DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr12 and KIRREL2

DIOPT Version :9

Sequence 1:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	271	Identity:	65/271 - (23%)
Similarity:	93/271 - (34%)	Gaps:	75/271 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLRLRRPLHLMELRILLLCLPTLLLATTLEPDQKSILTDNDWKKLWMRGGINGDSKLDNNLDSSD 73
            :||:|.|    .|.:||.|                           .||            .:..
Human     1 MLRMRVP----ALLVLLFC---------------------------FRG------------RAGP 22

  Fly    74 SPMF----EDSELMAHNTTVQLGGTAFLVCKVSGVDRVGVNWNQISWIRRRDWHILSSGAQLYTN 134
            ||.|    ||       ..|.||..|.|.|      .:|..|..:.|.:..    |:.|.|   .
Human    23 SPHFLQQPED-------LVVLLGEEARLPC------ALGAYWGLVQWTKSG----LALGGQ---R 67

  Fly   135 D----ERFAILHTPGSNMWTLQIKFVQRRDHGMYECQVSTPTGIISHFVNLQVVV-PEA-FILGS 193
            |    .|:.|.....:....|.|:.|:..|...|||| :|..|:.|....|.|:| ||| .:||.
Human    68 DLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQ-ATQAGLRSRPAQLHVLVPPEAPQVLGG 131

  Fly   194 GELHVDMGSTINLVCIIEKSPTPPQYVYWQKNDRLINYVDSRRDITIETTPGPRTQSRLIIREPQ 258
            ..:.:..|...||.|.......|...:.|.::..|::.....:.:..|.||| ..:|.|.:....
Human   132 PSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPG-SVESTLTLTPFS 195

  Fly   259 VTDSGNYTCSA 269
            ..|...:.|.|
Human   196 HDDGATFVCRA 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr12	NP_652462.3	IG	86..183	CDD:214652	27/100 (27%)
		Ig_3	193..271	CDD:404760	16/77 (21%)
		Ig strand B	204..208	CDD:409353	2/3 (67%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	2/3 (67%)
		Ig strand F	264..269	CDD:409353	1/4 (25%)
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	29/109 (27%)
		IGc2	38..106	CDD:197706	21/81 (26%)
		I-set	126..224	CDD:254352	18/82 (22%)
		Ig2_KIRREL3-like	141..223	CDD:143236	15/67 (22%)
		Cell attachment site. /evidence=ECO:0000255	149..151		0/1 (0%)
		Ig	231..306	CDD:299845
		IG_like	234..308	CDD:214653
		Ig	312..395	CDD:299845
		I-set	317..395	CDD:254352
		Ig	397..501	CDD:299845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810