DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34401 and Zswim4

DIOPT Version :9

Sequence 1:	NP_001356949.1	Gene:	CG34401 / 50356	FlyBaseID:	FBgn0085430	Length:	2371	Species:	Drosophila melanogaster
Sequence 2:	NP_766091.2	Gene:	Zswim4 / 212168	MGIID:	2443726	Length:	1101	Species:	Mus musculus

Alignment Length:	2075	Identity:	374/2075 - (18%)
Similarity:	561/2075 - (27%)	Gaps:	1032/2075 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PPFGGAGASGSCTPGGNGTAMANTSTCGRHYEVSTLAELAARCVASYIPFELVEHVYPPVPEQLQ 127
            ||  .|..|..| |.|:     ...|..|......|.:|:|:.||....||.||..:..|||.:|
Mouse     3 PP--AAKRSRGC-PAGD-----EPGTGARRSRPEPLLDLSAKRVAESWAFEQVEERFSRVPEPVQ 59

  Fly   128 LRIAFWSFPDNEEDIRLYSCLANSSAD-------EFNRGDSLFRLRAVKDPLQIGFHLSASVVN- 184
            .||.|||||.:|.:|.:||.|.....:       .|.||..|.:..||...||:|||||.::..
Mouse    60 KRIVFWSFPRSEREICMYSSLGYQPPEGEQDTRVPFTRGLHLLQSGAVDRVLQVGFHLSGNIREV 124

  Fly   185 ---QTPRAYFNVAVTFDRRRISSCNCTCTS-SAYWCSHVVAVCLHRIHCPQEVCLRAPVSESLTR 245
               ..|...::|:::|||.:|:|.:|.|.: ..::|:||||:.|:||...::|.||.|:||:|::
Mouse   125 GGPGEPEHLYHVSISFDRCKITSVSCGCDNRDLFYCAHVVALSLYRIRHARQVELRLPISETLSQ 189

  Fly   246 LQRDQLQKFAQYLISELPQQILPTAQRLLDELLSAQPTAINTVCGAPDPTAGASINDQTSWYLDE 310
            :.|||||||.|||||....::|||||||.||:| ...:.||.|.|||||||||...|...|:|||
Mouse   190 MNRDQLQKFVQYLISAHHTEVLPTAQRLADEIL-LLGSEINLVHGAPDPTAGAGTEDANCWHLDE 253

  Fly   311 KTLHNNIKRILIKFCLPAPIVFSDVNYLTNSAPPAAAEWSSLLRPLRGREPEGMWNLLSIVREMY 375
            :.:...:|::                 |:|.....|::      .||        ::.|.||||.
Mouse   254 EQIQEQVKQL-----------------LSNGGHYGASQ------QLR--------SMFSKVREML 287

  Fly   376 RRCDRNAVRLLEIITEECLYCDQILIWWFQTKLALMMGSHGHSGGKHSNTHSNSTALQHACSSLC 440
            |..|.|..|:|.::||:.|...::.:|                       ......:...|..|.
Mouse   288 RARDSNGARMLILMTEQFLQDPRLALW-----------------------RQQGAGMTDKCRQLW 329

  Fly   441 DEIVALWRLAALNPGLAPDERDMLHAQFTAWHLKILDRVVKSRMMPSYTNKHQQNSRSETELFIG 505
            ||:.|||....|:|...||||       :.| |::|                            |
Mouse   330 DELGALWVCVILSPHCKPDER-------SGW-LQLL----------------------------G 358

  Fly   506 FKPAIEACYLDWEGY--PIPGV-------THTHDTNPIYYSPFTCFKHTDLKGESNNPGQLNATQ 561
            ....::.|.|:...|  .||.:       |.:.|...:               .:.:|.:...::
Mouse   359 TWDKLDVCPLEEGNYSLDIPSLQPALTSRTGSEDEEEV---------------TAASPRRTVFSR 408

  Fly   562 ALMSNNKHYNYFSSSSDHGMHAGAFKQRLDRPFRESRFYTNPADLDGGAALAGGGSGRFSTGLGS 626
            ||.:...|:|            .:..||:                     ||....|...||
Mouse   409 ALQAGELHWN------------DSHLQRI---------------------LASDSCGPTLTG--- 437

  Fly   627 VAVGGAGAGGLGQMSGGVNNSVGGSAAA---EVNPV--QQQLPSGSAGVGASVTNAKVVVATDGN 686
                                |:|.....   :.:|:  .:..|:..|.|
Mouse   438 --------------------SMGSDKPTFDPQGHPIWLGEPFPTACARV---------------- 466

  Fly   687 RSSASSEGFCENDDFGGDTSSSHNYCPPGQAVVPGQKSALTESDSQSSFDAVSHQSKDEPPVGGV 751
                             ||..:|.|  |.:|
Mouse   467 -----------------DTLRAHGY--PHKA---------------------------------- 478

  Fly   752 GVAVGVEQALSTSDTSSASSSSSSASTASGSSNSSTSSMLMAGQEATVGVGGAVQQTTR--RLSK 814
                                                           :.:..|:..|.|  |..:
Mouse   479 -----------------------------------------------LRLACAIINTLRLQRRHQ 496

  Fly   815 DESFSSSSDEFNQGGVGGSAGRVAMASSGSGSGAGDTVAVGSGSTAGGDLTPVPSTSAAARAALA 879
            .||:.....|..|.|                       |.|..||.|....|:.......||.|
Mouse   497 LESYKQQKKELLQKG-----------------------ATGVTSTEGWVGHPLDPIGCLCRALL- 537

  Fly   880 ASSTGPVISASPHLAASAAGGLGVLGVGADQPCTSSAHAARALAAAVAASSDKPHVFSNVRPTED 944

Mouse   538 ----------------------------------------------------------------- 537

  Fly   945 AWDILLARAEGLHAHGHGAEACILAVRLAEQMLANPPNLLLELPPAPKRKGKKQNVNPISHQLTV 1009
                               |||    ||.|:    |.:|..:..| .|||        :::|..:
Mouse   538 -------------------EAC----RLEEE----PHSLFPDSAP-EKRK--------LAYQHVL 566

  Fly  1010 VASATLSKCAFLCTVLSENSEHYHIGFRICLFALEMPRPPASTKPLEVKLANQEADILALLKRLP 1074
            |..             |....:..:...:.|..|...|........:.|:...|..:||||:.:.
Mouse   567 VPG-------------SPGESYLALALEVALLGLGQQRALPEGLYAQDKVVRNEEQLLALLEEVE 618

  Fly  1075 LGSAELQVIRERAE-QLRSGTFKTRGEAL----LPIN-LATFIFDALVTLSPLGGSTIVPGVAST 1133
            |....:||:|::|. .|..|.|...||.:    :|:: .|.::|.||:...|
Mouse   619 LDERLVQVLRKQAGLLLEGGPFSGFGEVIFRESVPMHTCARYLFTALLPHDP------------- 670

  Fly  1134 SGVSSAAGKSMVNTGTRLLLYKHNSDESLGFDAAVAALGLKANVSEAEHPLLCEGTRRQRGDLAL 1198
                                                                         |||.
Mouse   671 -------------------------------------------------------------DLAF 674

  Fly  1199 TLLSHYKDEPRKIAKIMEKLLDRDIHTLLNAPLLPAYYSSNPPVRTRSNQPTRREDHDYGGGSGC 1263
            .|                         .|.|..||...::.|                      .
Mouse   675 RL-------------------------ALRAMRLPVLETTFP----------------------A 692

  Fly  1264 ASSNCNPVANLCELLPADYGSVGGNSRPHSSTSAELELSMCALSMASSGSQSGGVQGMVPTTNAA 1328
            ..|:.||:           .|:..|..|.......||...|.|                     |
Mouse   693 GESHPNPL-----------DSIMSNRFPRWFILGHLETRQCEL---------------------A 725

  Fly  1329 GTTGTPSSSST----TVSGSQNPNGNPSGSGGGGNGGGGNGGGGGGGGGGGGSTSSRSKESRYKG 1389
            .|..|.:...|    .|.||...|.:
Mouse   726 STMLTAAKGDTKWLHAVLGSVQQNIH--------------------------------------- 751

  Fly  1390 KRAYPSIPNQPSEASAHFMFELAKNVLTKAGGNSSTSLFTQASTSQNHHGPHRALHMCAFQLGLY 1454
                          |...:|:||::....|         |.||..     |...|...|.:|||.
Mouse   752 --------------SPALLFKLAQDACKTA---------TPASAP-----PDTVLLGIALELGLQ 788

  Fly  1455 ALGLHNCVSPNWLSRTYSSHVSWILGQAMEIGAPAISFLIDTWEAHLTPPEAAGMADRASRGWDS 1519
            .:.: ...:..|..|   ..|.|::..|.|||.||:..::..|.:..||.||..:
Mouse   789 VMRM-TLNTMTWRRR---EMVRWLVSCATEIGPPALMSIMKNWYSLFTPVEAVTI---------- 839

  Fly  1520 NMVYPAAELALSVLPHAAALNPNEIQRAILQCKEQSDLMLERACLTVETAAKGGGVYPEVLFQVA 1584
                    :|::...||..|.                       |.::||.:      |.|:..|
Mouse   840 --------VAVTGTTHATLLR-----------------------LQLDTAGR------EELWACA 867

  Fly  1585 RYWYELYMRNTPNNSEFEPHDDTMDHSAVSLSALIESQQQHELQQQQQAVQQQQAVQQQQQVVQQ 1649
            |                     |:
Mouse   868 R---------------------TL----------------------------------------- 870

  Fly  1650 QQQVVQQQQQLGMPNSVVPGGVGPGPGLPVAVQPPVVGSVQNPQAQFQPVGVASLAPLGLAQYPP 1714
                                      .|..|::.|     ||                  ...|.
Mouse   871 --------------------------ALQCAMKDP-----QN------------------CALPA 886

  Fly  1715 YSFCQGLYAHHHNMSYPPGQMQMFISAGPPPPPQAYGGYQQPPPQQPPNPQQQQQVVQQQVQQQQ 1779
            .:.|:..:|
Mouse   887 LTLCEKNHA-------------------------------------------------------- 895

  Fly  1780 VVQQQQQQVQMAGQAPPGHPGQQGHPGQPPSGFQPQPPPGAFQALPPQAYQAMQAGPPGPPMGPP 1844
                                                    ||:|    |||.:.....|
Mouse   896 ----------------------------------------AFEA----AYQIVLDAAAG------ 910

  Fly  1845 QGYYGPPPPPPPNGPPGVGVGVGVGVGVGVMPMRQHQHQHPVYPFMQQAPPQPPQQQQPPPSQPP 1909
                                      |:|      |.|...|..:|:
Mouse   911 --------------------------GLG------HAHLFTVARYME------------------ 925

  Fly  1910 VRQRQPHQFTPTQLRYLLAAYNVGMLAMETLARRVHDDRPQAKYARNPPYGEDVKWLLRISKKLG 1974
                  |:..|      |.||.:..||:..|:...:.|        :.|...||.|...:|..||
Mouse   926 ------HRGLP------LRAYKLATLALAQLSIAFNQD--------SHPAVNDVLWACSLSHSLG 970

  Fly  1975 TQYLHQFCICAVNSIVSPFVLHDVAIE---SAHYLGRNNHQMVMQHLRSALTPLVQKCQQM---- 2032
            ...|.......:.||....:|.|:...   ||..||....:...:.|.:...||   ||.:
Mouse   971 RHELSAIVPLIIRSIHCAPMLSDILRRWTLSAPGLGPLGARRATKPLGTDRAPL---CQLLDAAV 1032

  Fly  2033 --YIQCIHQKLYHLTQGDYEEFASIVVAARAAFQITPEGNAQFKDWLQSIKRSKSCKKEL 2090
              ||...|.:|.|::...|.:|...:..||..|.:.|:|:.||..:|:::|::...||:|
Mouse  1033 AAYITTSHSRLTHISPRHYGDFIEFLGKARETFLLAPDGHLQFAQFLENLKQTYKGKKKL 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34401	NP_001356949.1	None
Zswim4	NP_766091.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3615
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900