLLRPLRGREPEGMWNLLSIVREMYRRCDRNAVRLL 386
            ||.|:|:||||||  ||:::.|||||||:.||||||||||||:||||||||||::|.|.||..||
Mouse   305 FCGPSPVVFSDVNSMYLSSTEPPAAAEWACLLRPLRGREPEGVWNLLSIVREMFKRRDSNAAPLL 369

  Fly   387 EIITEECLYCDQILIWWFQTKLALMMGSHGHSGGKHSNTHSNSTALQHACSSLCDEIVALWRLAA 451
            ||:|::||..:||..||:..:.:   .||..:.|....::..|....|||:|:|||:|.|||||.
Mouse   370 EILTDQCLTYEQITGWWYSVRTS---ASHSSASGHTGRSNGQSEVAAHACASMCDEMVTLWRLAV 431

  Fly   452 LNPGLAPDERDMLHAQFTAWHLKILDRVVKSRMMPSYTNKHQQNSRSETELFIGFKPAIEACYLD 516
            |:|.|:|..|..|.||...|.||:::.|           |..|:.::...||.||:||:||||.:
Mouse   432 LDPALSPQRRRELCAQLRQWQLKVIENV-----------KRGQHKKTLERLFPGFRPAVEACYFN 485

  Fly   517 W-EGYPIPGVTHTHDTNPIYYSPFTCFKHTDLKGESNNPGQLNATQALMSNNKHYNYFSSSSDHG 580
            | |.||:||||::.....:    ..|:    .:.....||                        .
Mouse   486 WEEAYPLPGVTYSGTDRKL----ALCW----ARALPARPG------------------------A 518

  Fly   581 MHAGAFKQRLDRPFRESRFYTNPA--DLDGGAALAGGGSG--------RFSTGLGSVA------- 628
            ..:|..::...||..     |.||  ..:.||...|.|.|        |.|...|..|
Mouse   519 SRSGGLEESRPRPLP-----TEPAVRPKEPGAKRKGLGEGISSQRGPRRLSAEGGDKALHKMGPS 578

  Fly   629 ------VGGAGAGGLGQMSGGVNNSVGG-SAAAEVNPVQQQLPSGSAGVGASVTNAKVVVATDGN 686
                  :||.|:||......|....:.. .::.|.:..:..|...|..:||
Mouse   579 GGKAKVLGGTGSGGKSSAGSGSKRRLSSEDSSLEPDLAEMSLDDSSLALGA-------------- 629

  Fly   687 RSSASSEGFCENDDFGGDTSSSHNYCPPGQAVV--PGQKSALTESDSQSSFDA-VSHQSKDEPPV 748
                      |...|||...|.    ||..:.|  .|..:.|.|.......|| |......|||.
Mouse   630 ----------EASTFGGFPESP----PPCPSSVGSRGPSTFLPEPPDTYEEDAGVYFSEGPEPPT 680

  Fly   749 GGV---GVAVGV----EQALSTSDTSSASSSSSSASTASGSSNSSTSSMLMAGQEATVGVGGAVQ 806
            ...   |:..|.    :...||.|:.|....:..|:.|.|..:....:..:..|:   |.||
Mouse   681 ASADHPGLLPGEVCTRDDLPSTDDSGSGLHKTKEAAPAVGEEDDDYQAYYLNAQD---GAGG--- 739

  Fly   807 QTTRRLSKDESFSSSSDEFNQGGVGGSAGRVAMASSGSGSGAGDTVAVGSGSTAGGDLTPVPSTS 871
                           .:|..:||.|
Mouse   740 ---------------EEEKAEGGTG---------------------------------------- 749

  Fly   872 AAARAALAASSTGPVISASPHLAASAAGGLGVLGVGADQPCTSSAHAARALAAAVAASSDKPHVF 936
                                                                       ::..:|
Mouse   750 -----------------------------------------------------------EEHDLF 755

  Fly   937 SNVRP--TEDAWDILLARAEGLHAHGHGAEACILAVRLAEQMLANPPNLLLELPPAPKRKGKKQN 999
            :.::|  .|...::|.|.||.|||||:..||..|.|.||:.:|||||:|.:|.|||   ||||..
Mouse   756 AGLKPLEQESRMEVLFACAEALHAHGYSNEASRLTVELAQDLLANPPDLKVEPPPA---KGKKNK 817

  Fly  1000 VNPISHQLTVVASATLSKCAFLCTVLSENSEHYHIGFRICLFALEMPRPPASTKPLEVKLANQEA 1064
            |:  :.:.|.||:.||:|.|||.|||||..||:.:.||:.:||||:.|||||||.||||||.||:
Mouse   818 VS--TSRQTWVATNTLTKAAFLLTVLSERPEHHSLAFRVGMFALELQRPPASTKALEVKLAYQES 880

  Fly  1065 DILALLKRLPLGSAELQVIRERAEQLRSGTFKTRGEALLPINLATFIFDALVTLSPLGGSTIVPG 1129
            ::.||||::|.|.:|:..||.|||:||.||. .....:||:.||:||||.|  .:|
Mouse   881 EVAALLKKIPRGPSEMSTIRCRAEELREGTL-CDYRPVLPLMLASFIFDVL--CAP--------- 933

  Fly  1130 VASTSGVSSAAGKSMVNTGTRLLLYKHNSDESLGFDAAVAALGLKANVSEAEHPLLCEGTRRQRG 1194
            |.|.:| |....::..|        :...||.|||:|||||||:|..|||||||||||||||::|
Mouse   934 VVSLTG-SRPPSRNWTN--------EMPGDEELGFEAAVAALGMKTTVSEAEHPLLCEGTRREKG 989

  Fly  1195 DLALTLLSHYKDEPRKIAKIMEKLLDRDIHTLLNAP-LLPAYYSSNPPVRTRSNQPTRREDHDYG 1258
            ||||.|:..|||:..|:.||::|||||:..|  :.| .|.::|||:.|.......|::.
Mouse   990 DLALALMITYKDDQAKLKKILDKLLDRESQT--HKPQTLSSFYSSSRPATANQRSPSKH------ 1046

  Fly  1259 GGSGCASSNCNPVANLCELLPADYGSVGG---------------NSRPHSSTSAELELSMCALSM 1308
             |:..|.....|:.: ....||..|:|.|               .|.|||...          .:
Mouse  1047 -GAPSAPGALQPLTS-SSAGPAQPGNVAGAGPGPTEGFTEKNVPESSPHSPCE----------GL 1099

  Fly  1309 ASSGSQSGGVQGMVPTTNAAGTTG-----------------------------TPSSSSTTVS-- 1342
            ....:.:...:|.||:..|.|:.|                             |.|.||.|:|
Mouse  1100 PPEAALTPRPEGKVPSRLALGSRGGYNGRGWGSPGRPKKKHTGMASIDSSAPETTSDSSPTLSRR 1164

  Fly  1343 -----------GSQNPNGNPSGSGGGGNGGGGNGGGGGGGGGGGGSTSSRSKESRYKGKRA---Y 1393
                       |....:.:.|.|.....|...:.|.......||....:......|||:|.   .
Mouse  1165 PLRGGWAPTSWGRGQDSDSISSSSSDSLGSSSSSGSRRASASGGARAKTVDVGRCYKGRRPESHA 1229

  Fly  1394 PSIPNQPSEASAHFMFELAKNVLTKAGGNSSTSLFTQASTSQNHHGPHRALHMCAFQLGLYALGL 1458
            |.:|||||||:|||.|||||.||.|||||||||:||..|:|..|.||||.||:|||::|||||||
Mouse  1230 PHVPNQPSEAAAHFYFELAKTVLIKAGGNSSTSIFTHPSSSGGHQGPHRNLHLCAFEIGLYALGL 1294

  Fly  1459 HNCVSPNWLSRTYSSHVSWILGQAMEIGAPAISFLIDTWEAHLTPPEAAGMADRASRGWDSNMVY 1523
            ||.|||||||||||||||||.|||||||:.|::.|::.|:.||||||.|.:||||||..|||||.
Mouse  1295 HNFVSPNWLSRTYSSHVSWITGQAMEIGSAALTILVECWDGHLTPPEVASLADRASRARDSNMVR 1359

  Fly  1524 PAAELALSVLPHAAALNPNEIQRAILQCKEQSDLMLERACLTVETAAKGGGVYPEVLFQVARYWY 1588
            .|||||||.||||.||||||||||::|||||.:||||:||:.||.|||||||||||||:||..|:
Mouse  1360 AAAELALSCLPHAHALNPNEIQRALVQCKEQDNLMLEKACMAVEEAAKGGGVYPEVLFEVAHQWF 1424

  Fly  1589 ELYMRNTPNNSEFEPHDDTMDHSAVSLSALIESQQQHELQQQQQAVQQQQAVQQQQQVVQQQQQV 1653
            .||......:|       |....|.|.|.
Mouse  1425 WLYEETAGGSS-------TAREGATSCSG------------------------------------ 1446

  Fly  1654 VQQQQQLGMPNSVVPGGVGPGPGL-PVAVQPPVVGSVQNPQAQFQPVGVASLAP---LGLAQYPP 1714
             ...:..|.....:|.|.| .||. ||.|....|            ...|::.|   :|.:.||.
Mouse  1447 -SGMRAAGEAGRGLPEGRG-APGTEPVTVAAAAV------------TAAATVVPVISVGSSLYPG 1497

  Fly  1715 YSFCQGLYAHHHNMSYPPGQMQMFISAGPPPPPQAYGGYQQPPPQQPPNPQQQQQVVQQQVQQQQ 1779
                .|| .|.|:....|                    |....|..|.:||
Mouse  1498 ----PGL-GHGHSPGLHP--------------------YTALQPHLPCSPQ-------------- 1523

  Fly  1780 VVQQQQQQVQMAGQAPPGHPGQQGHPGQP-----PSGFQPQPPPGAF------QALPPQAYQAMQ 1833
                     .:...|.|.||  ..|..:|     ||...||....||      .::.|.:..|..
Mouse  1524 ---------YLTHPAHPAHP--MPHMPRPAVFPVPSSAYPQGVHPAFLGAQYPYSVTPPSLAATA 1577

  Fly  1834 AGPPGPPMGP--PQGYYGPPPPPPPNGPPGVGVGVGVGVGVGVMPMRQHQHQHPVYPFMQQAPPQ 1896
            ...|.|.|.|  ...|:..|..|.|........|.|....|         |....:|.:|.| ..
Mouse  1578 VSFPVPSMAPITVHPYHTEPGLPLPTSVACEFRGQGAVSSV---------HPASTFPAIQGA-SL 1632

  Fly  1897 PPQQQQPPP-----SQPPVRQRQPHQFTPTQLRYLLAAYNVGMLAMETLARRVHDDRPQAKYARN 1956
            |....||.|     ..||..:.......|..|.:|.|||.|||||:|.|.||.|:|.|. .::|:
Mouse  1633 PALTTQPSPLVSGGFPPPEEETHSQPVNPHSLHHLHAAYRVGMLALEMLGRRAHNDHPN-NFSRS 1696

  Fly  1957 PPYGEDVKWLLRISKKLGTQY 1977
            |||.:||||||.::.|||.::
Mouse  1697 PPYTDDVKWLLGLAAKLGDRH 1717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34401	NP_001356949.1	None
Zswim8	XP_006519097.1	Treacle	1016..>1158	CDD:367557	29/161 (18%)
Zswim8	XP_006519097.1	Atrophin-1	<1491..>1661	CDD:367360	48/229 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850239
Domainoid	1	1.000	1092	1.000	Domainoid score	I21
eggNOG	1	0.900	-	-		E1_KOG3615
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1356	1.000	Inparanoid score	I136
Isobase	1	0.950	-	0	Normalized mean entropy	S6885
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006333
OrthoInspector	1	1.000	-	-		oto93101
orthoMCL	1	0.900	-	-		OOG6_107078
Panther	1	1.100	-	-	LDO	PTHR22619
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3876
SonicParanoid	1	1.000	-	-		X4608
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.820