DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr12 and itgb4

DIOPT Version :9

Sequence 1:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	276	Identity:	52/276 - (18%)
Similarity:	96/276 - (34%)	Gaps:	91/276 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 KLDNNLDSSDSPMFEDSELMAHNTTVQLGGTAFLVCKVSGVDRVGVNWNQISWIRRRD------- 121
            ||.:|:.|....:  ..|.::.|.....||       ...:.:..|..:||.|  |:|
Zfish   206 KLTSNITSFRQKL--QKERISGNLDAPEGG-------FDAILQTAVCQDQIGW--RKDSTHLLVF 259

  Fly   122 -----WHILSSGAQ-----LYTNDERFAILHTPGSNMWTLQIKFVQRRDHGMYECQVSTPT---- 172
                 :|..:.||.     |..|||:   .|......:|..:    |:|:      .|.||
Zfish   260 STESAFHYEADGANVLAGILDRNDEQ---CHLNVDGNYTHDV----RQDY------PSIPTLVRL 311

  Fly   173 ----------GIISHFVNLQVVVPEAF-ILGSGELHVDMGSTINLVCIIEKSPTPPQYVYWQKND 226
                      .:.:|..:....:.|.| |...|:|..|   :.|::.|:||:
Zfish   312 LVKHNIIPIFAVTNHSYSYYEKLHEYFPIAELGQLQED---SSNILSILEKA------------- 360

  Fly   227 RLINYVDSRRDITIETTPGPR-TQSRLIIREPQVTDSGNYTCSASNTEPASIYVFVSKGDNMAAI 290
                :.:.|..|:|.....|: .::::..:....::.||:..:...|....:        .|.|:
Zfish   361 ----FENIRSKISIRAEDRPKAVETKIFSQSGTFSEYGNFKITPGQTGKFKV--------RMKAL 413

  Fly   291 SR------RKTSSADR 300
            ::      .|.:.|||
Zfish   414 NQVGEEPVCKVNQADR 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr12	NP_652462.3	IG	86..183	CDD:214652	24/127 (19%)
		Ig_3	193..271	CDD:404760	13/78 (17%)
		Ig strand B	204..208	CDD:409353	1/3 (33%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	0/3 (0%)
		Ig strand F	264..269	CDD:409353	1/4 (25%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776	52/276 (19%)
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344
		FN3	1242..1326	CDD:238020
		FN3	1331..1420	CDD:238020
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900