DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr12 and Kirrel3

DIOPT Version :9

Sequence 1:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus

Alignment Length:	225	Identity:	57/225 - (25%)
Similarity:	82/225 - (36%)	Gaps:	54/225 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GDSKLDNNLDSSDSPMF--EDSELMAHNTTVQLGGTAFLVCKVSGVDRVGVNWNQISWIRRRDWH 123
            |.:.|...:|....|..  |...|:     |.||..|...|...|...:     .|.|::|
Mouse   321 GSTNLSRTVDVYFGPRMTSEPQSLL-----VDLGSDAVFSCAWIGNPSL-----TIVWMKR---- 371

  Fly   124 ILSSGAQLYTNDERFAILHTPGSNMWTLQIKFVQRRDHGMYECQVSTP-TGIISHFVNLQVVVPE 187
              .||..|              ||..||.:|.|::.|.|.|.|:...| .|.....|.|.|..|.
Mouse   372 --GSGVVL--------------SNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 420

  Fly   188 AFILGSGE----LHVDMGSTINLVCIIEKSPTPPQYVYWQKNDRLINYVDSRRDITIETTP---- 244
              |:.|.:    ||.:.|   .:.|.|..:| ||..:.|...:.::....|.| .|:||..
Mouse   421 --IISSTQTQHALHGEKG---QIKCFIRSTP-PPDRIAWSWKENVLESGTSGR-YTVETVNTEEG 478

  Fly   245 --GPRTQSRLIIREPQVTDSGNYTCSASNT 272
              ...|.|.::..:.|..    |.|:|.|:
Mouse   479 VISTLTISNIVRADFQTI----YNCTAWNS 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr12	NP_652462.3	IG	86..183	CDD:214652	26/97 (27%)
		Ig_3	193..271	CDD:404760	21/87 (24%)
		Ig strand B	204..208	CDD:409353	0/3 (0%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	1/3 (33%)
		Ig strand F	264..269	CDD:409353	2/4 (50%)
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653
		Ig strand A'	56..60	CDD:409353
		Ig strand B	64..71	CDD:409353
		Ig strand C	78..82	CDD:409353
		Ig strand C'	84..87	CDD:409353
		Ig strand D	97..101	CDD:409353
		Ig strand E	104..116	CDD:409353
		Ig strand G	132..143	CDD:409353
		IgI_2_KIRREL3-like	149..246	CDD:409416
		Ig strand B	166..170	CDD:409416
		Ig strand C	180..184	CDD:409416
		Ig strand E	210..214	CDD:409416
		Ig strand F	224..229	CDD:409416
		Ig strand G	239..242	CDD:409416
		Ig	<267..334	CDD:416386	3/12 (25%)
		Ig strand B	267..274	CDD:409353
		Ig strand C	279..286	CDD:409353
		Ig strand C'	288..291	CDD:409353
		Ig strand D	298..302	CDD:409353
		Ig strand E	304..310	CDD:409353
		Ig strand G	321..334	CDD:409353	3/12 (25%)
		Ig	335..416	CDD:416386	29/110 (26%)
		Ig strand A'	343..347	CDD:409353	1/8 (13%)
		Ig strand B	350..360	CDD:409353	2/9 (22%)
		Ig strand C	365..371	CDD:409353	2/5 (40%)
		Ig strand E	381..387	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	418..515	CDD:409479	24/98 (24%)
		Ig strand B	436..440	CDD:409479	1/6 (17%)
		Ig strand C	450..454	CDD:409479	0/3 (0%)
		Ig strand E	481..485	CDD:409479	0/3 (0%)
		Ig strand F	496..501	CDD:409479	2/8 (25%)
		Ig strand G	509..512	CDD:409479
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810