DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr12 and SDK1

DIOPT Version :9

Sequence 1:NP_652462.3 Gene:dpr12 / 50320 FlyBaseID:FBgn0085414 Length:326 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:277 Identity:70/277 - (25%)
Similarity:106/277 - (38%) Gaps:73/277 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 WMRGGINGDSKLDN--------------NLDSSDSPMF------EDSELMAH------------- 85
            |.:..|: .|:|.|              .|...||.:|      |..|:..|             
Human   420 WYKDAIS-ISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFT 483

  Fly    86 ----NTTVQLGGTAFLVCKVSGVDRVGVNWNQISWIRRRDWHILSSGAQLYTNDERFAILHTPGS 146
                :|||..|.||.|.|:|||..:..:.|       :|:.|||:||:   ....||.:|.:.| 
Human   484 QRPVDTTVTDGMTAILRCEVSGAPKPAITW-------KRENHILASGS---VRIPRFMLLESGG- 537

  Fly   147 NMWTLQIKFVQRRDHGMYECQVSTPTGIISHFVNLQVVVPEAFILGSGELHVDM-GSTINLVCII 210
                |||..|..:|.|.|.|..:...|.::....| .|.....|:...|.||.: |:|..|.|..
Human   538 ----LQIAPVFIQDAGNYTCYAANTEGSLNASATL-TVWNRTSIVHPPEDHVVIKGTTATLHCGA 597

  Fly   211 EKSPTPPQYVYWQKNDRLINYVDSRRDITIETTPGPRTQSRLIIREPQVTDSGNYTCSASNTEPA 275
            ...|.......|:|::..:....:.| |.:|      ....|:|.:....|.|:|:|.       
Human   598 THDPRVSLRYVWKKDNVALTPSSTSR-IVVE------KDGSLLISQTWSGDIGDYSCE------- 648

  Fly   276 SIYVFVSKGDNMAAISR 292
                .||:|.|.:.::|
Human   649 ----IVSEGGNDSRMAR 661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr12NP_652462.3 IG 86..183 CDD:214652 32/96 (33%)
Ig_3 193..271 CDD:404760 19/78 (24%)
Ig strand B 204..208 CDD:409353 1/3 (33%)
Ig strand C 219..223 CDD:409353 0/3 (0%)
Ig strand E 250..254 CDD:409353 1/3 (33%)
Ig strand F 264..269 CDD:409353 2/4 (50%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352
Ig 122..176 CDD:143165
Ig 219..265 CDD:299845
IGc2 312..364 CDD:197706
I-set 386..475 CDD:254352 12/55 (22%)
Ig 404..472 CDD:143165 12/52 (23%)
I-set 480..570 CDD:254352 32/105 (30%)
Ig 494..570 CDD:299845 29/91 (32%)
I-set 575..664 CDD:254352 25/105 (24%)
Ig 580..664 CDD:299845 24/100 (24%)
FN3 668..759 CDD:238020
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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