DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr12 and NCAM1

DIOPT Version :9

Sequence 1:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	298	Identity:	59/298 - (19%)
Similarity:	112/298 - (37%)	Gaps:	72/298 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LEPDQKSILTDNDWKKLWMRG---GINGDSKLDNNLDSSDSPMFEDSELMAH------------N 86
            |:.|.:.|:..|::  |.:||   ...|..:.:..:.:.....|:|.:::.:            |
Human   160 LKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVN 222

  Fly    87 TTVQLGGTAFLVCKVSGVDRVGVNWNQISWIRRRDWHILSSGAQLYTNDERFAILHTPGSNMWTL 151
            .|..||.:..|||...|.....::|.:             .|.|:...::....:.:..|:.  |
Human   223 ATANLGQSVTLVCDAEGFPEPTMSWTK-------------DGEQIEQEEDDEKYIFSDDSSQ--L 272

  Fly   152 QIKFVQRRDHGMYECQVSTPTGIISHFVNLQVVVPEAFILGSGELHVDMGSTINLVCIIEKSPTP 216
            .||.|.:.|...|.|......|.....::|:|...........:..:::...:.|.|  |.|..|
Human   273 TIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTC--EASGDP 335

  Fly   217 PQYVYWQKNDRLINYVD-------SRRDI----------------------TIETTPG---PRTQ 249
            ...:.|:.:.|.|:..:       .::::                      :.||..|   .|:.
Human   336 IPSITWRTSTRNISSEEKASWTRPEKQEVHAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSH 400

  Fly   250 SR---LIIREPQVTDSGNYTCSASNT---EPASIYVFV 281
            :|   |.::..|.||:|.|.|:||||   :..|:|:.|
Human   401 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr12	NP_652462.3	IG	86..183	CDD:214652	21/96 (22%)
		Ig_3	193..271	CDD:404760	21/112 (19%)
		Ig strand B	204..208	CDD:409353	1/3 (33%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	2/6 (33%)
		Ig strand F	264..269	CDD:409353	2/4 (50%)
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	8/31 (26%)
		Ig	211..307	CDD:325142	22/110 (20%)
		Ig	306..438	CDD:325142	26/133 (20%)
		Ig_3	447..519	CDD:316449
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810