DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr12 and lrit3a

DIOPT Version :9

Sequence 1:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001122166.1	Gene:	lrit3a / 558559	ZFINID:	ZDB-GENE-080723-63	Length:	636	Species:	Danio rerio

Alignment Length:	279	Identity:	52/279 - (18%)
Similarity:	88/279 - (31%)	Gaps:	88/279 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 QKSI--LTDNDWK---------KLWMRGGI-----------NGDSKLDNNLDSSDSPMFEDSEL- 82
            ||::  |.||.|.         :|....||           :|...|...|       |:.:||
Zfish   190 QKTVLGLQDNPWYCDCRISKLIELSKMAGIPVVLMDQVLTCSGPEHLSGVL-------FQRAELD 247

  Fly    83 ---------MAHNTTVQLGGTAFLVCKVSGVDRVGVNWNQISWIRRRDWHILSSGAQLYTNDERF 138
                     .|...|..||....|.|..:|.....:.|.             ::...:..|.
Zfish   248 QCVKPTVMTSATKITSPLGSNVLLRCDANGFPTPTLLWT-------------TADGSVVNNT--- 296

  Fly   139 AILHTPGSNM-WT-LQIKFVQRRDHGMYECQVSTPTGIISHFVNLQVVVPEAFILGSGELHVDMG 201
            .:..:||..: |: |.:..:..:|.|.|.|:...                   :.|:.|.::
Zfish   297 VVQESPGEGVRWSILSLHSIVFKDAGDYRCKAKN-------------------VAGNAEAYI--- 339

  Fly   202 STINLVCIIEKSPTPPQYVYWQKNDR--------LINYVDSRRDITIETTPGPRTQSRLIIREPQ 258
             |:::..:...:|.||..:..|..|:        .:....|...|||.|.|...|...|..|:..
Zfish   340 -TLSVDGVQPTTPFPPINITKQPEDQPTTTFTPTKMPLFTSLSPITITTRPVMTTMPPLTTRKSP 403

  Fly   259 VTDSGNYTCSASNTEPASI 277
            :...|......:..:||.:
Zfish   404 IPGGGVQRSPPAGDKPAKV 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr12	NP_652462.3	IG	86..183	CDD:214652	16/98 (16%)
		Ig_3	193..271	CDD:404760	17/85 (20%)
		Ig strand B	204..208	CDD:409353	0/3 (0%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	1/3 (33%)
		Ig strand F	264..269	CDD:409353	0/4 (0%)
lrit3a	NP_001122166.1	LRR_8	81..141	CDD:290566
		leucine-rich repeat	83..106	CDD:275378
		LRR_4	107..145	CDD:289563
		leucine-rich repeat	107..130	CDD:275378
		LRR_8	129..>171	CDD:290566
		LRR_4	129..170	CDD:289563
		leucine-rich repeat	131..154	CDD:275378
		leucine-rich repeat	155..168	CDD:275378
		TPKR_C2	199..249	CDD:301599	11/56 (20%)
		Ig	252..343	CDD:299845	20/129 (16%)
		IG_like	261..343	CDD:214653	19/120 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900