DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr12 and igcm-2

DIOPT Version :9

Sequence 1:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	66/354 - (18%)
Similarity:	112/354 - (31%)	Gaps:	122/354 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PTLLLATTLEPDQKSILTDNDWKKLWMRGGINGDSKLDNNLDSSDSPMFEDS---ELMAHNTTVQ 90
            |.|.|:...|.|          |.|:....:|    ::.|..||....|..:   :|:..|.||.
Worm   170 PVLTLSNLEEGD----------KGLYTCLAVN----IEGNSTSSIDVRFTKATILDLIPLNKTVI 220

  Fly    91 LGGTAFLVCKVSG-VDRVGVNW----------------------NQISWIRRRD--WHILSSGAQ 130
            .|...|..|..:. ...:..:|                      ..:..:|:.|  |:...:...
Worm   221 EGSNVFWHCHANAQATAISYSWLFEKKPIKTTSLGLRSNIRSGDLSLQDVRKSDSGWYTCEAKNS 285

  Fly   131 LYTNDERFAILH---------------------------------TPGSNMWT------------ 150
            ........|.||                                 ||.|..|:
Worm   286 AGETTSSTAYLHVFYPPEPLSSHQPVQTVASGRNTTVSCDVIANPTPTSYTWSKNGHYLPTQASS 350

  Fly   151 -LQIKFVQRRDHGMYECQVSTPTG----IISHFVNLQVVVPEAF-ILGSGELHVDMGSTINLVCI 209
             :.|.:.:..|.|:|.||.....|    :.:|.:   |..|..| :....|:.|.:|..:::.|.
Worm   351 HIIISYAKPGDGGIYGCQADNIAGKGSIVETHLI---VAEPPVFTVAPPSEIKVRLGDQVSIPCQ 412

  Fly   210 IEKSPTPPQYVYWQKNDRLINYVDSRRDITIETTPGPRTQSRLIIREPQVTDSGNYTCSASNT-E 273
            ....|.|  .|||.::.:.||                  ||.|..::.:..|.|.|.|..:|: |
Worm   413 GFGDPMP--IVYWIRDKKRIN------------------QSTLTFKKVEHLDHGAYECVVANSVE 457

  Fly   274 PASIYVFVSKGDNMAAISRRKTSSADRLT 302
            ..|..|.:     :..|::.:.:|:.:.|
Worm   458 TISTRVML-----LVEITKPQMASSIKFT 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr12	NP_652462.3	IG	86..183	CDD:214652	25/171 (15%)
		Ig_3	193..271	CDD:404760	18/77 (23%)
		Ig strand B	204..208	CDD:409353	0/3 (0%)
		Ig strand C	219..223	CDD:409353	2/3 (67%)
		Ig strand E	250..254	CDD:409353	2/3 (67%)
		Ig strand F	264..269	CDD:409353	2/4 (50%)
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653
		Ig	124..200	CDD:386229	10/43 (23%)
		IG_like	214..298	CDD:214653	12/83 (14%)
		Ig_3	309..371	CDD:372822	10/61 (16%)
		Ig	389..467	CDD:386229	23/102 (23%)
		FN3	476..548	CDD:238020	2/6 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900