DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr12 and robo4

DIOPT Version :9

Sequence 1:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	255	Identity:	51/255 - (20%)
Similarity:	88/255 - (34%)	Gaps:	62/255 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 EDSELMAHNTTVQLGGTAFLVCKVSGVDRVGVNWNQISWIRRRDWHILSSGAQLYTNDERFAILH 142
            ||..:...:..|.:|..|.:.|.    ..||.....::|  |:|..:::|..:.|| :.:..::.
Zfish   173 EDFRVQPSDVEVAIGEMATINCS----PPVGHPEPNVTW--RKDGILINSSNEHYT-ELKGKLII 230

  Fly   143 TPGSNMWTLQIKFVQRRDHGMYECQVSTPTGI-ISHFVNLQVVVPEAFILGSGELHVDMGSTINL 206
            .|           .|:.|.|:|.|..|...|: .|....|.|:.....:....::.|.:|.:...
Zfish   231 AP-----------AQKNDSGVYSCIASNMIGVRESRAARLSVLAKPVLLRKPEDVSVQLGESAQF 284

  Fly   207 VCIIEKSPTPPQYVYWQKNDRLINYVDSRRDITIETTPGPRTQSRLIIREPQ------VT--DSG 263
            .|..:..|.|.  :.|.:..                  ||....|.:|....      ||  |.|
Zfish   285 FCEADGDPMPS--IEWSREQ------------------GPLPNGRYLINPDHSLQIHYVTAQDMG 329

  Fly   264 NYTCSASN---TEPASIYVFVSKGDNMAAISRRKTSSADRLTHIFRSMLAPCLLLNTVVV 320
            .|:|:..|   ...||..:.|            :.:...||..:.:.:.|..:.|..|.|
Zfish   330 RYSCTVENKLGVSVASAQLLV------------EDAGGTRLRDLHKELSALRVSLENVTV 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr12	NP_652462.3	IG	86..183	CDD:214652	22/97 (23%)
		Ig_3	193..271	CDD:404760	16/85 (19%)
		Ig strand B	204..208	CDD:409353	0/3 (0%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	1/3 (33%)
		Ig strand F	264..269	CDD:409353	2/4 (50%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317
		I-set	71..168	CDD:254352
		I-set	175..261	CDD:254352	22/103 (21%)
		Ig2_Robo	177..261	CDD:143201	22/101 (22%)
		I-set	265..350	CDD:254352	19/104 (18%)
		Ig	282..350	CDD:299845	17/87 (20%)
		FN3	373..448	CDD:214495	2/5 (40%)
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900