DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34401 and zswim8

DIOPT Version :9

Sequence 1:	NP_001356949.1	Gene:	CG34401 / 50356	FlyBaseID:	FBgn0085430	Length:	2371	Species:	Drosophila melanogaster
Sequence 2:	XP_005156782.1	Gene:	zswim8 / 100148379	ZFINID:	ZDB-GENE-050320-59	Length:	1933	Species:	Danio rerio

Alignment Length:	2250	Identity:	883/2250 - (39%)
Similarity:	1150/2250 - (51%)	Gaps:	478/2250 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DRFSFDDSIRFEEDSLCSWSSEPESLCNNWRGWKKPAAGSGAGNGGLSGMGGMAVAGGSGAPPFG 66
            :||||:||.|||||||||:.||.||||.|||||:|.:||..:..        :.:..|
Zfish    12 ERFSFEDSDRFEEDSLCSFISEAESLCQNWRGWRKQSAGPNSPT--------VKIKDG------- 61

  Fly    67 GAGASGSCTPGGNGTAMANTSTCGRHYEVSTLAELAARCVASYIPFELVEHVYPPVPEQLQLRIA 131
                                       :|..|.||:|:.||.:||||:||.||||||||||||||
Zfish    62 ---------------------------QVIPLVELSAKQVAFHIPFEVVEKVYPPVPEQLQLRIA 99

  Fly   132 FWSFPDNEEDIRLYSCLANSSADEFNRGDSLFRLRAVKDPLQIGFHLSASVVN----QTPRAYFN 192
            :||||:|||||||||||||.|.|||.||:.|:|:|||||||||||||||:||:    |:..|| |
Zfish   100 YWSFPENEEDIRLYSCLANGSPDEFQRGEQLYRVRAVKDPLQIGFHLSATVVSPQAGQSKGAY-N 163

  Fly   193 VAVTFDRRRISSCNCTCTSSAYWCSHVVAVCLHRIHCPQEVCLRAPVSESLTRLQRDQLQKFAQY 257
            |||.|||.||:||:|||.:.|.||:||||:||.|||....|||||||||||:|||||||||||||
Zfish   164 VAVMFDRCRITSCSCTCGAGAKWCAHVVALCLFRIHNASAVCLRAPVSESLSRLQRDQLQKFAQY 228

  Fly   258 LISELPQQILPTAQRLLDELLSAQPTAINTVCGAPDPTAGASINDQTSWYLDEKTLHNNIKRILI 322
            ||||||||||||||||||||||:|.|||||||||||||||.|.:||::|||||.||.:|||:.|.
Zfish   229 LISELPQQILPTAQRLLDELLSSQSTAINTVCGAPDPTAGPSASDQSTWYLDESTLSDNIKKTLH 293

  Fly   323 KFCLPAPIVFSDVN--YLTNSAPPAAAEWSSLLRPLRGREPEGMWNLLSIVREMYRRCDRNAVRL 385
            |||.|:|:||||||  ||:::.|||||||:.||||||||||||:||||||||||::|.|.||..|
Zfish   294 KFCGPSPVVFSDVNSMYLSSTEPPAAAEWACLLRPLRGREPEGIWNLLSIVREMFKRRDSNAAPL 358

  Fly   386 LEIITEECLYCDQILIWWFQTKLALMMGSHGHSGGKHSNTHSNSTALQHACSSLCDEIVALWRLA 450
            |||:||:||..:||:.||:..:.:   .||..:.|....::..:....|||:|:|||:|.|||||
Zfish   359 LEILTEQCLTHEQIIGWWYSVRTS---ASHSSASGHTGRSNGQTEVAAHACASMCDEMVVLWRLA 420

  Fly   451 ALNPGLAPDERDMLHAQFTAWHLKILDRVVKSRMMPSYTNKHQQNSRSETELFIGFKPAIEACYL 515
            .|:|.::|..|..|.||...||||:::.|           |..|:.:|..:||.|||||:|.||.
Zfish   421 VLDPTMSPQRRLELAAQLKQWHLKVIEIV-----------KRGQHRKSLDKLFQGFKPAVECCYF 474

  Fly   516 DWE-GYPIPGVTHTH-DTNPIYYSPFTCFKHTDLKGESNNPGQLNATQALMSNNKHYNYFSSSSD 578
            :|| .||:||:|:.: |...:.:    |:...           :...:.|.:.|      ||.:.
Zfish   475 NWEVAYPLPGITYCNADKKNVSF----CWARA-----------MQQQRGLKAIN------SSEAG 518

  Fly   579 HGMHAGA-------FKQRLDRPFRESRFYTNPAD--LDGGAALAGGGSGRFSTGLGSVAVGGAGA 634
            .|..:|.       .|.|.:....:......|.:  :.....::...||.....||| .|..:..
Zfish   519 EGARSGTSEGNSLEHKSRSNSHLPQQEVAVRPKETIVSKRKVVSNVNSGSVLVCLGS-RVPLSLP 582

  Fly   635 GGLGQMSGGVNNSVGGSAAAEVNPVQQQLPSGSAGVGASVTNAKVVVATDGNRSSASSEGFCEND 699
            .|...|....|:|......|::....:.....|:||.....:||        |.::|.:...|.|
Zfish   583 DGSKSMYKTTNSSPSAGTKAKLTQSSKGSCGSSSGVSGKHPSAK--------RRTSSEDSSLEPD 639

  Fly   700 ------------DFGGDTSSSHNYCPPGQAVVPGQKSALTESDSQSSFDAVSHQSKDEPPVGGVG 752
                        ..|.:..::.::.||...::|...:.|.:....||      .||
Zfish   640 MAELNLDDGSSMALGAEACNTFDFLPPPPEMLPSPSTLLQKPLKYSS------NSK--------- 689

  Fly   753 VAVGVEQALSTSDTSSASSSSSSASTASGSSNSSTSSMLMAGQEATVGVGGAVQQTTRRLSKDES 817
                 |:|..|.....|:.:.     |..|..||.::.::|..|..|.|         ....||:
Zfish   690 -----ERAFETKRVPHAADAH-----ACFSKESSIAAPVVAAMEKEVEV---------EADLDEN 735

  Fly   818 FSSSSDEFNQGGVGGSAGRVAMASSGSGSGAGDTVAVGSGSTAGGDLTPVPSTSAAARAALAASS 882
             ....|..:..|...|....|....|.|.|||                             |:.:
Zfish   736 -GGDEDVIDDAGPSDSLPSKAQRGHGEGDGAG-----------------------------ASGA 770

  Fly   883 TGPVISASPHLAASAAGGLGVLGVGADQPCTSSAHAARALAAAVAASS--DKPHVFSNVRPTED- 944
            .||.:       |.||.|...:|....|....||.:.......||.|:  ::|.:|:.::|.|.
Zfish   771 PGPQV-------AEAAAGADAVGEDDYQAYYLSAASEEGAERGVADSNHEEEPDIFAGIKPLEQE 828

  Fly   945 -AWDILLARAEGLHAHGHGAEACILAVRLAEQMLANPPNLLLELPPAPKRKGKKQNVNPISHQLT 1008
             ..::|.|.||.|:|||:..|||.|||.||..:|||||:|.:|   .|:.||||..|:  :.:.|
Zfish   829 GRMEVLFACAEALYAHGYSNEACRLAVDLARDLLANPPDLKVE---QPQTKGKKSKVS--TTKQT 888

  Fly  1009 VVASATLSKCAFLCTVLSENSEHYHIGFRICLFALEMPRPPASTKPLEVKLANQEADILALLKRL 1073
            .||:.||||.|||.|||||..|.:::.|...:|:||:.|||||||.||||||.||::::||||::
Zfish   889 QVATNTLSKVAFLLTVLSERLELHNLAFNTGMFSLELQRPPASTKALEVKLAYQESEVVALLKKI 953

  Fly  1074 PLGSAELQVIRERAEQLRSGTFKTRGEALLPINLATFIFDALVT--LSPLGG-------STIVPG 1129
            |||..|:..||:||||||.|.| .....:||:.||:||||.|.|  :||.|.       :..:||
Zfish   954 PLGIVEMTSIRDRAEQLRDGNF-CDYRPVLPLMLASFIFDVLCTPVVSPTGSRPPSRNRNNEMPG 1017

  Fly  1130 VASTSGVSSAAGKSMVNTGTRLLLYKHNSDESLGFDAAVAALGLKANVSEAEHPLLCEGTRRQRG 1194
                                         ||.|||:|||||||:|..|||||||||||||||::|
Zfish  1018 -----------------------------DEELGFEAAVAALGMKTTVSEAEHPLLCEGTRREKG 1053

  Fly  1195 DLALTLLSHYKDEPRKIAKIMEKLLDRDIHTLLNAP-LLPAYYSSNPPVRTRSNQPTRREDHDYG 1258
            ||||.|:..|||:..|:.||::|||||:..|  :.| .|.::|||.|...::.: |::...|...
Zfish  1054 DLALALMITYKDDQSKLKKILDKLLDRESQT--HKPQTLSSFYSSKPATSSQKS-PSKHATHGAS 1115

  Fly  1259 GGSGCASSNCNPVANLCELLPADYGSVGGN-----SRPHSSTSAELELSMCALSMASSGSQSGGV 1318
            |.:|..|.: .|.|....:.....|...|.     ....|:.|.|        |::.:..|:.|.
Zfish  1116 GATGGVSKH-TPTATSTAVQGMTSGGAAGQQGGLAGGVQSTASGE--------SISDNRDQAEGA 1171

  Fly  1319 Q----------------GMVPTTNAAGTTG-----------------------------TPSSSS 1338
            |                |.||:..|.|..|                             |.|.||
Zfish  1172 QSTSCDQQSEAAPFKPEGTVPSRLALGGRGAYGTRCWGSPVRQKKKHTGMASIDSSAPETTSDSS 1236

  Fly  1339 TTVSGSQNPNGNPSGSGGGGNGGG----------GNGGGGGGGGGGGGSTSSRSKESRYKGKRA- 1392
            .|:|......|..:.|.|.|....          |:....|....|||:.:..:..|||||:|.
Zfish  1237 PTLSRRPIRGGWTATSWGRGQDSDSISSSSSDSLGSSSSSGSRRAGGGARAKSTDTSRYKGRRPE 1301

  Fly  1393 --YPSIPNQPSEASAHFMFELAKNVLTKAGGNSSTSLFTQASTSQNHHGPHRALHMCAFQLGLYA 1455
              .|.:|||||||:|||.|||||.||.|||||||||:|||.|.|..|.||||.||:|||::||||
Zfish  1302 CHAPHVPNQPSEAAAHFYFELAKTVLIKAGGNSSTSIFTQPSASGGHQGPHRNLHLCAFEIGLYA 1366

  Fly  1456 LGLHNCVSPNWLSRTYSSHVSWILGQAMEIGAPAISFLIDTWEAHLTPPEAAGMADRASRGWDSN 1520
            |||||.|||||||||||||||||.|||||||:.|::.|::.|:.||||||.|.:||||||..|.|
Zfish  1367 LGLHNFVSPNWLSRTYSSHVSWITGQAMEIGSAALNILVECWDGHLTPPEVASLADRASRARDPN 1431

  Fly  1521 MVYPAAELALSVLPHAAALNPNEIQRAILQCKEQSDLMLERACLTVETAAKGGGVYPEVLFQVAR 1585
            ||..|||||||.||||.||||||||||::|||||.::|||:||:.||.|||||||||||||:||.
Zfish  1432 MVRAAAELALSCLPHAHALNPNEIQRALVQCKEQDNVMLEKACMAVEEAAKGGGVYPEVLFEVAH 1496

  Fly  1586 YWYELYMR-----------------------NTPNNSEFEPHDDT--MDHSAVSLSALIESQQQH 1625
            .||.||.:                       .||........|:|  :|.|.||
Zfish  1497 QWYWLYEQTVGGGSGSQREGSGRCGANGGAGRTPPEGGCGILDNTGALDSSGVS----------- 1550

  Fly  1626 ELQQQQQAVQQQQAVQQQQQVVQQQQQVVQQQQQLGMPNSVVPGGVGPGPGLPVAVQPPVVGSVQ 1690
                   ||...........|:.....:.|..   .:|.|.:....|..|...:....|.|.:.|
Zfish  1551 -------AVTTTVTAAAVVPVISVGSTIYQSH---ALPGSAMAHTQGLHPYTTIQTHLPTVCTPQ 1605

  Fly  1691 NPQAQFQPVGVASLAPLGLAQYPPYSFCQGLYAHHHNMSYPPG-QMQMFISAGPPPPPQAYGGYQ 1754
            ......|.|...::.|:..|.||        ..:....:|.|| :...|.|.|..|   |:.|.|
Zfish  1606 YLGHPLQHVPRPAVFPVSGAAYP--------QVYELRKAYQPGLKSACFSSQGMHP---AFIGAQ 1659

  Fly  1755 QPPPQQPPNPQQQQQVVQQQVQQQQVVQQQQQQVQMA-GQAPPGHPGQQGHPGQP-PSGFQ--PQ 1815
            .|                               ..:| |..||........||.| ||..|  ..
Zfish  1660 YP-------------------------------FSVATGPHPPLAATAVTFPGVPVPSMTQIAVH 1693

  Fly  1816 PPPGAFQALP-----------PQAYQAMQ-AGPPGPPMGPPQGYYGPPPPPPPNGPPGVGVGVGV 1868
            |...|..|||           ..|.||:| |..||....||.....|
Zfish  1694 PYHTAEAALPLTTTVAGGVHAGAAIQAIQGASLPGLSSQPPSLVSAP------------------ 1740

  Fly  1869 GVGVGVMPMRQHQHQHPVYPFMQQAPPQPPQQQQPPPSQPPVRQRQPHQFTPTQLRYLLAAYNVG 1933
                  .|:...||..|:   .||.                             |.||.:||.||
Zfish  1741 ------FPVEDEQHSQPI---SQQG-----------------------------LHYLHSAYRVG 1767

  Fly  1934 MLAMETLARRVHDDRPQAKYARNPPYGEDVKWLLRISKKLGTQYLHQFCICAVNSIVSPFVLHDV 1998
            |||:|.|.||.|:|.|. .::|:|||.|||||||.::.:||..:::|||:.|...::|||||.::
Zfish  1768 MLALEMLGRRAHNDHPN-NFSRSPPYTEDVKWLLGLAARLGVNHVYQFCVGAAKGVLSPFVLQEI 1831

  Fly  1999 AIESAHYLGRNNHQMVMQHLRS-ALTPLVQKCQQMYIQCIHQKLYHLTQGDYEEFASIVVAARAA 2062
            .:|:   |.|.|...:..|||: |...|||:|||.|:|.||.:|.|||..||::|.:|:.:||.|
Zfish  1832 IMEA---LQRLNPAHIHAHLRTPAFHQLVQRCQQAYLQYIHHRLIHLTPADYDDFVNIIRSARGA 1893

  Fly  2063 FQITPEGNAQFKDWLQSIKRSKSCKKELWTQINAALQSNS 2102
            |.:||.|..||.|.||::||.|. .||||.:|:..:.:.|
Zfish  1894 FCLTPVGMMQFNDVLQNLKRGKQ-TKELWQRISLEMATFS 1932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34401	NP_001356949.1	None
zswim8	XP_005156782.1	SWIM	121..>253	CDD:302896	99/132 (75%)
zswim8	XP_005156782.1	Ins_allergen_rp	1828..>1925	CDD:284230	46/100 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596132
Domainoid	1	1.000	1069	1.000	Domainoid score	I22
eggNOG	1	0.900	-	-		E1_KOG3615
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1314	1.000	Inparanoid score	I147
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D54901at33208
OrthoFinder	1	1.000	-	-		FOG0006333
OrthoInspector	1	1.000	-	-		oto40486
orthoMCL	1	0.900	-	-		OOG6_107078
Panther	1	1.100	-	-	LDO	PTHR22619
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3876
SonicParanoid	1	1.000	-	-		X4608
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.880