DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr12 and KIRREL3

DIOPT Version :9

Sequence 1:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	225	Identity:	57/225 - (25%)
Similarity:	83/225 - (36%)	Gaps:	54/225 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GDSKLDNNLDSSDSPMF--EDSELMAHNTTVQLGGTAFLVCKVSGVDRVGVNWNQISWIRRRDWH 123
            |.:.|...:|....|..  |...|:     |.||..|...|..:|...:     .|.|::|
Human   327 GSTNLSRTVDVYFGPRMTTEPQSLL-----VDLGSDAIFSCAWTGNPSL-----TIVWMKR---- 377

  Fly   124 ILSSGAQLYTNDERFAILHTPGSNMWTLQIKFVQRRDHGMYECQVSTP-TGIISHFVNLQVVVPE 187
              .||..|              ||..||.:|.|::.|.|.|.|:...| .|.....|.|.|..|.
Human   378 --GSGVVL--------------SNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 426

  Fly   188 AFILGSGE----LHVDMGSTINLVCIIEKSPTPPQYVYWQKNDRLINYVDSRRDITIETTP---- 244
              |:.|.:    ||.:.|   .:.|.|..:| ||..:.|...:.::....|.| .|:||..
Human   427 --IISSTQTQHALHGEKG---QIKCFIRSTP-PPDRIAWSWKENVLESGTSGR-YTVETISTEEG 484

  Fly   245 --GPRTQSRLIIREPQVTDSGNYTCSASNT 272
              ...|.|.::..:.|..    |.|:|.|:
Human   485 VISTLTISNIVRADFQTI----YNCTAWNS 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr12	NP_652462.3	IG	86..183	CDD:214652	26/97 (27%)
		Ig_3	193..271	CDD:404760	21/87 (24%)
		Ig strand B	204..208	CDD:409353	0/3 (0%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	1/3 (33%)
		Ig strand F	264..269	CDD:409353	2/4 (50%)
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845
		IG_like	60..149	CDD:214653
		I-set	156..249	CDD:254352
		Ig2_KIRREL3-like	171..252	CDD:143236
		Ig_2	260..337	CDD:290606	2/9 (22%)
		I-set	341..422	CDD:254352	29/110 (26%)
		IGc2	355..406	CDD:197706	20/75 (27%)
		Ig5_KIRREL3	424..521	CDD:143306	24/98 (24%)
		IG_like	432..521	CDD:214653	21/88 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810