Protein Alignment CG34401 and ZSWIM8

DIOPT Version :9

• Sequence 1: NP_001356949.1
• Gene: CG34401 / 50356
• FlyBaseID: FBgn0085430
• Length: 2371
• Species: Drosophila melanogaster
• Sequence 2: XP_005269705.1
• Gene: ZSWIM8 / 23053
• HGNCID: 23528
• Length: 1905
• Species: Homo sapiens
• Alignment Length: 2104
• Identity: 827/2104 - (39%)
• Similarity: 1039/2104 - (49%)
• Gaps: 524/2104 - (24%)

  Fly     2 DRFSFDDSIRFEEDSLCSWSSEPESLCNNWRGWKKPAAGSGAGNGGLSGMGGMAVAGGSGAPPFG 66
            :||||:||.|||||||||:.||.||||.|||||:|.:||..:..||                  |
Human    12 ERFSFEDSDRFEEDSLCSFISEAESLCQNWRGWRKQSAGPNSPTGG------------------G 58

  Fly    67 GAGASGSCTPGGNGTAMANTSTCGRHYEVSTLAELAARCVASYIPFELVEHVYPPVPEQLQLRIA 131
            |.|.||       ||.|       |...|..|.||:|:.||.:||||:||.||||||||||||||
Human    59 GGGGSG-------GTRM-------RDGLVIPLVELSAKQVAFHIPFEVVEKVYPPVPEQLQLRIA 109

  Fly   132 FWSFPDNEEDIRLYSCLANSSADEFNRGDSLFRLRAVKDPLQIGFHLSASVVNQ---TPRAYFNV 193
            |||||:|||||||||||||.|||||.|||.|||:|||||||||||||||:||..   .|:..:||
Human   110 FWSFPENEEDIRLYSCLANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVVPPQMVPPKGAYNV 174

  Fly   194 AVTFDRRRISSCNCTCTSSAYWCSHVVAVCLHRIHCPQEVCLRAPVSESLTRLQRDQLQKFAQYL 258
            ||.|||.|::||:|||.:.|.||:||||:||.|||....|||||||||||:||||||||||||||
Human   175 AVMFDRCRVTSCSCTCGAGAKWCTHVVALCLFRIHNASAVCLRAPVSESLSRLQRDQLQKFAQYL 239

  Fly   259 ISELPQQILPTAQRLLDELLSAQPTAINTVCGAPDPTAGASINDQTSWYLDEKTLHNNIKRILIK 323
            |||||||||||||||||||||:|.|||||||||||||||.|.:||::|||||.||.:|||:.|.|
Human   240 ISELPQQILPTAQRLLDELLSSQSTAINTVCGAPDPTAGPSASDQSTWYLDESTLTDNIKKTLHK 304

  Fly   324 FCLPAPIVFSDVN--YLTNSAPPAAAEWSSLLRPLRGREPEGMWNLLSIVREMYRRCDRNAVRLL 386
            ||.|:|:||||||  ||:::.|||||||:.||||||||||||:||||||||||::|.|.||..||
Human   305 FCGPSPVVFSDVNSMYLSSTEPPAAAEWACLLRPLRGREPEGVWNLLSIVREMFKRRDSNAAPLL 369

  Fly   387 EIITEECLYCDQILIWWFQTKLALMMGSHGHSGGKHSNTHSNSTALQHACSSLCDEIVALWRLAA 451
            ||:|::||..:||..||:..:.:   .||..:.|....::..|....|||:|:|||:|.|||||.
Human   370 EILTDQCLTYEQITGWWYSVRTS---ASHSSASGHTGRSNGQSEVAAHACASMCDEMVTLWRLAV 431

  Fly   452 LNPGLAPDERDMLHAQFTAWHLKILDRVVKSRMMPSYTNKHQQNSRSETELFIGFKPAIEACYLD 516
            |:|.|:|..|..|..|...|.||:::.|           |..|:.::...||.||:||:||||.:
Human   432 LDPALSPQRRRELCTQLRQWQLKVIENV-----------KRGQHKKTLERLFPGFRPAVEACYFN 485

  Fly   517 W-EGYPIPGVTHTHDTNPIYYSPFTCFKHTDLKGESNNPGQLNATQALMSNNKHYNYFSSSSDHG 580
            | |.||:||||::.....:    ..|:    .:...:.||                        .
Human   486 WEEAYPLPGVTYSGTDRKL----ALCW----ARALPSRPG------------------------A 518

  Fly   581 MHAGAFKQRLDRPFRESRFYTNPA--DLDGGAALAGGGSG---------------------RFST 622
            ..:|..::..|||   ....|.||  ..:.|....|.|.|                     :...
Human   519 SRSGGLEESRDRP---RPLPTEPAVRPKEPGTKRKGLGEGVPSSQRGPRRLSAEGGDKALHKMGP 580

  Fly   623 GLGSV-AVGGAGAGGLGQMSGGVNNSVGG-SAAAEVNPVQQQLPSGSAGVGASVTNAKVVVATDG 685
            |.|.. |:||||:|..|...||....:.. .::.|.:..:..|...|..:||
Human   581 GGGKAKALGGAGSGSKGSAGGGSKRRLSSEDSSLEPDLAEMSLDDSSLALGA------------- 632

  Fly   686 NRSSASSEGFCENDDFGGDTSSSHNYCPPGQAVVPGQKSALT----ESDSQSSFDAVSHQSKDEP 746
                       |...|||...|     ||...:..|.:...|    ..|:......|......||
Human   633 -----------EASTFGGFPES-----PPPCPLHGGSRGPSTFLPEPPDTYEEDGGVYFSEGPEP 681

  Fly   747 PVGGVGVAVGVEQALSTSDTSSASSSSSSASTASGSSNSSTSSMLMAGQEATVGVGGAVQQTTRR 811
            |...||     ...|...|..:.....|:..:.:|         |...:||...||
Human   682 PTASVG-----PPGLLPGDVCTQDDLPSTDESGNG---------LPKTKEAAPAVG--------- 723

  Fly   812 LSKDESFSSSSDEFN------QGGVGGSAGRVAMASSGSGSGAGDTVAVGSGSTAGGDLTPVPST 870
                    ...|::.      |.|.||...:
Human   724 --------EEDDDYQAYYLNAQDGAGGEEEK---------------------------------- 746

  Fly   871 SAAARAALAASSTGPVISASPHLAASAAGGLGVLGVGADQPCTSSAHAARALAAAVAASSDKPHV 935
                                      |.||.|                            ::..:
Human   747 --------------------------AEGGAG----------------------------EEHDL 757

  Fly   936 FSNVRP--TEDAWDILLARAEGLHAHGHGAEACILAVRLAEQMLANPPNLLLELPPAPKRKGKKQ 998
            |:.::|  .|...::|.|.||.|||||:.:||..|.|.||:.:|||||:|.:|.|||   ||||.
Human   758 FAGLKPLEQESRMEVLFACAEALHAHGYSSEASRLTVELAQDLLANPPDLKVEPPPA---KGKKN 819

  Fly   999 NVNPISHQLTVVASATLSKCAFLCTVLSENSEHYHIGFRICLFALEMPRPPASTKPLEVKLANQE 1063
            .|:  :.:.|.||:.||||.|||.|||||..||:::.||:.:||||:.|||||||.||||||.||
Human   820 KVS--TSRQTWVATNTLSKAAFLLTVLSERPEHHNLAFRVGMFALELQRPPASTKALEVKLAYQE 882

  Fly  1064 ADILALLKRLPLGSAELQVIRERAEQLRSGTFKTRGEALLPINLATFIFDALV--TLSPLGGSTI 1126
            :::.||||::|||.:|:..:|.|||:||.||. .....:||:.||:||||.|.  .:||
Human   883 SEVAALLKKIPLGPSEMSTMRCRAEELREGTL-CDYRPVLPLMLASFIFDVLCAPVVSP------ 940

  Fly  1127 VPGVASTSGVSSAAGKSMVNTGTRLLLYKHNS----DESLGFDAAVAALGLKANVSEAEHPLLCE 1187
                                ||:|......||    ||.|||:|||||||:|..|||||||||||
Human   941 --------------------TGSRPPSRNWNSETPGDEELGFEAAVAALGMKTTVSEAEHPLLCE 985

  Fly  1188 GTRRQRGDLALTLLSHYKDEPRKIAKIMEKLLDRDIHTLLNAP-LLPAYYSSNPPVRTRSNQPTR 1251
            ||||::|||||.|:..|||:..|:.||::|||||:..|  :.| .|.::|||:.|.......|::
Human   986 GTRREKGDLALALMITYKDDQAKLKKILDKLLDRESQT--HKPQTLSSFYSSSRPTTASQRSPSK 1048

  Fly  1252 REDHDYGGGSGCASSNCNPVANLCELLPADYGSVGG---------------NSRPHSSTSAELEL 1301
                 :||.|  |.....|:.: ....||..|||.|               .|.|||...
Human  1049 -----HGGPS--APGALQPLTS-GSAGPAQPGSVAGAGPGPTEGFTEKNVPESSPHSPCE----- 1100

  Fly  1302 SMCALSMASSGSQSGGVQGMVPTTNAAGTTG-----------------------------TPSSS 1337
                 .:.|..:.:...:|.||:..|.|:.|                             |.|.|
Human  1101 -----GLPSEAALTPRPEGKVPSRLALGSRGGYNGRGWGSPGRPKKKHTGMASIDSSAPETTSDS 1160

  Fly  1338 STTVSGSQNPNGNPSGSGGGGNG------------GGGNGGGGGGGGGGGGSTSSRSKESRYKGK 1390
            |.|:|......|....|.|.|..            |..:..|.......||:.:...:..||||:
Human  1161 SPTLSRRPLRGGWAPTSWGRGQDSDSISSSSSDSLGSSSSSGSRRASASGGARAKTVEVGRYKGR 1225

  Fly  1391 RA---YPSIPNQPSEASAHFMFELAKNVLTKAGGNSSTSLFTQASTSQNHHGPHRALHMCAFQLG 1452
            |.   .|.:|||||||:|||.|||||.||.|||||||||:||..|:|..|.||||.||:|||::|
Human  1226 RPESHAPHVPNQPSEAAAHFYFELAKTVLIKAGGNSSTSIFTHPSSSGGHQGPHRNLHLCAFEIG 1290

  Fly  1453 LYALGLHNCVSPNWLSRTYSSHVSWILGQAMEIGAPAISFLIDTWEAHLTPPEAAGMADRASRGW 1517
            ||||||||.|||||||||||||||||.|||||||:.|::.|::.|:.||||||.|.:||||||..
Human  1291 LYALGLHNFVSPNWLSRTYSSHVSWITGQAMEIGSAALTILVECWDGHLTPPEVASLADRASRAR 1355

  Fly  1518 DSNMVYPAAELALSVLPHAAALNPNEIQRAILQCKEQSDLMLERACLTVETAAKGGGVYPEVLFQ 1582
            |||||..|||||||.||||.||||||||||::|||||.:||||:||:.||.|||||||||||||:
Human  1356 DSNMVRAAAELALSCLPHAHALNPNEIQRALVQCKEQDNLMLEKACMAVEEAAKGGGVYPEVLFE 1420

  Fly  1583 VARYWYELYMRNTPNNSEFEPHDDTMDHSAVSLSALIESQQQHELQQQQQAVQQQQAVQQQQQVV 1647
            ||..|:.||.:....:|       |....|.|.||                    ..::...:..
Human  1421 VAHQWFWLYEQTAGGSS-------TAREGATSCSA--------------------SGIRAGGEAG 1458

  Fly  1648 QQQQQVVQQQQQLGMPNSVVPGGVGPGPGLPVAVQPPVVGSVQNPQAQFQPVGVASLAPLGLAQ- 1711
            :            |||.    |..|||.                     :||.||:.|....|.
Human  1459 R------------GMPE----GRGGPGT---------------------EPVTVAAAAVTAAATV 1486

  Fly  1712 YPPYSFCQGLYAHHHNMSYPPGQMQMFISAGPPPPPQAYGGYQQPPPQQPPNPQQQQQVVQQQVQ 1776
            .|..|....||.       .||     :..|..|....|...|   |..|.:||
Human  1487 VPVISVGSSLYP-------GPG-----LGHGHSPGLHPYTALQ---PHLPCSPQ----------- 1525

  Fly  1777 QQQVVQQQQQQVQMAGQAPPGHPGQQGHPGQP-----PSGFQPQPPPGAF------QALPPQAYQ 1830
                        .:...|.|.||  ..|..:|     ||...||....||      .::.|.:..
Human  1526 ------------YLTHPAHPAHP--MPHMPRPAVFPVPSSAYPQGVHPAFLGAQYPYSVTPPSLA 1576

  Fly  1831 AMQAGPPGPPMGP--PQGYYGPPPPPPPNGPPGVGVGVGVGVGVGVMPMRQHQHQHPVYPFMQQA 1893
            |.....|.|.|.|  ...|:..|..|.|........|.|....|         |....:|.:|.|
Human  1577 ATAVSFPVPSMAPITVHPYHTEPGLPLPTSVACELWGQGTVSSV---------HPASTFPAIQGA 1632

  Fly  1894 PPQPPQQQQPPP-----SQPPVRQRQPHQFTPTQLRYLLAAYNVGMLAMETLARRVHDDRPQAKY 1953
             ..|....||.|     ..||..:.......|..|.:|.|||.|||||:|.|.||.|:|.|. .:
Human  1633 -SLPALTTQPSPLVSGGFPPPEEETHSQPVNPHSLHHLHAAYRVGMLALEMLGRRAHNDHPN-NF 1695

  Fly  1954 ARNPPYGEDVKWLLRISKKLGTQY 1977
            :|:|||.:||||||.::.|||.::
Human  1696 SRSPPYTDDVKWLLGLAAKLGDRH 1719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34401	NP_001356949.1	None
ZSWIM8	XP_005269705.1	SWIM	131..>263	CDD:302896	99/131 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159870
Domainoid	1	1.000	1090	1.000	Domainoid score	I21
eggNOG	1	0.900	-	-		E1_KOG3615
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1366	1.000	Inparanoid score	I129
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D54901at33208
OrthoFinder	1	1.000	-	-		FOG0006333
OrthoInspector	1	1.000	-	-		oto89531
orthoMCL	1	0.900	-	-		OOG6_107078
Panther	1	1.100	-	-	LDO	PTHR22619
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3876
SonicParanoid	1	1.000	-	-		X4608
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.880